Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970610418> ?p ?o ?g. }
- W1970610418 endingPage "57" @default.
- W1970610418 startingPage "48" @default.
- W1970610418 abstract "Recent work has demonstrated that self-repair in the adult brain can be augmented by the infusion of growth factors to activate endogenous neural precursor cells that contribute to new tissue formation and functional recovery in a model of stroke. Using both a genetic model and drug treatment, we demonstrate that immunosuppression mimics the effects of growth factor activation, including tissue regeneration, neural precursor cell migration and functional recovery following ischemic injury. In the absence of growth factor treatment, mice with a functional immune system develop a prominent cavity in the cortex underlying the ischemic injury. In untreated immunodeficient NOD/SCID mice, however, the cortical cavity forms but is then filled with regenerated cortical tissue containing glial cells and subependyma derived neural stem and progenitor cells that migrate from their niche lining the lateral ventricles. The daily administration of Cyclosporine A also results in endogenous neural precursor cell migration and regenerated cortical tissue at the site of the cortical injury. Different from growth factor-treated animals is the finding that the regenerated cortical tissue in immunosuppressed animals is devoid of new neurons. Interestingly, both the growth factor and immunosuppressed (NOD/SCID and Cyclosporine A) treated animals displayed functional behavioural recovery despite the lack of neurogenesis within the regenerated cortical tissue. This article is part of a Special Issue entitled Interaction between repair, disease, & inflammation." @default.
- W1970610418 created "2016-06-24" @default.
- W1970610418 creator A5018536499 @default.
- W1970610418 creator A5034154866 @default.
- W1970610418 creator A5041309043 @default.
- W1970610418 creator A5082879278 @default.
- W1970610418 date "2011-07-01" @default.
- W1970610418 modified "2023-10-15" @default.
- W1970610418 title "Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury" @default.
- W1970610418 cites W1487914405 @default.
- W1970610418 cites W1594425991 @default.
- W1970610418 cites W1733539716 @default.
- W1970610418 cites W1775329494 @default.
- W1970610418 cites W1975160937 @default.
- W1970610418 cites W1975241767 @default.
- W1970610418 cites W1983089266 @default.
- W1970610418 cites W1984947099 @default.
- W1970610418 cites W1985633888 @default.
- W1970610418 cites W1997801266 @default.
- W1970610418 cites W1999816939 @default.
- W1970610418 cites W2004750620 @default.
- W1970610418 cites W2010633131 @default.
- W1970610418 cites W2026985565 @default.
- W1970610418 cites W2027110425 @default.
- W1970610418 cites W2035250926 @default.
- W1970610418 cites W2044376274 @default.
- W1970610418 cites W2047272909 @default.
- W1970610418 cites W2048431655 @default.
- W1970610418 cites W2051799250 @default.
- W1970610418 cites W2054552572 @default.
- W1970610418 cites W2057608998 @default.
- W1970610418 cites W2071969118 @default.
- W1970610418 cites W2072452087 @default.
- W1970610418 cites W2073390876 @default.
- W1970610418 cites W2079356804 @default.
- W1970610418 cites W2083628520 @default.
- W1970610418 cites W2084217262 @default.
- W1970610418 cites W2084749570 @default.
- W1970610418 cites W2084995170 @default.
- W1970610418 cites W2102147114 @default.
- W1970610418 cites W2104934532 @default.
- W1970610418 cites W2108398194 @default.
- W1970610418 cites W2118377972 @default.
- W1970610418 cites W2136755158 @default.
- W1970610418 cites W2140980734 @default.
- W1970610418 cites W2142792453 @default.
- W1970610418 cites W2145430337 @default.
- W1970610418 cites W2148250994 @default.
- W1970610418 cites W2151400960 @default.
- W1970610418 cites W2153533547 @default.
- W1970610418 cites W2168272960 @default.
- W1970610418 doi "https://doi.org/10.1016/j.expneurol.2010.05.018" @default.
- W1970610418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20685361" @default.
- W1970610418 hasPublicationYear "2011" @default.
- W1970610418 type Work @default.
- W1970610418 sameAs 1970610418 @default.
- W1970610418 citedByCount "88" @default.
- W1970610418 countsByYear W19706104182012 @default.
- W1970610418 countsByYear W19706104182013 @default.
- W1970610418 countsByYear W19706104182014 @default.
- W1970610418 countsByYear W19706104182015 @default.
- W1970610418 countsByYear W19706104182016 @default.
- W1970610418 countsByYear W19706104182017 @default.
- W1970610418 countsByYear W19706104182018 @default.
- W1970610418 countsByYear W19706104182019 @default.
- W1970610418 countsByYear W19706104182020 @default.
- W1970610418 countsByYear W19706104182021 @default.
- W1970610418 countsByYear W19706104182022 @default.
- W1970610418 countsByYear W19706104182023 @default.
- W1970610418 crossrefType "journal-article" @default.
- W1970610418 hasAuthorship W1970610418A5018536499 @default.
- W1970610418 hasAuthorship W1970610418A5034154866 @default.
- W1970610418 hasAuthorship W1970610418A5041309043 @default.
- W1970610418 hasAuthorship W1970610418A5082879278 @default.
- W1970610418 hasConcept C124964019 @default.
- W1970610418 hasConcept C136834591 @default.
- W1970610418 hasConcept C142724271 @default.
- W1970610418 hasConcept C1491633281 @default.
- W1970610418 hasConcept C169760540 @default.
- W1970610418 hasConcept C171056886 @default.
- W1970610418 hasConcept C201750760 @default.
- W1970610418 hasConcept C203014093 @default.
- W1970610418 hasConcept C2780252810 @default.
- W1970610418 hasConcept C28328180 @default.
- W1970610418 hasConcept C4746552 @default.
- W1970610418 hasConcept C54355233 @default.
- W1970610418 hasConcept C71924100 @default.
- W1970610418 hasConcept C86803240 @default.
- W1970610418 hasConcept C95444343 @default.
- W1970610418 hasConceptScore W1970610418C124964019 @default.
- W1970610418 hasConceptScore W1970610418C136834591 @default.
- W1970610418 hasConceptScore W1970610418C142724271 @default.
- W1970610418 hasConceptScore W1970610418C1491633281 @default.
- W1970610418 hasConceptScore W1970610418C169760540 @default.
- W1970610418 hasConceptScore W1970610418C171056886 @default.
- W1970610418 hasConceptScore W1970610418C201750760 @default.
- W1970610418 hasConceptScore W1970610418C203014093 @default.
- W1970610418 hasConceptScore W1970610418C2780252810 @default.