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- W1970458021 startingPage "639" @default.
- W1970458021 abstract "Only a vanishingly small proportion of the almost infinite number of possible proteins occur in nature. Can this remaining potential of structural and functional diversity be used in the construction of new proteins? Is a “second evolution” of proteins and enzymes about to occur? These questions have suddenly become of interest because the recombinant DNA technique allows the synthesis of any given amino acid sequence. Examples of enzyme models demonstrate clearly that the unusual catalytic properties of enzymes are associated with the presence of a specifically folded polypeptide chain which has a complex three-dimensional form. The critical hurdle in the path of artificial proteins is thus the design of amino acid sequences which are able to fold into tertiary structures. — Recent studies on the topology and the mechanism of folding have provided considerable insight into the occurrence of, and the rules governing the three-dimensional architecture of proteins. Secondary structures apparently play a key role in the folding process; helices and “β-structures” act as nucleation centers directing folding and account for the surprisingly small number of different folding topologies. The problem of secondary structure formation can be investigated directly by means of conformational studies on model peptides. Oligopeptides with tailormade physicochemical, structural and conformational properties can already be designed. The theoretical and experimental basis for the construction of polypeptides with stable tertiary structures is therefore established. The path to macromolecules with an immense variety of novel properties lays before us." @default.
- W1970458021 created "2016-06-24" @default.
- W1970458021 creator A5055638727 @default.
- W1970458021 date "1985-08-01" @default.
- W1970458021 modified "2023-10-11" @default.
- W1970458021 title "The Construction of New Proteins and Enzymes-a Prospect for the Future?" @default.
- W1970458021 cites W1199184825 @default.
- W1970458021 cites W1446088809 @default.
- W1970458021 cites W1498620356 @default.
- W1970458021 cites W1534406401 @default.
- W1970458021 cites W1543736827 @default.
- W1970458021 cites W1561964169 @default.
- W1970458021 cites W1569553189 @default.
- W1970458021 cites W184469317 @default.
- W1970458021 cites W1875979868 @default.
- W1970458021 cites W1928915926 @default.
- W1970458021 cites W1948535084 @default.
- W1970458021 cites W1950684004 @default.
- W1970458021 cites W1965838279 @default.
- W1970458021 cites W1967488767 @default.
- W1970458021 cites W1968005823 @default.
- W1970458021 cites W1969339600 @default.
- W1970458021 cites W1971682433 @default.
- W1970458021 cites W1971896762 @default.
- W1970458021 cites W1972600295 @default.
- W1970458021 cites W1973665827 @default.
- W1970458021 cites W1974656966 @default.
- W1970458021 cites W1974866277 @default.
- W1970458021 cites W1975232154 @default.
- W1970458021 cites W1976020987 @default.
- W1970458021 cites W1976251704 @default.
- W1970458021 cites W1978578758 @default.
- W1970458021 cites W1979958617 @default.
- W1970458021 cites W1984640820 @default.
- W1970458021 cites W1984965754 @default.
- W1970458021 cites W1987511720 @default.
- W1970458021 cites W1989447327 @default.
- W1970458021 cites W1990473684 @default.
- W1970458021 cites W1991498388 @default.
- W1970458021 cites W1993187009 @default.
- W1970458021 cites W1993606408 @default.
- W1970458021 cites W1995907370 @default.
- W1970458021 cites W1996124986 @default.
- W1970458021 cites W1998280616 @default.
- W1970458021 cites W1998312296 @default.
- W1970458021 cites W1998870263 @default.
- W1970458021 cites W2001496277 @default.
- W1970458021 cites W2004297557 @default.
- W1970458021 cites W2004431978 @default.
- W1970458021 cites W2007370878 @default.
- W1970458021 cites W2008546617 @default.
- W1970458021 cites W2009588994 @default.
- W1970458021 cites W2011945107 @default.
- W1970458021 cites W2012716149 @default.
- W1970458021 cites W2014361380 @default.
- W1970458021 cites W2016012892 @default.
- W1970458021 cites W2020604206 @default.
- W1970458021 cites W2022173106 @default.
- W1970458021 cites W2022988139 @default.
- W1970458021 cites W2023140456 @default.
- W1970458021 cites W2025408524 @default.
- W1970458021 cites W2026046929 @default.
- W1970458021 cites W2026863841 @default.
- W1970458021 cites W2028376876 @default.
- W1970458021 cites W2030661117 @default.
- W1970458021 cites W2034583677 @default.
- W1970458021 cites W2035400404 @default.
- W1970458021 cites W2037717555 @default.
- W1970458021 cites W2038917819 @default.
- W1970458021 cites W2041678107 @default.
- W1970458021 cites W2044621526 @default.
- W1970458021 cites W2045395659 @default.
- W1970458021 cites W2050687084 @default.
- W1970458021 cites W2052469750 @default.
- W1970458021 cites W2053067247 @default.
- W1970458021 cites W2054711795 @default.
- W1970458021 cites W2054808476 @default.
- W1970458021 cites W2055101373 @default.
- W1970458021 cites W2056502094 @default.
- W1970458021 cites W2056958748 @default.
- W1970458021 cites W2058225478 @default.
- W1970458021 cites W2058645098 @default.
- W1970458021 cites W2059255310 @default.
- W1970458021 cites W2061308633 @default.
- W1970458021 cites W2064236716 @default.
- W1970458021 cites W2064286576 @default.
- W1970458021 cites W2064729553 @default.
- W1970458021 cites W2065242379 @default.
- W1970458021 cites W2065710574 @default.
- W1970458021 cites W2066657705 @default.
- W1970458021 cites W2069446215 @default.
- W1970458021 cites W2071575443 @default.
- W1970458021 cites W207568409 @default.
- W1970458021 cites W2077517054 @default.
- W1970458021 cites W2078968619 @default.
- W1970458021 cites W2079249590 @default.
- W1970458021 cites W2082143573 @default.
- W1970458021 cites W2083885829 @default.