Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970443752> ?p ?o ?g. }
- W1970443752 endingPage "e45473" @default.
- W1970443752 startingPage "e45473" @default.
- W1970443752 abstract "Mephedrone (4-methylmethcathinone, MMC) is a popular recreational drug, yet its potential harms are yet to be fully established. The current study examined the impact of single or repeated MMC exposure on various neurochemical and behavioral measures in rats. In Experiment 1 male adolescent Wistar rats received single or repeated (once a day for 10 days) injections of MMC (30 mg/kg) or the comparator drug methamphetamine (METH, 2.5 mg/kg). Both MMC and METH caused robust hyperactivity in the 1 h following injection although this effect did not tend to sensitize with repeated treatment. Striatal dopamine (DA) levels were increased 1 h following either METH or MMC while striatal and hippocampal serotonin (5-HT) levels were decreased 1 h following MMC but not METH. MMC caused greater increases in 5-HT metabolism and greater reductions in DA metabolism in rats that had been previously exposed to MMC. Autoradiographic analysis showed no signs of neuroinflammation ([125I]CLINDE ligand used as a marker for translocator protein (TSPO) expression) with repeated exposure to either MMC or METH. In Experiment 2, rats received repeated MMC (7.5, 15 or 30 mg/kg once a day for 10 days) and were examined for residual behavioral effects following treatment. Repeated high (30 mg/kg) dose MMC produced impaired novel object recognition 5 weeks after drug treatment. However, no residual changes in 5-HT or DA tissue levels were observed at 7 weeks post-treatment. Overall these results show that MMC causes acute but not lasting changes in DA and 5-HT tissue concentrations. MMC can also cause long-term memory impairment. Future studies of cognitive function in MMC users are clearly warranted." @default.
- W1970443752 created "2016-06-24" @default.
- W1970443752 creator A5002397528 @default.
- W1970443752 creator A5002546901 @default.
- W1970443752 creator A5003886260 @default.
- W1970443752 creator A5005961234 @default.
- W1970443752 creator A5011474946 @default.
- W1970443752 creator A5022589029 @default.
- W1970443752 creator A5039494044 @default.
- W1970443752 creator A5049658239 @default.
- W1970443752 creator A5059030677 @default.
- W1970443752 creator A5067738102 @default.
- W1970443752 creator A5078685999 @default.
- W1970443752 date "2012-09-18" @default.
- W1970443752 modified "2023-10-17" @default.
- W1970443752 title "Mephedrone in Adolescent Rats: Residual Memory Impairment and Acute but Not Lasting 5-HT Depletion" @default.
- W1970443752 cites W1514803957 @default.
- W1970443752 cites W1546242462 @default.
- W1970443752 cites W1590614604 @default.
- W1970443752 cites W1960526592 @default.
- W1970443752 cites W1966417379 @default.
- W1970443752 cites W1967663026 @default.
- W1970443752 cites W1970073509 @default.
- W1970443752 cites W1972256875 @default.
- W1970443752 cites W1977213360 @default.
- W1970443752 cites W1979653155 @default.
- W1970443752 cites W1980354712 @default.
- W1970443752 cites W1982104252 @default.
- W1970443752 cites W1987657728 @default.
- W1970443752 cites W1989123841 @default.
- W1970443752 cites W1992139505 @default.
- W1970443752 cites W1995734607 @default.
- W1970443752 cites W2000071819 @default.
- W1970443752 cites W2000930207 @default.
- W1970443752 cites W2003168266 @default.
- W1970443752 cites W2009263798 @default.
- W1970443752 cites W2013984714 @default.
- W1970443752 cites W2025655040 @default.
- W1970443752 cites W2025657027 @default.
- W1970443752 cites W2028937126 @default.
- W1970443752 cites W2032144209 @default.
- W1970443752 cites W2034876350 @default.
- W1970443752 cites W2037164190 @default.
- W1970443752 cites W2058459083 @default.
- W1970443752 cites W2059224991 @default.
- W1970443752 cites W2063459474 @default.
- W1970443752 cites W2064425482 @default.
- W1970443752 cites W2064576666 @default.
- W1970443752 cites W2066750823 @default.
- W1970443752 cites W2081762124 @default.
- W1970443752 cites W2089043951 @default.
- W1970443752 cites W2089629661 @default.
- W1970443752 cites W2093419170 @default.
- W1970443752 cites W2097196401 @default.
- W1970443752 cites W2097791185 @default.
- W1970443752 cites W2102271024 @default.
- W1970443752 cites W2111038577 @default.
- W1970443752 cites W2121028217 @default.
- W1970443752 cites W2121303049 @default.
- W1970443752 cites W2124623204 @default.
- W1970443752 cites W2132011757 @default.
- W1970443752 cites W2133396498 @default.
- W1970443752 cites W2138516303 @default.
- W1970443752 cites W2140901931 @default.
- W1970443752 cites W2141638015 @default.
- W1970443752 cites W2145452630 @default.
- W1970443752 cites W2145815037 @default.
- W1970443752 cites W2146464634 @default.
- W1970443752 cites W2148240173 @default.
- W1970443752 cites W2148959594 @default.
- W1970443752 cites W2154041798 @default.
- W1970443752 cites W2163582349 @default.
- W1970443752 cites W2165489174 @default.
- W1970443752 cites W2620283078 @default.
- W1970443752 cites W296951674 @default.
- W1970443752 doi "https://doi.org/10.1371/journal.pone.0045473" @default.
- W1970443752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3445542" @default.
- W1970443752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23029034" @default.
- W1970443752 hasPublicationYear "2012" @default.
- W1970443752 type Work @default.
- W1970443752 sameAs 1970443752 @default.
- W1970443752 citedByCount "57" @default.
- W1970443752 countsByYear W19704437522013 @default.
- W1970443752 countsByYear W19704437522014 @default.
- W1970443752 countsByYear W19704437522015 @default.
- W1970443752 countsByYear W19704437522016 @default.
- W1970443752 countsByYear W19704437522017 @default.
- W1970443752 countsByYear W19704437522018 @default.
- W1970443752 countsByYear W19704437522020 @default.
- W1970443752 countsByYear W19704437522021 @default.
- W1970443752 countsByYear W19704437522022 @default.
- W1970443752 countsByYear W19704437522023 @default.
- W1970443752 crossrefType "journal-article" @default.
- W1970443752 hasAuthorship W1970443752A5002397528 @default.
- W1970443752 hasAuthorship W1970443752A5002546901 @default.
- W1970443752 hasAuthorship W1970443752A5003886260 @default.
- W1970443752 hasAuthorship W1970443752A5005961234 @default.
- W1970443752 hasAuthorship W1970443752A5011474946 @default.