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• W1970631302 abstract "Successful spermatogenesis is dependent on the proper attachment of developing germ cells to Sertoli cells. Manipulation of these interactions by drugs like Adjudin can hamper the development of germ cells and lead to conditions of temporary infertility. Although studies have shown the contraceptive potential of Adjudin, much is not known about its action in the testis. In this study, we sought to investigate the effect of Adjudin on the oxidative status of mammalian testis. Adult male rats were administered with a single dose of Adjudin (50 mg/kg body weight) by oral gavage and were killed at 1, 2, 4, 7, 15, or 30 days of treatment. Adjudin caused a significant increase in the production of hydrogen peroxide and lipid peroxidation from 4 to 7 days after treatment. There was a significant decrease in the activities of anti-oxidant enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase from 4 to 7 days after treatment with Adjudin. However, the state of oxidative stress was less pronounced from 15 to 30 days after Adjudin treatment. The level of androgen binding protein (ABP) remained unchanged following Adjudin treatment. These results show that there is an induction of oxidative stress accompanying adherens junction restructuring which suggests a role for reactive oxygen species in the regulation of these testicular junctions. However, transient elevation in reactive oxygen species levels did not affect androgen transport. Mol. Reprod. Dev. 76: 31–37, 2009. © 2008 Wiley-Liss, Inc." @default.
• W1970631302 created "2016-06-24" @default.
• W1970631302 creator A5049666256 @default.
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• W1970631302 date "2009-01-01" @default.
• W1970631302 modified "2023-10-16" @default.
• W1970631302 title "Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis" @default.
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• W1970631302 doi "https://doi.org/10.1002/mrd.20928" @default.
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