Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970510308> ?p ?o ?g. }
- W1970510308 endingPage "22" @default.
- W1970510308 startingPage "1" @default.
- W1970510308 abstract "In patients with multiple sclerosis (MS), pain is a frequent and disabling symptom. The prevalence is in the range 29–86 % depending upon the assessment protocols utilised and the definition of pain applied. Neuropathic pain that develops secondary to demyelination, neuroinflammation and axonal damage in the central nervous system is the most distressing and difficult type of pain to treat. Although dysaesthetic extremity pain, L’hermitte’s sign and trigeminal neuralgia are the most common neuropathic pain conditions reported by patients with MS, research directed at gaining insight into the complex mechanisms underpinning the pathobiology of MS-associated neuropathic pain is in its relative infancy. By contrast, there is a wealth of knowledge on the neurobiology of neuropathic pain induced by peripheral nerve injury. To date, the majority of research in the MS field has used rodent models of experimental autoimmune encephalomyelitis (EAE) as these models have many clinical and neuropathological features in common with those observed in patients with MS. However, it is only relatively recently that EAE-rodents have been utilised to investigate the mechanisms contributing to the development and maintenance of MS-associated central neuropathic pain. Importantly, EAE-rodent models exhibit pro-nociceptive behaviours predominantly in the lower extremities (tail and hindlimbs) as seen clinically in patients with MS-neuropathic pain. Herein, we review research to date on the pathophysiological mechanisms underpinning MS-associated neuropathic pain as well as the pharmacological management of this condition. We also identify knowledge gaps to guide future research in this important field." @default.
- W1970510308 created "2016-06-24" @default.
- W1970510308 creator A5036818230 @default.
- W1970510308 creator A5045802348 @default.
- W1970510308 date "2013-11-14" @default.
- W1970510308 modified "2023-10-11" @default.
- W1970510308 title "Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models" @default.
- W1970510308 cites W1499075438 @default.
- W1970510308 cites W1506772383 @default.
- W1970510308 cites W1543274849 @default.
- W1970510308 cites W1550823327 @default.
- W1970510308 cites W1607206274 @default.
- W1970510308 cites W1654451162 @default.
- W1970510308 cites W1705148237 @default.
- W1970510308 cites W1894946695 @default.
- W1970510308 cites W1937650001 @default.
- W1970510308 cites W1967331290 @default.
- W1970510308 cites W1967499842 @default.
- W1970510308 cites W1969693550 @default.
- W1970510308 cites W1971378633 @default.
- W1970510308 cites W1973290618 @default.
- W1970510308 cites W1975326687 @default.
- W1970510308 cites W1975875514 @default.
- W1970510308 cites W1977536374 @default.
- W1970510308 cites W1979001185 @default.
- W1970510308 cites W1980555335 @default.
- W1970510308 cites W1980778842 @default.
- W1970510308 cites W1981608333 @default.
- W1970510308 cites W1985664605 @default.
- W1970510308 cites W1985989596 @default.
- W1970510308 cites W1986913568 @default.
- W1970510308 cites W1987588078 @default.
- W1970510308 cites W1987613482 @default.
- W1970510308 cites W1990119512 @default.
- W1970510308 cites W1990810755 @default.
- W1970510308 cites W1993662841 @default.
- W1970510308 cites W1993804929 @default.
- W1970510308 cites W1995747351 @default.
- W1970510308 cites W1996712837 @default.
- W1970510308 cites W1997598438 @default.
- W1970510308 cites W1998132604 @default.
- W1970510308 cites W1998138279 @default.
- W1970510308 cites W1999768705 @default.
- W1970510308 cites W2000770184 @default.
- W1970510308 cites W2001257231 @default.
- W1970510308 cites W2004552736 @default.
- W1970510308 cites W2006190434 @default.
- W1970510308 cites W2008356917 @default.
- W1970510308 cites W2011425358 @default.
- W1970510308 cites W2011960880 @default.
- W1970510308 cites W2012241026 @default.
- W1970510308 cites W2012682323 @default.
- W1970510308 cites W2012860078 @default.
- W1970510308 cites W2013725496 @default.
- W1970510308 cites W2015637511 @default.
- W1970510308 cites W2016007532 @default.
- W1970510308 cites W2019388237 @default.
- W1970510308 cites W2019641262 @default.
- W1970510308 cites W2020241617 @default.
- W1970510308 cites W2020279774 @default.
- W1970510308 cites W2021219363 @default.
- W1970510308 cites W2021568221 @default.
- W1970510308 cites W2023174313 @default.
- W1970510308 cites W2023188936 @default.
- W1970510308 cites W2023414643 @default.
- W1970510308 cites W2024581949 @default.
- W1970510308 cites W2028061046 @default.
- W1970510308 cites W2028499628 @default.
- W1970510308 cites W2029613509 @default.
- W1970510308 cites W2031159576 @default.
- W1970510308 cites W2032358175 @default.
- W1970510308 cites W2034659335 @default.
- W1970510308 cites W2035146882 @default.
- W1970510308 cites W2038332622 @default.
- W1970510308 cites W2040632916 @default.
- W1970510308 cites W2041222336 @default.
- W1970510308 cites W2041554374 @default.
- W1970510308 cites W2042329538 @default.
- W1970510308 cites W2045024696 @default.
- W1970510308 cites W2045027053 @default.
- W1970510308 cites W2045281561 @default.
- W1970510308 cites W2045406685 @default.
- W1970510308 cites W2045802866 @default.
- W1970510308 cites W2052654921 @default.
- W1970510308 cites W2055553707 @default.
- W1970510308 cites W2056247628 @default.
- W1970510308 cites W2060798259 @default.
- W1970510308 cites W2060900087 @default.
- W1970510308 cites W2061051739 @default.
- W1970510308 cites W2061378788 @default.
- W1970510308 cites W2063201358 @default.
- W1970510308 cites W2063244411 @default.
- W1970510308 cites W2065754612 @default.
- W1970510308 cites W2066791546 @default.
- W1970510308 cites W2067212451 @default.
- W1970510308 cites W2067523098 @default.
- W1970510308 cites W2068620691 @default.
- W1970510308 cites W2069606030 @default.