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- W1970526536 abstract "Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR) γ activation protects against tumourigenesis, results from a few clinical trials using PPAR γ ligands as monotherapy show modest success. In spite of this, several groups reported exciting results with therapeutic regimens that combine PPAR γ ligands with other compounds: chemotherapeutic agents, retinoid x receptor (RXR) α agonists, statins, or cell-to-cell signaling molecules in preclinical cancer models and human trials. Here we have compiled an extensive review, consolidating the existing literature, which overwhelmingly supports a beneficial effect of treating with PPAR γ ligands in combination with existing chemotherapies versus their monotherapy in cancer. There are many examples in which combination therapy resulted in synergistic/additive effects on apoptosis, differentiation, and the ability to reduce cell growth and tumour burden. There are also studies that indicate that PPAR γ ligand pretreatment overcomes resistance and reduces toxicities. Several mechanisms are explored to explain these protective effects. This paper highlights each of these studies that, collectively, make a very strong case for the use of PPAR γ ligands in combination with other agents in the treatment and management of several cancers." @default.
- W1970526536 created "2016-06-24" @default.
- W1970526536 creator A5062366621 @default.
- W1970526536 creator A5064600090 @default.
- W1970526536 date "2012-01-01" @default.
- W1970526536 modified "2023-09-27" @default.
- W1970526536 title "The Key to Unlocking the Chemotherapeutic Potential of PPAR<i>γ</i>Ligands: Having the Right Combination" @default.
- W1970526536 cites W1520292475 @default.
- W1970526536 cites W1532932203 @default.
- W1970526536 cites W1639924204 @default.
- W1970526536 cites W1778336443 @default.
- W1970526536 cites W1811602282 @default.
- W1970526536 cites W1927684145 @default.
- W1970526536 cites W1965436414 @default.
- W1970526536 cites W1966996834 @default.
- W1970526536 cites W1968980738 @default.
- W1970526536 cites W1969409726 @default.
- W1970526536 cites W1972499055 @default.
- W1970526536 cites W1975160900 @default.
- W1970526536 cites W1975777549 @default.
- W1970526536 cites W1976666735 @default.
- W1970526536 cites W1979761686 @default.
- W1970526536 cites W1979804924 @default.
- W1970526536 cites W1984328540 @default.
- W1970526536 cites W1988499671 @default.
- W1970526536 cites W1992610206 @default.
- W1970526536 cites W1993342645 @default.
- W1970526536 cites W1995925880 @default.
- W1970526536 cites W1997608954 @default.
- W1970526536 cites W1998258610 @default.
- W1970526536 cites W1998440406 @default.
- W1970526536 cites W1998997365 @default.
- W1970526536 cites W2001177059 @default.
- W1970526536 cites W2001676296 @default.
- W1970526536 cites W2005159659 @default.
- W1970526536 cites W2006658102 @default.
- W1970526536 cites W2013237043 @default.
- W1970526536 cites W2014271351 @default.
- W1970526536 cites W2020380655 @default.
- W1970526536 cites W2022282235 @default.
- W1970526536 cites W2030414680 @default.
- W1970526536 cites W2031694725 @default.
- W1970526536 cites W2032670726 @default.
- W1970526536 cites W2035539313 @default.
- W1970526536 cites W2040920295 @default.
- W1970526536 cites W2041993106 @default.
- W1970526536 cites W2042393893 @default.
- W1970526536 cites W2043971599 @default.
- W1970526536 cites W2046051952 @default.
- W1970526536 cites W2048115542 @default.
- W1970526536 cites W2050352100 @default.
- W1970526536 cites W2052052955 @default.
- W1970526536 cites W2055400687 @default.
- W1970526536 cites W2055561557 @default.
- W1970526536 cites W2056734036 @default.
- W1970526536 cites W2057123987 @default.
- W1970526536 cites W2059068055 @default.
- W1970526536 cites W2060932390 @default.
- W1970526536 cites W2072249486 @default.
- W1970526536 cites W2072380594 @default.
- W1970526536 cites W2092041087 @default.
- W1970526536 cites W2094382632 @default.
- W1970526536 cites W2096953444 @default.
- W1970526536 cites W2096959265 @default.
- W1970526536 cites W2098361864 @default.
- W1970526536 cites W2104787501 @default.
- W1970526536 cites W2105719905 @default.
- W1970526536 cites W2107229603 @default.
- W1970526536 cites W2107752044 @default.
- W1970526536 cites W2115837052 @default.
- W1970526536 cites W2116845296 @default.
- W1970526536 cites W2117692326 @default.
- W1970526536 cites W2119983127 @default.
- W1970526536 cites W2120913071 @default.
- W1970526536 cites W2123237110 @default.
- W1970526536 cites W2124100109 @default.
- W1970526536 cites W2124624490 @default.
- W1970526536 cites W2125686203 @default.
- W1970526536 cites W2126225553 @default.
- W1970526536 cites W2127287248 @default.
- W1970526536 cites W2128866959 @default.
- W1970526536 cites W2130177169 @default.
- W1970526536 cites W2131301324 @default.
- W1970526536 cites W2132478764 @default.
- W1970526536 cites W2132741387 @default.
- W1970526536 cites W2138994529 @default.
- W1970526536 cites W2142047562 @default.
- W1970526536 cites W2142850084 @default.
- W1970526536 cites W2146283444 @default.
- W1970526536 cites W2151807579 @default.
- W1970526536 cites W2159174329 @default.
- W1970526536 cites W2164193797 @default.
- W1970526536 cites W2164277862 @default.
- W1970526536 cites W2295706507 @default.
- W1970526536 cites W4211107646 @default.
- W1970526536 cites W4243180786 @default.
- W1970526536 cites W4247638161 @default.
- W1970526536 cites W4250210754 @default.