FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970490705> ?p ?o ?g. }

• W1970490705 endingPage "39" @default.
• W1970490705 startingPage "31" @default.
• W1970490705 abstract "Background. Extracorporeal photochemotherapy (ECP) produces clinical improvements in refractory/resistant graft-versus-host disease (GvHD). Immunological mechanisms of ECP are still under investigation. Methods. We have evaluated the changes in frequency and immunophenotype of circulating regulatory T cells (T-regs) in 10 patients undergoing allogeneic hematopoietic stem cell transplantation, receiving ECP for acute (n=4) or chronic (n=6) GvHD. T-regs were monitored for expression of surface CD4, CD25, GITR, CD45RO, CD62L and intracytoplasmic Foxp3. T-regs were sorted by fluorescence-activated cell sorting to perform functional assays by interferon (IFN)-γ enzyme-linked immunospot and real-time quantitative polymerase chain reaction (RQ-PCR) to measure Foxp3, transforming growth factor (TGF)-β, and interleukin (IL)-10 mRNA. Results. ECP was accompanied by a significant increase of CD4+CD25+ T-regs after six procedures, increasing from 8.9% to 29.1% of total CD4 (P<0.05), with a simultaneous increase of glucocorticoid induced tumor necrosis factor receptor expression on CD4+CD25+ cells (from 15% to 40.8%, P<0.05). This increase was sustained after 12 procedures. T-regs expressed high levels of CD62L, CD45RO, and Foxp3. Sorted CD4+CD25+ T-regs were potently inhibitory toward the CD4+CD25− fraction, when matched with an allogeneic target (IFN-γ secretion was reduced by 79%). Trans-well experiments showed that cell-to-cell contact was necessary to exert inhibitory activity. RQ-PCR revealed a significant expression of Foxp3 in CD4+CD25+ T-regs, but there was virtually no detection of TGF-β and IL-10. GvHD improved in all patients, allowing tapering or discontinuation of immunosuppressive drugs. Conclusion. Our study shows a time correlation between ECP and increasing percentages of circulating functional T-regs. Albeit suggestive, our results need to be confirmed on larger series to determine the actual role of T-reg in mediating the clinical effect of ECP." @default.
• W1970490705 created "2016-06-24" @default.
• W1970490705 creator A5002730356 @default.
• W1970490705 creator A5009985541 @default.
• W1970490705 creator A5051520180 @default.
• W1970490705 creator A5056136982 @default.
• W1970490705 creator A5056726791 @default.
• W1970490705 creator A5066180999 @default.
• W1970490705 creator A5072815973 @default.
• W1970490705 creator A5077958266 @default.
• W1970490705 creator A5078748313 @default.
• W1970490705 creator A5078858949 @default.
• W1970490705 creator A5083769556 @default.
• W1970490705 date "2007-07-15" @default.
• W1970490705 modified "2023-10-16" @default.
• W1970490705 title "Extracorporeal Photochemotherapy Is Accompanied by Increasing Levels of Circulating CD4+CD25+GITR+Foxp3+CD62L+ Functional Regulatory T-Cells in Patients With Graft-Versus-Host Disease" @default.
• W1970490705 cites W1675113161 @default.
• W1970490705 cites W1894088929 @default.
• W1970490705 cites W1980211566 @default.
• W1970490705 cites W1985138302 @default.
• W1970490705 cites W1993310853 @default.
• W1970490705 cites W1996385095 @default.
• W1970490705 cites W2011814690 @default.
• W1970490705 cites W2019060341 @default.
• W1970490705 cites W2036424821 @default.
• W1970490705 cites W2050482887 @default.
• W1970490705 cites W2058113413 @default.
• W1970490705 cites W2059340815 @default.
• W1970490705 cites W2061462324 @default.
• W1970490705 cites W2066885693 @default.
• W1970490705 cites W2081240360 @default.
• W1970490705 cites W2088127225 @default.
• W1970490705 cites W2088422105 @default.
• W1970490705 cites W2100088787 @default.
• W1970490705 cites W2100357356 @default.
• W1970490705 cites W2102474483 @default.
• W1970490705 cites W2107277218 @default.
• W1970490705 cites W2109346271 @default.
• W1970490705 cites W2116493118 @default.
• W1970490705 cites W2122445377 @default.
• W1970490705 cites W2132289468 @default.
• W1970490705 cites W2134648443 @default.
• W1970490705 cites W2141324982 @default.
• W1970490705 cites W2149123553 @default.
• W1970490705 cites W2149617440 @default.
• W1970490705 cites W2158092720 @default.
• W1970490705 cites W2160666689 @default.
• W1970490705 cites W2161000130 @default.
• W1970490705 cites W2168740346 @default.
• W1970490705 doi "https://doi.org/10.1097/01.tp.0000267785.52567.9c" @default.
• W1970490705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17627234" @default.
• W1970490705 hasPublicationYear "2007" @default.
• W1970490705 type Work @default.
• W1970490705 sameAs 1970490705 @default.
• W1970490705 citedByCount "136" @default.
• W1970490705 countsByYear W19704907052012 @default.
• W1970490705 countsByYear W19704907052013 @default.
• W1970490705 countsByYear W19704907052014 @default.
• W1970490705 countsByYear W19704907052015 @default.
• W1970490705 countsByYear W19704907052016 @default.
• W1970490705 countsByYear W19704907052017 @default.
• W1970490705 countsByYear W19704907052018 @default.
• W1970490705 countsByYear W19704907052019 @default.
• W1970490705 countsByYear W19704907052020 @default.
• W1970490705 countsByYear W19704907052021 @default.
• W1970490705 countsByYear W19704907052022 @default.
• W1970490705 countsByYear W19704907052023 @default.
• W1970490705 crossrefType "journal-article" @default.
• W1970490705 hasAuthorship W1970490705A5002730356 @default.
• W1970490705 hasAuthorship W1970490705A5009985541 @default.
• W1970490705 hasAuthorship W1970490705A5051520180 @default.
• W1970490705 hasAuthorship W1970490705A5056136982 @default.
• W1970490705 hasAuthorship W1970490705A5056726791 @default.
• W1970490705 hasAuthorship W1970490705A5066180999 @default.
• W1970490705 hasAuthorship W1970490705A5072815973 @default.
• W1970490705 hasAuthorship W1970490705A5077958266 @default.
• W1970490705 hasAuthorship W1970490705A5078748313 @default.
• W1970490705 hasAuthorship W1970490705A5078858949 @default.
• W1970490705 hasAuthorship W1970490705A5083769556 @default.
• W1970490705 hasBestOaLocation W19704907051 @default.
• W1970490705 hasConcept C126322002 @default.
• W1970490705 hasConcept C203014093 @default.
• W1970490705 hasConcept C2776090121 @default.
• W1970490705 hasConcept C2778296632 @default.
• W1970490705 hasConcept C2779727006 @default.
• W1970490705 hasConcept C2911091166 @default.
• W1970490705 hasConcept C553184892 @default.
• W1970490705 hasConcept C71924100 @default.
• W1970490705 hasConcept C79484868 @default.
• W1970490705 hasConcept C86803240 @default.
• W1970490705 hasConcept C8891405 @default.
• W1970490705 hasConceptScore W1970490705C126322002 @default.
• W1970490705 hasConceptScore W1970490705C203014093 @default.
• W1970490705 hasConceptScore W1970490705C2776090121 @default.
• W1970490705 hasConceptScore W1970490705C2778296632 @default.
• W1970490705 hasConceptScore W1970490705C2779727006 @default.
• W1970490705 hasConceptScore W1970490705C2911091166 @default.
• W1970490705 hasConceptScore W1970490705C553184892 @default.

• next