FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970528096> ?p ?o ?g. }

• W1970528096 endingPage "819" @default.
• W1970528096 startingPage "811" @default.
• W1970528096 abstract "The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature and amount of α-cyclodextrin ( α-CD), β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The interactions of drug-cyclodextrin in solution were investigated by the phase-solubility analysis. Diazepam (nitrazepam) content in aqueous complexation medium was analyzed UV spectrophotometrically. Classical solubility data were used to derive apparent stability constants (K1:1) which were used to derive thermodynamic parameters for the diazepam (nitrazepam)-cyclodextrin complexes. Since all phase solubility plots were of AL–types, and calculated Slopes after linear regression analysis were found to be less than 1, it could be assumed that stoichiometry of the formed binary systems was 1:1. According to the calculated K1:1 values, the stability of the complexes of diazepam and nitrazepam with a-CD, β-CD and 2-HP-β-CD varies as follows: 2-HP-β-CD > β-CD > β-CD. The a-CD has higher affinity for dissolving nitrazepam compared to diazepam. While all parameters lead to an improvement in solubility, the largest effect was obtained for guest-host complexation with 2-HP-β-CD. The solubility of diazepam and nitrazepam in water increased 93.02 times and 64.23 times, respectively, in the presence of 40% (w/w) 2-HP-β-CD, at 25°C. Solubility data for diazepam and nitrazepam in aqueous 2-HP-b-CD were used to derive thermodynamic parameters, ΔG° at 298 K = –14.43 kJ·mol–1, ΔH° = 0.79 kJ·mol–1, ΔS° at 298 K = 51.17 J·mol–1·K–1 and ΔG° at 298 K = –13.43 kJ·mol–1, ΔH° = 2.38 kJ·mol–1, ΔS° at 298 K = 53.01 J·mol–1·K–1, respectively. Formation of inclusion complexes substantially increases the water solubility of diazepam and nitrazepam. Diazepam and nitrazepam dissolution thermodynamics in aqueous 2-HP-β-CD were characterized by spontaneous and endothermic dissolution and hydrophobic interactions." @default.
• W1970528096 created "2016-06-24" @default.
• W1970528096 creator A5010486797 @default.
• W1970528096 creator A5012828288 @default.
• W1970528096 creator A5023166984 @default.
• W1970528096 creator A5046605119 @default.
• W1970528096 date "2012-01-01" @default.
• W1970528096 modified "2023-09-27" @default.
• W1970528096 title "Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam: Phase-Solubility Analysis, Thermodynamic Properties" @default.
• W1970528096 cites W197507320 @default.
• W1970528096 cites W1982770385 @default.
• W1970528096 cites W2023896967 @default.
• W1970528096 cites W2074582913 @default.
• W1970528096 cites W2090573640 @default.
• W1970528096 cites W2116251480 @default.
• W1970528096 cites W2119904380 @default.
• W1970528096 cites W2139291218 @default.
• W1970528096 cites W4206001762 @default.
• W1970528096 doi "https://doi.org/10.4236/ajac.2012.312107" @default.
• W1970528096 hasPublicationYear "2012" @default.
• W1970528096 type Work @default.
• W1970528096 sameAs 1970528096 @default.
• W1970528096 citedByCount "23" @default.
• W1970528096 countsByYear W19705280962014 @default.
• W1970528096 countsByYear W19705280962015 @default.
• W1970528096 countsByYear W19705280962016 @default.
• W1970528096 countsByYear W19705280962017 @default.
• W1970528096 countsByYear W19705280962018 @default.
• W1970528096 countsByYear W19705280962019 @default.
• W1970528096 countsByYear W19705280962020 @default.
• W1970528096 countsByYear W19705280962021 @default.
• W1970528096 countsByYear W19705280962022 @default.
• W1970528096 countsByYear W19705280962023 @default.
• W1970528096 crossrefType "journal-article" @default.
• W1970528096 hasAuthorship W1970528096A5010486797 @default.
• W1970528096 hasAuthorship W1970528096A5012828288 @default.
• W1970528096 hasAuthorship W1970528096A5023166984 @default.
• W1970528096 hasAuthorship W1970528096A5046605119 @default.
• W1970528096 hasBestOaLocation W19705280961 @default.
• W1970528096 hasConcept C155574463 @default.
• W1970528096 hasConcept C178790620 @default.
• W1970528096 hasConcept C184651966 @default.
• W1970528096 hasConcept C185592680 @default.
• W1970528096 hasConcept C2776175493 @default.
• W1970528096 hasConcept C2777207853 @default.
• W1970528096 hasConcept C2779433975 @default.
• W1970528096 hasConcept C43617362 @default.
• W1970528096 hasConcept C44280652 @default.
• W1970528096 hasConcept C71924100 @default.
• W1970528096 hasConcept C88380143 @default.
• W1970528096 hasConcept C98274493 @default.
• W1970528096 hasConceptScore W1970528096C155574463 @default.
• W1970528096 hasConceptScore W1970528096C178790620 @default.
• W1970528096 hasConceptScore W1970528096C184651966 @default.
• W1970528096 hasConceptScore W1970528096C185592680 @default.
• W1970528096 hasConceptScore W1970528096C2776175493 @default.
• W1970528096 hasConceptScore W1970528096C2777207853 @default.
• W1970528096 hasConceptScore W1970528096C2779433975 @default.
• W1970528096 hasConceptScore W1970528096C43617362 @default.
• W1970528096 hasConceptScore W1970528096C44280652 @default.
• W1970528096 hasConceptScore W1970528096C71924100 @default.
• W1970528096 hasConceptScore W1970528096C88380143 @default.
• W1970528096 hasConceptScore W1970528096C98274493 @default.
• W1970528096 hasIssue "12" @default.
• W1970528096 hasLocation W19705280961 @default.
• W1970528096 hasOpenAccess W1970528096 @default.
• W1970528096 hasPrimaryLocation W19705280961 @default.
• W1970528096 hasRelatedWork W1990847867 @default.
• W1970528096 hasRelatedWork W2034366881 @default.
• W1970528096 hasRelatedWork W2066133926 @default.
• W1970528096 hasRelatedWork W2275322305 @default.
• W1970528096 hasRelatedWork W2398714054 @default.
• W1970528096 hasRelatedWork W2437459011 @default.
• W1970528096 hasRelatedWork W3068579964 @default.
• W1970528096 hasRelatedWork W2183843638 @default.
• W1970528096 hasRelatedWork W2466544189 @default.
• W1970528096 hasRelatedWork W2588010632 @default.
• W1970528096 hasVolume "03" @default.
• W1970528096 isParatext "false" @default.
• W1970528096 isRetracted "false" @default.
• W1970528096 magId "1970528096" @default.
• W1970528096 workType "article" @default.