FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970565585> ?p ?o ?g. }

• W1970565585 endingPage "F1435" @default.
• W1970565585 startingPage "F1424" @default.
• W1970565585 abstract "Contraction of detrusor smooth muscle (DSM) at short muscle lengths generates a stiffness component we termed adjustable passive stiffness (APS) that is retained in tissues incubated in a Ca 2+ -free solution, shifts the DSM length-passive tension curve up and to the left, and is softened by muscle strain and release (strain softened). In the present study, we tested the hypothesis that APS is due to slowly cycling actomyosin cross bridges. APS and active tension produced by the stimulus, KCl, displayed similar length dependencies with identical optimum length values. The myosin II inhibitor blebbistatin relaxed active tension maintained during a KCl-induced contraction and the passive tension maintained during stress-relaxation induced by muscle stretch in a Ca 2+ -free solution. Passive tension was attributed to tension maintaining rather than tension developing cross bridges because tension did not recover after a rapid 10% stretch and release as it did during a KCl-induced contraction. APS generated by a KCl-induced contraction in intact tissues was preserved in tissues permeabilized with Triton X-100. Blebbistatin and the actin polymerization inhibitor latrunculin-B reduced the degree of APS generated by a KCl-induced contraction. The degree of APS generated by KCl was inhibited to a greater degree than was the peak KCl-induced tension by rhoA kinase and cyclooxygenase inhibitors. These data support the hypothesis that APS is due to slowly cycling actomyosin cross bridges and suggest that cross bridges may play a novel role in DSM that uniquely serves to ensure proper contractile function over an extreme working length range." @default.
• W1970565585 created "2016-06-24" @default.
• W1970565585 creator A5060700283 @default.
• W1970565585 creator A5087691612 @default.
• W1970565585 date "2010-06-01" @default.
• W1970565585 modified "2023-10-15" @default.
• W1970565585 title "Evidence that actomyosin cross bridges contribute to “passive” tension in detrusor smooth muscle" @default.
• W1970565585 cites W1584749760 @default.
• W1970565585 cites W179885216 @default.
• W1970565585 cites W1929482471 @default.
• W1970565585 cites W1965736605 @default.
• W1970565585 cites W1971990081 @default.
• W1970565585 cites W1977737067 @default.
• W1970565585 cites W1980056833 @default.
• W1970565585 cites W1981363543 @default.
• W1970565585 cites W1990433209 @default.
• W1970565585 cites W1990799497 @default.
• W1970565585 cites W1997087774 @default.
• W1970565585 cites W2005298247 @default.
• W1970565585 cites W2009582775 @default.
• W1970565585 cites W2017385989 @default.
• W1970565585 cites W2023410176 @default.
• W1970565585 cites W2028163040 @default.
• W1970565585 cites W2035995170 @default.
• W1970565585 cites W2041378783 @default.
• W1970565585 cites W2052978794 @default.
• W1970565585 cites W2058581358 @default.
• W1970565585 cites W2060499407 @default.
• W1970565585 cites W2071568346 @default.
• W1970565585 cites W2073895076 @default.
• W1970565585 cites W2078026023 @default.
• W1970565585 cites W2080758057 @default.
• W1970565585 cites W2083728577 @default.
• W1970565585 cites W2086445776 @default.
• W1970565585 cites W2089837717 @default.
• W1970565585 cites W2091685087 @default.
• W1970565585 cites W2098909725 @default.
• W1970565585 cites W2112397651 @default.
• W1970565585 cites W2113588020 @default.
• W1970565585 cites W2117863128 @default.
• W1970565585 cites W2121052425 @default.
• W1970565585 cites W2122053013 @default.
• W1970565585 cites W2123737741 @default.
• W1970565585 cites W2129032866 @default.
• W1970565585 cites W2136289712 @default.
• W1970565585 cites W2141972769 @default.
• W1970565585 cites W2145121491 @default.
• W1970565585 cites W2161924618 @default.
• W1970565585 cites W2163513026 @default.
• W1970565585 cites W2169400659 @default.
• W1970565585 cites W2169854777 @default.
• W1970565585 cites W2173089663 @default.
• W1970565585 cites W2186370106 @default.
• W1970565585 cites W2243195272 @default.
• W1970565585 cites W2259754948 @default.
• W1970565585 cites W2289095747 @default.
• W1970565585 cites W2314005127 @default.
• W1970565585 cites W4246118847 @default.
• W1970565585 doi "https://doi.org/10.1152/ajprenal.00635.2009" @default.
• W1970565585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2886818" @default.
• W1970565585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20375119" @default.
• W1970565585 hasPublicationYear "2010" @default.
• W1970565585 type Work @default.
• W1970565585 sameAs 1970565585 @default.
• W1970565585 citedByCount "28" @default.
• W1970565585 countsByYear W19705655852012 @default.
• W1970565585 countsByYear W19705655852013 @default.
• W1970565585 countsByYear W19705655852014 @default.
• W1970565585 countsByYear W19705655852015 @default.
• W1970565585 countsByYear W19705655852016 @default.
• W1970565585 countsByYear W19705655852017 @default.
• W1970565585 countsByYear W19705655852019 @default.
• W1970565585 countsByYear W19705655852021 @default.
• W1970565585 countsByYear W19705655852022 @default.
• W1970565585 crossrefType "journal-article" @default.
• W1970565585 hasAuthorship W1970565585A5060700283 @default.
• W1970565585 hasAuthorship W1970565585A5087691612 @default.
• W1970565585 hasBestOaLocation W19705655852 @default.
• W1970565585 hasConcept C105702510 @default.
• W1970565585 hasConcept C112950240 @default.
• W1970565585 hasConcept C12554922 @default.
• W1970565585 hasConcept C125705527 @default.
• W1970565585 hasConcept C134018914 @default.
• W1970565585 hasConcept C159985019 @default.
• W1970565585 hasConcept C163415756 @default.
• W1970565585 hasConcept C185592680 @default.
• W1970565585 hasConcept C186068551 @default.
• W1970565585 hasConcept C192562407 @default.
• W1970565585 hasConcept C207200792 @default.
• W1970565585 hasConcept C2776050358 @default.
• W1970565585 hasConcept C2776329151 @default.
• W1970565585 hasConcept C2777093181 @default.
• W1970565585 hasConcept C3018112276 @default.
• W1970565585 hasConcept C55493867 @default.
• W1970565585 hasConcept C62478195 @default.
• W1970565585 hasConcept C68731436 @default.
• W1970565585 hasConcept C6997183 @default.
• W1970565585 hasConcept C71924100 @default.

• next