FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970577029> ?p ?o ?g. }

• W1970577029 endingPage "805" @default.
• W1970577029 startingPage "800" @default.
• W1970577029 abstract "Osteopenia due to deficient extracellular matrix synthesis is a hallmark of osteogenesis imperfecta (OI). Previous studies carried out within 72 h of osteoblast subculture, at an early stage of matrix synthesis, indicated that for osteoblasts derived from human OI patients the total amounts of collagen, osteonectin, and three proteoglycans were significantly reduced, while total amounts of thrombospondin, fibronectin, and matrix hyaluronan were elevated compared with age-matched controls. The current study was undertaken to follow OI osteoblast matrix metabolism as that matrix is synthesized, deposited, and matured. Steady-state metabolic radiolabeling was used to follow the metabolism of collagen, hyaluronan, and total proteoglycan by OI and normal osteoblasts for up to 5 weeks. Trabecular osteoblasts from non-OI controls showed an increase in total and matrix-associated collagen synthesis during the first and second week, reaching steady-state levels by week 4. In contrast, cultured OI osteoblasts did not increase either the total (medium + matrix-associated) or matrix-associated collagen during the entire 5-week period. Proteoglycan synthesis exhibited a pattern similar to that for collagen. OI-derived proteoglycans differed from controls in that levels in OI cultures did not reflect the normal time-dependent increase in total proteoglycan and proteoglycan matrix deposition. OI osteoblast hyaluronan synthesis was increased when compared with age-matched controls during 4 weeks of culture. In contrast, the ratios of calcium to phosphorus solublized from control and the OI extracellular matrix were not statistically different. Thus, with respect to the synthesis of collagen, proteoglycans, and hyaluronan, OI osteoblasts fail to parallel controls in depositing and elaborating extracellular matrix during 35 days in culture." @default.
• W1970577029 created "2016-06-24" @default.
• W1970577029 creator A5055180025 @default.
• W1970577029 creator A5082022638 @default.
• W1970577029 creator A5083825372 @default.
• W1970577029 date "2009-12-03" @default.
• W1970577029 modified "2023-10-10" @default.
• W1970577029 title "Long-term extracellular matrix metabolism by cultured human osteogenesis imperfecta osteoblasts" @default.
• W1970577029 cites W1570147293 @default.
• W1970577029 cites W1576215194 @default.
• W1970577029 cites W1971366877 @default.
• W1970577029 cites W1976515381 @default.
• W1970577029 cites W1982212249 @default.
• W1970577029 cites W1987191843 @default.
• W1970577029 cites W1987424147 @default.
• W1970577029 cites W1999853133 @default.
• W1970577029 cites W2013239288 @default.
• W1970577029 cites W2031768903 @default.
• W1970577029 cites W2036867570 @default.
• W1970577029 cites W2044161236 @default.
• W1970577029 cites W2056375233 @default.
• W1970577029 cites W2128118061 @default.
• W1970577029 cites W2132309525 @default.
• W1970577029 cites W2161278579 @default.
• W1970577029 doi "https://doi.org/10.1002/jbmr.5650110611" @default.
• W1970577029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8725177" @default.
• W1970577029 hasPublicationYear "2009" @default.
• W1970577029 type Work @default.
• W1970577029 sameAs 1970577029 @default.
• W1970577029 citedByCount "25" @default.
• W1970577029 countsByYear W19705770292013 @default.
• W1970577029 countsByYear W19705770292014 @default.
• W1970577029 countsByYear W19705770292016 @default.
• W1970577029 countsByYear W19705770292021 @default.
• W1970577029 countsByYear W19705770292023 @default.
• W1970577029 crossrefType "journal-article" @default.
• W1970577029 hasAuthorship W1970577029A5055180025 @default.
• W1970577029 hasAuthorship W1970577029A5082022638 @default.
• W1970577029 hasAuthorship W1970577029A5083825372 @default.
• W1970577029 hasConcept C105702510 @default.
• W1970577029 hasConcept C106487976 @default.
• W1970577029 hasConcept C109523444 @default.
• W1970577029 hasConcept C126322002 @default.
• W1970577029 hasConcept C131075544 @default.
• W1970577029 hasConcept C134018914 @default.
• W1970577029 hasConcept C160160445 @default.
• W1970577029 hasConcept C167814343 @default.
• W1970577029 hasConcept C181199279 @default.
• W1970577029 hasConcept C185592680 @default.
• W1970577029 hasConcept C189165786 @default.
• W1970577029 hasConcept C202751555 @default.
• W1970577029 hasConcept C2777668750 @default.
• W1970577029 hasConcept C2778260815 @default.
• W1970577029 hasConcept C2779335624 @default.
• W1970577029 hasConcept C2780644872 @default.
• W1970577029 hasConcept C2781460891 @default.
• W1970577029 hasConcept C2910422434 @default.
• W1970577029 hasConcept C43617362 @default.
• W1970577029 hasConcept C55493867 @default.
• W1970577029 hasConcept C55728118 @default.
• W1970577029 hasConcept C71924100 @default.
• W1970577029 hasConcept C86492073 @default.
• W1970577029 hasConceptScore W1970577029C105702510 @default.
• W1970577029 hasConceptScore W1970577029C106487976 @default.
• W1970577029 hasConceptScore W1970577029C109523444 @default.
• W1970577029 hasConceptScore W1970577029C126322002 @default.
• W1970577029 hasConceptScore W1970577029C131075544 @default.
• W1970577029 hasConceptScore W1970577029C134018914 @default.
• W1970577029 hasConceptScore W1970577029C160160445 @default.
• W1970577029 hasConceptScore W1970577029C167814343 @default.
• W1970577029 hasConceptScore W1970577029C181199279 @default.
• W1970577029 hasConceptScore W1970577029C185592680 @default.
• W1970577029 hasConceptScore W1970577029C189165786 @default.
• W1970577029 hasConceptScore W1970577029C202751555 @default.
• W1970577029 hasConceptScore W1970577029C2777668750 @default.
• W1970577029 hasConceptScore W1970577029C2778260815 @default.
• W1970577029 hasConceptScore W1970577029C2779335624 @default.
• W1970577029 hasConceptScore W1970577029C2780644872 @default.
• W1970577029 hasConceptScore W1970577029C2781460891 @default.
• W1970577029 hasConceptScore W1970577029C2910422434 @default.
• W1970577029 hasConceptScore W1970577029C43617362 @default.
• W1970577029 hasConceptScore W1970577029C55493867 @default.
• W1970577029 hasConceptScore W1970577029C55728118 @default.
• W1970577029 hasConceptScore W1970577029C71924100 @default.
• W1970577029 hasConceptScore W1970577029C86492073 @default.
• W1970577029 hasIssue "6" @default.
• W1970577029 hasLocation W19705770291 @default.
• W1970577029 hasLocation W19705770292 @default.
• W1970577029 hasOpenAccess W1970577029 @default.
• W1970577029 hasPrimaryLocation W19705770291 @default.
• W1970577029 hasRelatedWork W1966670433 @default.
• W1970577029 hasRelatedWork W1976153148 @default.
• W1970577029 hasRelatedWork W1993345617 @default.
• W1970577029 hasRelatedWork W2039629444 @default.
• W1970577029 hasRelatedWork W2041194446 @default.
• W1970577029 hasRelatedWork W2049722654 @default.
• W1970577029 hasRelatedWork W2089502550 @default.
• W1970577029 hasRelatedWork W2318182450 @default.

• next