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- W1970586931 endingPage "2342" @default.
- W1970586931 startingPage "2333" @default.
- W1970586931 abstract "The nasopharynx of children is often colonised by microorganisms such as Streptococcus pneumoniae (the pneumococcus) that can cause infections including pneumonia and otitis media. In this complex environment, bacteria and viruses may impact each other through antagonistic as well as synergistic interactions. Vaccination may alter colonisation dynamics, evidenced by the rise in non-vaccine serotypes following pneumococcal conjugate vaccination. Discovery of an inverse relationship between S. pneumoniae and Staphylococcus aureus carriage generated concern that pneumococcal vaccination could increase S. aureus carriage and disease. Here we review data on co-colonisation of pathogens in the nasopharynx, focusing on S. pneumoniae and the impact of pneumococcal vaccination. Thus far, pneumococcal vaccination has not had a sustained impact on S. aureus carriage but it is associated with an increase in non-typeable Haemophilus influenzae in acute otitis media aetiology. Advances in bacterial and viral detection methodologies have facilitated research in nasopharyngeal microbiology and will aid investigation of potential vaccine-induced changes, particularly when baseline studies can be conducted prior to pneumococcal vaccine introduction." @default.
- W1970586931 created "2016-06-24" @default.
- W1970586931 creator A5011317413 @default.
- W1970586931 creator A5032374370 @default.
- W1970586931 creator A5050798377 @default.
- W1970586931 creator A5080099666 @default.
- W1970586931 creator A5089345912 @default.
- W1970586931 date "2013-05-01" @default.
- W1970586931 modified "2023-10-11" @default.
- W1970586931 title "Nasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination" @default.
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