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- W1970551487 abstract "Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFβ acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORγ-dependent Th17 cells. IL-23 – a member of the IL-12 family – activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 – another IL-12 family member – plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies." @default.
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- W1970551487 date "2008-12-01" @default.
- W1970551487 modified "2023-09-23" @default.
- W1970551487 title "Cytokines that regulate autoimmunity" @default.
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- W1970551487 doi "https://doi.org/10.1016/j.coi.2008.09.003" @default.
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