Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970565305> ?p ?o ?g. }
- W1970565305 endingPage "22" @default.
- W1970565305 startingPage "9" @default.
- W1970565305 abstract "The CD154/CD40 pathway is required for the development and progression of disease in a variety of autoimmune model systems. We have demonstrated previously that long-term anti-CD154 treatment of nephritic (SWRxNZB)F1 mice prolonged survival and preserved kidney function. Herein we ask if long-term treatment is required and further characterize the protective effect on renal pathology by examining alpha-smooth muscle actin, collagen and TGF-beta1 expression in renal tissue. The effects of anti-CD154 on brain and heart inflammation are also examined. Three dosing strategies of anti-CD154 mAb were compared in SNF1 mice that exhibited moderate or severe nephritis: (1) weekly for 6 weeks; (2) monthly; (3) weekly for 6-12 weeks followed by monthly dosing. Proteinuria, serum anti-DNA, anti-CD154 pharmacokinetics and serum soluble CD154 analyses were performed. Anti-CD154 treatment of moderate disease increased survival across all regimens, although weekly followed by monthly maintenance dosing proved most efficacious. This regime also inhibited renal alpha-smooth muscle actin and collagen deposition. Only the most aggressive anti-CD154 treatment protocol increased survival in severely nephritic mice. Long-term anti-CD154 treatment significantly inhibits key mediators of kidney fibrosis and is required to maximize survival and renal function. Potential reasons for differential therapeutic efficacy in moderately vs severely nephritic mice are discussed." @default.
- W1970565305 created "2016-06-24" @default.
- W1970565305 creator A5029086303 @default.
- W1970565305 creator A5066003007 @default.
- W1970565305 creator A5079610481 @default.
- W1970565305 date "2001-01-01" @default.
- W1970565305 modified "2023-09-27" @default.
- W1970565305 title "Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis" @default.
- W1970565305 cites W1963910613 @default.
- W1970565305 cites W1969979568 @default.
- W1970565305 cites W1971737777 @default.
- W1970565305 cites W1987968095 @default.
- W1970565305 cites W1993487971 @default.
- W1970565305 cites W1995188840 @default.
- W1970565305 cites W2005540893 @default.
- W1970565305 cites W2013346489 @default.
- W1970565305 cites W2016542967 @default.
- W1970565305 cites W2021421029 @default.
- W1970565305 cites W2022405886 @default.
- W1970565305 cites W2023997415 @default.
- W1970565305 cites W2031680198 @default.
- W1970565305 cites W2052034658 @default.
- W1970565305 cites W2052803753 @default.
- W1970565305 cites W2063661003 @default.
- W1970565305 cites W2068488477 @default.
- W1970565305 cites W2085406842 @default.
- W1970565305 cites W2086435048 @default.
- W1970565305 cites W2094270753 @default.
- W1970565305 cites W2096280264 @default.
- W1970565305 cites W2101492664 @default.
- W1970565305 cites W2103928142 @default.
- W1970565305 cites W2116911322 @default.
- W1970565305 cites W2127530565 @default.
- W1970565305 cites W2160119440 @default.
- W1970565305 cites W2160734066 @default.
- W1970565305 cites W271729629 @default.
- W1970565305 doi "https://doi.org/10.1191/096120301668384751" @default.
- W1970565305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11243513" @default.
- W1970565305 hasPublicationYear "2001" @default.
- W1970565305 type Work @default.
- W1970565305 sameAs 1970565305 @default.
- W1970565305 citedByCount "27" @default.
- W1970565305 countsByYear W19705653052013 @default.
- W1970565305 countsByYear W19705653052016 @default.
- W1970565305 countsByYear W19705653052021 @default.
- W1970565305 crossrefType "journal-article" @default.
- W1970565305 hasAuthorship W1970565305A5029086303 @default.
- W1970565305 hasAuthorship W1970565305A5066003007 @default.
- W1970565305 hasAuthorship W1970565305A5079610481 @default.
- W1970565305 hasConcept C126322002 @default.
- W1970565305 hasConcept C154317977 @default.
- W1970565305 hasConcept C159641895 @default.
- W1970565305 hasConcept C202751555 @default.
- W1970565305 hasConcept C203014093 @default.
- W1970565305 hasConcept C2776914184 @default.
- W1970565305 hasConcept C2777058396 @default.
- W1970565305 hasConcept C2777288759 @default.
- W1970565305 hasConcept C2778653478 @default.
- W1970565305 hasConcept C2779147130 @default.
- W1970565305 hasConcept C2779234475 @default.
- W1970565305 hasConcept C2779561371 @default.
- W1970565305 hasConcept C2780091579 @default.
- W1970565305 hasConcept C2780559512 @default.
- W1970565305 hasConcept C39347974 @default.
- W1970565305 hasConcept C55493867 @default.
- W1970565305 hasConcept C71924100 @default.
- W1970565305 hasConcept C86803240 @default.
- W1970565305 hasConcept C98274493 @default.
- W1970565305 hasConceptScore W1970565305C126322002 @default.
- W1970565305 hasConceptScore W1970565305C154317977 @default.
- W1970565305 hasConceptScore W1970565305C159641895 @default.
- W1970565305 hasConceptScore W1970565305C202751555 @default.
- W1970565305 hasConceptScore W1970565305C203014093 @default.
- W1970565305 hasConceptScore W1970565305C2776914184 @default.
- W1970565305 hasConceptScore W1970565305C2777058396 @default.
- W1970565305 hasConceptScore W1970565305C2777288759 @default.
- W1970565305 hasConceptScore W1970565305C2778653478 @default.
- W1970565305 hasConceptScore W1970565305C2779147130 @default.
- W1970565305 hasConceptScore W1970565305C2779234475 @default.
- W1970565305 hasConceptScore W1970565305C2779561371 @default.
- W1970565305 hasConceptScore W1970565305C2780091579 @default.
- W1970565305 hasConceptScore W1970565305C2780559512 @default.
- W1970565305 hasConceptScore W1970565305C39347974 @default.
- W1970565305 hasConceptScore W1970565305C55493867 @default.
- W1970565305 hasConceptScore W1970565305C71924100 @default.
- W1970565305 hasConceptScore W1970565305C86803240 @default.
- W1970565305 hasConceptScore W1970565305C98274493 @default.
- W1970565305 hasIssue "1" @default.
- W1970565305 hasLocation W19705653051 @default.
- W1970565305 hasLocation W19705653052 @default.
- W1970565305 hasOpenAccess W1970565305 @default.
- W1970565305 hasPrimaryLocation W19705653051 @default.
- W1970565305 hasRelatedWork W1989802976 @default.
- W1970565305 hasRelatedWork W2052161644 @default.
- W1970565305 hasRelatedWork W2055352031 @default.
- W1970565305 hasRelatedWork W2169540937 @default.
- W1970565305 hasRelatedWork W2238633398 @default.
- W1970565305 hasRelatedWork W2766832026 @default.