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• W1970450187 abstract "Immunological tolerance to self requires naturally occurring regulatory T (T reg ) cells. Yet how they stably control autoimmune T cells remains obscure. Here, we show that T reg cells can render self-reactive human CD8 + T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen restimulation) in vitro, likely by controlling the costimulatory function of antigen-presenting cells. Anergic T cells were naïve in phenotype, lower than activated T cells in T cell receptor affinity for cognate antigen, and expressed several coinhibitory molecules, including cytotoxic T lymphocyte–associated antigen-4 (CTLA-4). Using these criteria, we detected in healthy individuals anergic T cells reactive with a skin antigen targeted in the autoimmune disease vitiligo. Collectively, our results suggest that T reg cell–mediated induction of anergy in autoimmune T cells is important for maintaining self-tolerance." @default.
• W1970450187 created "2016-06-24" @default.
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• W1970450187 date "2014-12-19" @default.
• W1970450187 modified "2023-10-02" @default.
• W1970450187 title "Detection of self-reactive CD8 ⁺ T cells with an anergic phenotype in healthy individuals" @default.
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• W1970450187 doi "https://doi.org/10.1126/science.aaa1292" @default.
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