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• W1970638085 abstract "Abstract Purpose: To investigate the associations between dynamic contrast‐enhanced magnetic resonance imaging (DCE MRI) parameters and the Gleason score (GS) for prostate cancer (PCA) with localization information provided by concurrent apparent diffusion coefficient (ADC) maps. Materials and Methods: Forty‐three male patients received MR scans, including diffusion tensor imaging (DTI) and DCE MRI, on a 1.5 T MR system. All patients were confirmed to have PCA in the following biopsy within 2 weeks. ADC maps calculated from DTI were used to colocalize cancerous and noncancerous regions on DCE MRI for perfusion analysis retrospectively. Semiquantitative parameters (peak enhancement, initial gradient, and washout gradient [WG] and quantitative parameters [K trans , ν e , and k ep ]) were calculated and correlated with the GS. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of the perfusion parameters in assessing the aggressiveness of PCA. Results: A total of 41 PCA nodules were included in the analysis. Among all quantitative and semiquantitative parameters, only WG showed significant correlation with GS ( r = −0.75, P < 0.0001). By defining tumor aggressiveness as a GS >6, WG demonstrated a good diagnostic performance, with the area under the ROC curve being 0.88. Under a cutoff point of WG = 0.125 min −1 , the sensitivity and specificity were 0.87 and 0.78, respectively. Conclusion: WG shows a significant association with GS and good diagnostic performance in assessing tumor aggressiveness. Therefore, WG is a potential marker of GS. J. Magn. Reson. Imaging 2012;36:912–919. © 2012 Wiley Periodicals, Inc." @default.
• W1970638085 created "2016-06-24" @default.
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• W1970638085 date "2012-06-18" @default.
• W1970638085 modified "2023-10-17" @default.
• W1970638085 title "Washout gradient in dynamic contrast-enhanced MRI is associated with tumor aggressiveness of prostate cancer" @default.
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• W1970638085 doi "https://doi.org/10.1002/jmri.23723" @default.
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