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- W1970436017 abstract "Antipsychotic drugs are believed to block central dopamine (DA) receptors, resulting in an accelerated turnover of DA and an accumulation of its metabolite homovanillic acid (HVA) in the brain. The time course for HVA, however, might not be the same with different drugs (Fregnan and Porta 1981; Chang et al. 1987a) and in different brain regions (Matsumoto et al. 1983; Chang et al. 1987b) and may also vary with different doses of a particular drug (Ahtee 1975; Chang et al. 1987b). As the question of the maximal effective timing of antipsychotics is of some importance in the design and interpretation of laboratory experiments, as well as clinical investigations, we undertook an evaluation of time-response curve of HVA in rat prefrontal cortex and striatum after single injections of haloperidol (HAL) of differing doses. The two brain regions investigated are believed to be implicated both in the antipsychotic action (Bannon and Roth 1983) and the extrapyramidal side effects (Snyder et al. 1974) of antipsychotics. Drug concentrations in plasma and" @default.
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- W1970436017 date "1988-10-01" @default.
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- W1970436017 title "Time course of homovanillic acid in brain regions and drug levels in plasma and striatum in haloperidol-treated rats" @default.
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- W1970436017 doi "https://doi.org/10.1016/0006-3223(88)90146-1" @default.
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