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- W1970538289 abstract "The family of peroxisome proliferator-activated receptors (PPARs) is the molecular target of synthetic antidiabetic and hypolipidemic drugs. The side effects of these drugs are limiting their use in patients with high lipid levels. Natural compounds, like Docosahexaenoic acid (DHA) from fish oil, have beneficial effects in the treatment of metabolic diseases, and several DHA derivatives are known to activate PPAR genes. Experimental studies on affinities of DHA and its derivatives for PPARs are not available. In the present study we are therefore using computational docking, molecular dynamics simulation, and several scoring programs to predict affinities and binding modes of DHA for PPARs and retinoid-X receptor α, which is the DNA binding partner of PPARs. The calculations indicated that DHA binds to PPARs and the retinoid-X receptor α with high affinity, and that different PPARs exhibited different structural effects on the first four carbons atoms of DHA. Our data indicate that the beneficial health effects of DHA may be obtained by high affinity binding to the PPARs." @default.
- W1970538289 created "2016-06-24" @default.
- W1970538289 creator A5020144569 @default.
- W1970538289 creator A5072644640 @default.
- W1970538289 date "2008-09-01" @default.
- W1970538289 modified "2023-10-11" @default.
- W1970538289 title "Molecular recognition of Docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor α" @default.
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- W1970538289 doi "https://doi.org/10.1016/j.jmgm.2008.04.008" @default.
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