Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970510706> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1970510706 endingPage "405" @default.
- W1970510706 startingPage "391" @default.
- W1970510706 abstract "Skeletal muscle is a target tissue of choice for the gene therapy of both muscle and non-muscle disorders. Investigations of gene transfer into muscle have progressed considerably from the expression of plasmid reporter genes to the production of therapeutic proteins such as trophic factors, hormones, antigens, ion channels or cytoskeletal proteins. Viral vectors are intrinsically the most efficient vehicles to deliver genes into skeletal muscles. But, because viruses are associated with a variety of problems (such as immune and inflammatory responses, toxicity, limited large scale production yields, limitations in the size of the carried therapeutic genes), nonviral vectors remain a viable alternative. In addition, as nonviral vectors allow to transfer genetic structures of various sizes (including large plasmid DNA carrying fulllength coding sequences of the gene of interest), they can be used in various gene therapy approaches. However, given the lack of efficiency of nonviral vectors in experimental studies and in the clinical settings, the overall outcome clearly indicates that improved synthetic vectors and/or delivery techniques are required for successful clinical gene therapy. Today, most of the potential muscle-targeted clinical applications seem geared toward peripheral ischemia (mainly through local injections) and cancer and infectious vaccines, and one locoregional administration of naked DNA in Duchenne muscular dystrophy. This review updates the developments in clinical applications of the various plasmid-based non-viral methods under investigation for the delivery of genes to muscles. Keywords: non-viral, gene therapy, skeletal muscle, cancer, cardiovascular diseases, neuromuscular diseases, human, clinical trials" @default.
- W1970510706 created "2016-06-24" @default.
- W1970510706 creator A5002346621 @default.
- W1970510706 date "2008-10-01" @default.
- W1970510706 modified "2023-09-23" @default.
- W1970510706 title "Muscular Gene Transfer Using Nonviral Vectors" @default.
- W1970510706 doi "https://doi.org/10.2174/156652308786070998" @default.
- W1970510706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18855634" @default.
- W1970510706 hasPublicationYear "2008" @default.
- W1970510706 type Work @default.
- W1970510706 sameAs 1970510706 @default.
- W1970510706 citedByCount "58" @default.
- W1970510706 countsByYear W19705107062012 @default.
- W1970510706 countsByYear W19705107062013 @default.
- W1970510706 countsByYear W19705107062014 @default.
- W1970510706 countsByYear W19705107062015 @default.
- W1970510706 countsByYear W19705107062017 @default.
- W1970510706 countsByYear W19705107062018 @default.
- W1970510706 countsByYear W19705107062019 @default.
- W1970510706 countsByYear W19705107062020 @default.
- W1970510706 countsByYear W19705107062022 @default.
- W1970510706 crossrefType "journal-article" @default.
- W1970510706 hasAuthorship W1970510706A5002346621 @default.
- W1970510706 hasConcept C104317684 @default.
- W1970510706 hasConcept C105702510 @default.
- W1970510706 hasConcept C111599444 @default.
- W1970510706 hasConcept C135983454 @default.
- W1970510706 hasConcept C22744801 @default.
- W1970510706 hasConcept C2778943923 @default.
- W1970510706 hasConcept C2779030066 @default.
- W1970510706 hasConcept C2779959927 @default.
- W1970510706 hasConcept C32470452 @default.
- W1970510706 hasConcept C40767141 @default.
- W1970510706 hasConcept C54355233 @default.
- W1970510706 hasConcept C60644358 @default.
- W1970510706 hasConcept C70721500 @default.
- W1970510706 hasConcept C86803240 @default.
- W1970510706 hasConcept C92087593 @default.
- W1970510706 hasConceptScore W1970510706C104317684 @default.
- W1970510706 hasConceptScore W1970510706C105702510 @default.
- W1970510706 hasConceptScore W1970510706C111599444 @default.
- W1970510706 hasConceptScore W1970510706C135983454 @default.
- W1970510706 hasConceptScore W1970510706C22744801 @default.
- W1970510706 hasConceptScore W1970510706C2778943923 @default.
- W1970510706 hasConceptScore W1970510706C2779030066 @default.
- W1970510706 hasConceptScore W1970510706C2779959927 @default.
- W1970510706 hasConceptScore W1970510706C32470452 @default.
- W1970510706 hasConceptScore W1970510706C40767141 @default.
- W1970510706 hasConceptScore W1970510706C54355233 @default.
- W1970510706 hasConceptScore W1970510706C60644358 @default.
- W1970510706 hasConceptScore W1970510706C70721500 @default.
- W1970510706 hasConceptScore W1970510706C86803240 @default.
- W1970510706 hasConceptScore W1970510706C92087593 @default.
- W1970510706 hasIssue "5" @default.
- W1970510706 hasLocation W19705107061 @default.
- W1970510706 hasLocation W19705107062 @default.
- W1970510706 hasOpenAccess W1970510706 @default.
- W1970510706 hasPrimaryLocation W19705107061 @default.
- W1970510706 hasRelatedWork W1602083480 @default.
- W1970510706 hasRelatedWork W1987229981 @default.
- W1970510706 hasRelatedWork W1987990767 @default.
- W1970510706 hasRelatedWork W2121693322 @default.
- W1970510706 hasRelatedWork W2358963224 @default.
- W1970510706 hasRelatedWork W2394205039 @default.
- W1970510706 hasRelatedWork W2605942115 @default.
- W1970510706 hasRelatedWork W37120060 @default.
- W1970510706 hasRelatedWork W4235931591 @default.
- W1970510706 hasRelatedWork W4239269329 @default.
- W1970510706 hasVolume "8" @default.
- W1970510706 isParatext "false" @default.
- W1970510706 isRetracted "false" @default.
- W1970510706 magId "1970510706" @default.
- W1970510706 workType "article" @default.