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• W1970489172 abstract "Sulfur dioxide (SO2) has been associated with excessive mortality during air pollution disasters such as that which occurred in Meuse Valley, Belgium in 1930, DonoraPennsylvania, in 1948 and London in 1952. The SO2 particulate complex results chiefly fromthe burning of fossil fuels. Exposure can cause irritant and toxic effects on the humanairways and result in broncho- constriction. It also can aggravate existing pulmonary orcardiac problems. A positive interaction between particles and SO2 to produce morphologicchanges in airways has been suggested by smog incidents, but has not been evaluated byexperiments. So, this study was done to answer the following questions: (1) Whatmorphologic changes are produced by repeated injury to airway epithelial cells by SO2? (2)What is the time course of these morphologic features? (3) Can a model of acute bronchitisbe created which is not due to infection? Ultrastructural changes occurring in the epithelialcells lining the airways of the experimental rats were studied. A sequence of epithelialchanges was seen with exposure to 100, 200 or 400 p.p.m. for up to 4 weeks. For example:loss of cilia, vacuolation, pyknosis, goblet cell hyperplasia and the development of stratifiedsquamous epithelium after 2 to 7 days at 200 p.p.m Higher doses (400 p.p.m.) producedsquamous cell metaplasia after 2 weeks. Exposure to 40 p.p.m. SO2 alone for 4 hours per day for 6 weeks produced no changes, but 24 hours after a 4 hours exposure to 40 p.p.m. SO2 plus 0.74 gm of carbon dust per cu.m. of air, neutrophils were recruited into airwayepithelium. It is suggested that this synergistic effect is due to the carbon particles adsorbing SO2, which leaches off slowly, perhaps within macrophages, to recruit Leucocytes in airways. African Journal of Health Sciences Vol. 14 (3-4) 2007: pp. 129-136" @default.
• W1970489172 created "2016-06-24" @default.
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• W1970489172 date "2008-06-20" @default.
• W1970489172 modified "2023-09-26" @default.
• W1970489172 title "Ultrastructural study of the effect of air pollution by SO2 on the respiratory air-ways" @default.
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• W1970489172 doi "https://doi.org/10.4314/ajhs.v14i3.30859" @default.
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