Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970486640> ?p ?o ?g. }
- W1970486640 endingPage "328" @default.
- W1970486640 startingPage "319" @default.
- W1970486640 abstract "Human albumin is extensively used and investigated in clinical fluid management. Whether albumin confers sufficient benefit to justify its cost has been a subject of enduring controversy. A 2003 systematic review assembled evidence of benefit, but uncertainty has persisted. Abundant additional data have been newly reported, and this review provides an update. Major recent developments include the largest ever single randomized trial in the field of fluid management as well as the largest ever meta-analysis of randomized trials in the field. The randomized trial confirmed the safety of albumin in intensive care unit patients, while the meta-analysis demonstrated that albumin administration reduces morbidity in broad populations of acutely ill hospitalized patients. In liver disease, new randomized trials have shown that albumin can reduce morbidity as an adjunct to paracentesis and improve circulatory function in spontaneous bacterial peritonitis. Large observational studies have provided evidence of a survival advantage among cardiac surgery patients receiving albumin rather than artificial colloids. For extracorporeal circuit priming during cardiopulmonary bypass, albumin was found in a meta-analysis to maintain platelet counts and fluid balance more effectively than crystalloid. Randomized trials in both cardiac and noncardiac surgery indicated less impairment of coagulation by albumin than hydroxyethyl starch. Improved oxygenation, augmented loss of excess fluid and reduced morbidity after albumin supplementation were demonstrated in a randomized trial of hypoalbuminemic patients. A large-scale pharmacovigilance study showed serious adverse events in albumin recipients to be rare. Emerging evidence has further supported many of the current uses of albumin in fluid management. Keywords: Serum albumin, fluid therapy, treatment outcome, critical illness, liver diseases, surgery, hypoalbuminemia, safety" @default.
- W1970486640 created "2016-06-24" @default.
- W1970486640 creator A5056872170 @default.
- W1970486640 date "2006-09-01" @default.
- W1970486640 modified "2023-10-18" @default.
- W1970486640 title "Colloidal and Pharmacological Activity of Albumin in Clinical Fluid Management:Recent Developments" @default.
- W1970486640 cites W126204014 @default.
- W1970486640 cites W1583940462 @default.
- W1970486640 cites W1607369519 @default.
- W1970486640 cites W1963638955 @default.
- W1970486640 cites W1964338316 @default.
- W1970486640 cites W1968108840 @default.
- W1970486640 cites W1973050622 @default.
- W1970486640 cites W1981442890 @default.
- W1970486640 cites W1983945906 @default.
- W1970486640 cites W1984802658 @default.
- W1970486640 cites W1986289947 @default.
- W1970486640 cites W1988557863 @default.
- W1970486640 cites W1992934121 @default.
- W1970486640 cites W1996688094 @default.
- W1970486640 cites W2001578366 @default.
- W1970486640 cites W2002300878 @default.
- W1970486640 cites W2003707006 @default.
- W1970486640 cites W2005198956 @default.
- W1970486640 cites W200562694 @default.
- W1970486640 cites W2007496527 @default.
- W1970486640 cites W2008344139 @default.
- W1970486640 cites W2009070322 @default.
- W1970486640 cites W2012170541 @default.
- W1970486640 cites W2012594970 @default.
- W1970486640 cites W2016889358 @default.
- W1970486640 cites W2017973849 @default.
- W1970486640 cites W2018586741 @default.
- W1970486640 cites W2020368637 @default.
- W1970486640 cites W2020655787 @default.
- W1970486640 cites W2023909702 @default.
- W1970486640 cites W2023914296 @default.
- W1970486640 cites W2024682912 @default.
- W1970486640 cites W2027157695 @default.
- W1970486640 cites W2027166083 @default.
- W1970486640 cites W2027457014 @default.
- W1970486640 cites W2029672419 @default.
- W1970486640 cites W2035140417 @default.
- W1970486640 cites W2036290945 @default.
- W1970486640 cites W2037301086 @default.
- W1970486640 cites W2037511867 @default.
- W1970486640 cites W2041983220 @default.
- W1970486640 cites W2048245345 @default.
- W1970486640 cites W2052689998 @default.
- W1970486640 cites W2053554506 @default.
- W1970486640 cites W2053769824 @default.
- W1970486640 cites W2055236705 @default.
- W1970486640 cites W2056677038 @default.
- W1970486640 cites W2057780772 @default.
- W1970486640 cites W2057881500 @default.
- W1970486640 cites W2058842482 @default.
- W1970486640 cites W2059103024 @default.
- W1970486640 cites W2060559966 @default.
- W1970486640 cites W2064914299 @default.
- W1970486640 cites W2067953378 @default.
- W1970486640 cites W2069642844 @default.
- W1970486640 cites W2072835185 @default.
- W1970486640 cites W2073024831 @default.
- W1970486640 cites W2073117981 @default.
- W1970486640 cites W2075238334 @default.
- W1970486640 cites W2079870004 @default.
- W1970486640 cites W2080619455 @default.
- W1970486640 cites W2080942352 @default.
- W1970486640 cites W2081317807 @default.
- W1970486640 cites W2084206146 @default.
- W1970486640 cites W2087507473 @default.
- W1970486640 cites W2092918979 @default.
- W1970486640 cites W2097071107 @default.
- W1970486640 cites W2098131461 @default.
- W1970486640 cites W209992625 @default.
- W1970486640 cites W2101553638 @default.
- W1970486640 cites W2102177338 @default.
- W1970486640 cites W2105350302 @default.
- W1970486640 cites W2129198157 @default.
- W1970486640 cites W2134481878 @default.
- W1970486640 cites W2137973795 @default.
- W1970486640 cites W2142844479 @default.
- W1970486640 cites W2143239617 @default.
- W1970486640 cites W2143432233 @default.
- W1970486640 cites W2148096965 @default.
- W1970486640 cites W2154866406 @default.
- W1970486640 cites W2158214252 @default.
- W1970486640 cites W2159426640 @default.
- W1970486640 cites W2169281816 @default.
- W1970486640 cites W2172166586 @default.
- W1970486640 cites W2175631128 @default.
- W1970486640 cites W2197525896 @default.
- W1970486640 cites W2242185212 @default.
- W1970486640 cites W2265768762 @default.
- W1970486640 cites W2322673970 @default.
- W1970486640 cites W2328379097 @default.
- W1970486640 cites W2396268423 @default.
- W1970486640 cites W2396535312 @default.