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- W1970619210 abstract "Abstract Pharmacological studies have been made in hepatoma patients taking CB10-252, a latent enzyme-activated alkylating agent. Following oral administration, the drug was absorbed rapidly, and peak levels of unmetabolised drug were seen at 1 hr. The parent drug is cleaved by azoreductase to yield an alkylating agent with a very short half-life and stable metabolites. Peak plasma levels of these metabolites were seen at 2 hr with persistence of the compounds for 12 hr. Eight hr after drug administration, 80 per cent of the dose had been eliminated in the urine, the majority in the form of metabolites with only 2 per cent being recovered as unmetabolised drug. Azoreductase activity was demonstrated in normal human liver and in human bone marrow and lymphoid cells. This latter finding may explain the occurrence of myelosuppression observed in several patients. These data indicate that CB10-252 is not a hepatoma-selective alkylating agent, but that the drug is well absorbed following oral administration." @default.
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- W1970619210 date "1977-09-01" @default.
- W1970619210 modified "2023-09-23" @default.
- W1970619210 title "The clinical pharmacology of a hepatoma-specific alkylating agent" @default.
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- W1970619210 doi "https://doi.org/10.1016/0006-2952(77)90150-2" @default.
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