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• W1970461463 startingPage "331" @default.
• W1970461463 abstract "The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SJL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host immune system is required for tumor growth. The phenomenon of reverse immune surveillance related to B cell lymphomas has recently also been characterized in another inbred mouse strain, C57L/J. Moreover, elements of reverse immune surveillance have been observed in several other mouse strains that develop B cell lymphomas, suggesting that this lymphomagenic mechanism may be more common than first envisioned. In SJL and C57L mice, the B lymphoma cells express an MMTV-encoded superantigen (vSAg29) that stimulates syngeneic CD4+T cells bearing V β 16 in their TCR. In contrast to the mRNAs for other MMTVs in normal mouse B cells, vSAg29 mRNA initiates in the env(META) region, undergoes splicing in the 3′env region, and continues through the 3′LTR. Copious cytokine production, including IFN- γ, IL-4 and IL-5 accompanies the response of the T cells to this vSAg. In addition to cytokines produced by vSAg-responsive T cells, more recent evidence indicates that another cytokine, LT αβ 2, which is expressed on the lymphoma cell surface, also plays a role in the promotion of the B cell lymphoma growth. It is possible that interaction with LT β -R on follicular dendritic cells or other stromal elements facilitates tumor growth by preventing apoptosis of the malignant B cells. To what degree these findings in the mouse are relevant to the development and/or growth of human B lymphoma cells remains to be determined. However, endogenous retroviral sequences do exist in the human genome. Interestingly, some of these sequences are homologous to MMTV, and are transcribed in B lymphoblastoid cells. Moreover, microorganisms that are infectious for human B cells, such as EBV and Herpes Virus 8, may also produce superantigens." @default.
• W1970461463 created "2016-06-24" @default.
• W1970461463 creator A5017916363 @default.
• W1970461463 creator A5085722992 @default.
• W1970461463 date "2000-10-01" @default.
• W1970461463 modified "2023-10-18" @default.
• W1970461463 title "Requirement for reverse immune surveillance for the growth of germinal center-derived murine lymphomas" @default.
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• W1970461463 doi "https://doi.org/10.1006/scbi.2000.0330" @default.
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