FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970619525> ?p ?o ?g. }

• W1970619525 endingPage "198" @default.
• W1970619525 startingPage "187" @default.
• W1970619525 abstract "A synthetic pentasaccharide, representing the critical sequence required in heparin for binding to antithrombin III (AT III), produces strong anti-factor Xa activity in vitro in the presence of AT III and is devoid of any activity directed towards thrombin. This pentasaccharide provides a unique tool to study the question of whether an agent capable of inhibiting factor Xa but devoid of anti-factor IIa activity in vitro, has the capacity to produce an antithrombotic effect in vivo. We have previously demonstrated in a rabbit stasis thrombosis model using a human serum challenge, a significant antithrombotic effect of the pentasaccharide. This finding and discrepancies with some earlier reports on the antithrombotic actions of other oligosaccharide fragments, led us to extend these studies. Four modifications of the stasis thrombosis model were developed using the following thrombogenic challenges selected for their specified induction sites of thrombosis, thromboplastin, an activated prothrombin complex concentrate, a non-activated prothrombin complex concentrate administered simultaneously with Russell's viper venom, and factor Xa. Dose-dependent antithrombotic responses were obtained in all four systems with ED50 values between 25–43 ug/kg for pentasaccharide as compared to 16–47 ug/kg for heparin. Complete inhibition of induced thrombosis was obtained in all four systems for pentasaccharide. Ex vivo analysis revealed expected anti-factor Xa levels but no anti-factor IIa activity. It is concluded that an oligosaccharide with high anti-factor Xa activity and devoid of anti-factor IIa activity is capable of inhibiting thrombosis induced in rabbit stasis models, but that higher dosages than heparin are required for this effect." @default.
• W1970619525 created "2016-06-24" @default.
• W1970619525 creator A5007859032 @default.
• W1970619525 creator A5024797602 @default.
• W1970619525 creator A5057790688 @default.
• W1970619525 creator A5059046284 @default.
• W1970619525 creator A5074304553 @default.
• W1970619525 creator A5082987101 @default.
• W1970619525 date "1987-04-01" @default.
• W1970619525 modified "2023-10-18" @default.
• W1970619525 title "Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges" @default.
• W1970619525 cites W1524312435 @default.
• W1970619525 cites W1600823549 @default.
• W1970619525 cites W1758269067 @default.
• W1970619525 cites W1964448790 @default.
• W1970619525 cites W1964456670 @default.
• W1970619525 cites W1977417712 @default.
• W1970619525 cites W1987853657 @default.
• W1970619525 cites W1996624014 @default.
• W1970619525 cites W2002586497 @default.
• W1970619525 cites W2012849218 @default.
• W1970619525 cites W2015057125 @default.
• W1970619525 cites W2024483474 @default.
• W1970619525 cites W2025768989 @default.
• W1970619525 cites W2028889338 @default.
• W1970619525 cites W2030145547 @default.
• W1970619525 cites W2038489530 @default.
• W1970619525 cites W2039396916 @default.
• W1970619525 cites W2041182123 @default.
• W1970619525 cites W2046979478 @default.
• W1970619525 cites W2070374634 @default.
• W1970619525 cites W2076305871 @default.
• W1970619525 cites W2083278306 @default.
• W1970619525 cites W2085792404 @default.
• W1970619525 cites W2085904727 @default.
• W1970619525 cites W2086808806 @default.
• W1970619525 cites W2090279732 @default.
• W1970619525 cites W2093491931 @default.
• W1970619525 cites W2112799238 @default.
• W1970619525 cites W2145571644 @default.
• W1970619525 cites W2236078543 @default.
• W1970619525 cites W2406868216 @default.
• W1970619525 cites W2419228285 @default.
• W1970619525 cites W244003087 @default.
• W1970619525 cites W4232831003 @default.
• W1970619525 doi "https://doi.org/10.1016/0049-3848(87)90280-5" @default.
• W1970619525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3603420" @default.
• W1970619525 hasPublicationYear "1987" @default.
• W1970619525 type Work @default.
• W1970619525 sameAs 1970619525 @default.
• W1970619525 citedByCount "87" @default.
• W1970619525 countsByYear W19706195252012 @default.
• W1970619525 countsByYear W19706195252013 @default.
• W1970619525 countsByYear W19706195252015 @default.
• W1970619525 countsByYear W19706195252016 @default.
• W1970619525 countsByYear W19706195252022 @default.
• W1970619525 crossrefType "journal-article" @default.
• W1970619525 hasAuthorship W1970619525A5007859032 @default.
• W1970619525 hasAuthorship W1970619525A5024797602 @default.
• W1970619525 hasAuthorship W1970619525A5057790688 @default.
• W1970619525 hasAuthorship W1970619525A5059046284 @default.
• W1970619525 hasAuthorship W1970619525A5074304553 @default.
• W1970619525 hasAuthorship W1970619525A5082987101 @default.
• W1970619525 hasConcept C126322002 @default.
• W1970619525 hasConcept C150903083 @default.
• W1970619525 hasConcept C185592680 @default.
• W1970619525 hasConcept C202751555 @default.
• W1970619525 hasConcept C203014093 @default.
• W1970619525 hasConcept C207001950 @default.
• W1970619525 hasConcept C26291073 @default.
• W1970619525 hasConcept C2777015399 @default.
• W1970619525 hasConcept C2777292125 @default.
• W1970619525 hasConcept C2777557582 @default.
• W1970619525 hasConcept C2779026020 @default.
• W1970619525 hasConcept C2780868729 @default.
• W1970619525 hasConcept C2909817843 @default.
• W1970619525 hasConcept C55493867 @default.
• W1970619525 hasConcept C71924100 @default.
• W1970619525 hasConcept C86803240 @default.
• W1970619525 hasConcept C89560881 @default.
• W1970619525 hasConcept C98274493 @default.
• W1970619525 hasConceptScore W1970619525C126322002 @default.
• W1970619525 hasConceptScore W1970619525C150903083 @default.
• W1970619525 hasConceptScore W1970619525C185592680 @default.
• W1970619525 hasConceptScore W1970619525C202751555 @default.
• W1970619525 hasConceptScore W1970619525C203014093 @default.
• W1970619525 hasConceptScore W1970619525C207001950 @default.
• W1970619525 hasConceptScore W1970619525C26291073 @default.
• W1970619525 hasConceptScore W1970619525C2777015399 @default.
• W1970619525 hasConceptScore W1970619525C2777292125 @default.
• W1970619525 hasConceptScore W1970619525C2777557582 @default.
• W1970619525 hasConceptScore W1970619525C2779026020 @default.
• W1970619525 hasConceptScore W1970619525C2780868729 @default.
• W1970619525 hasConceptScore W1970619525C2909817843 @default.
• W1970619525 hasConceptScore W1970619525C55493867 @default.
• W1970619525 hasConceptScore W1970619525C71924100 @default.
• W1970619525 hasConceptScore W1970619525C86803240 @default.
• W1970619525 hasConceptScore W1970619525C89560881 @default.

• next