FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970642081> ?p ?o ?g. }

• W1970642081 endingPage "727" @default.
• W1970642081 startingPage "721" @default.
• W1970642081 abstract "2-(5,5-Dimethyl-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yl)-2-methyl-3,4-dihydro-2H-pyrroline N-oxide {2-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-3,4-dihydro-2-methyl-2H-pyrrole N-oxide, G-CYPMPO} as the stable crystals having gauche conformation was successfully synthesized as a novel 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO)-type spin trap agent. However, the function of G-CYPMPO in vivo is still unclear. Thus, the purpose of this study was to evaluate the effects of G-CYPMPO in an in vivo model of Parkinson's disease (PD). Rats were microinjected with 6-hydroxydopamine (6-OHDA, 32 nmol) in the presence or absence of G-CYPMPO (0.4, 1.2, 4 nmol). We investigated behavioral and histochemical parameters in this rat model of PD. In addition, to examine the effects of G-CYPMPO against oxidative stress, we used electron spin resonance (ESR) spectrometry. Intranigral injection of 6-OHDA alone induced a massive loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra pars compacta (SNpc). Co-microinjection of G-CYPMPO significantly prevented 6-OHDA-induced dopaminergic neurodegeneration and behavioral impairments. Immunoreactivities for glial markers, such as cluster of differentiation antigen-11b (CD11b) and glial fibrillary acidic protein (GFAP), were notably detected in the SNpc of rats injected with 6-OHDA alone. These immunoreactivities were markedly suppressed by the co-microinjection of G-CYPMPO, similar to the results in vehicle-treated rats. In addition, G-CYPMPO directly trapped hydroxyl radical (OH) generated from 6-OHDA and Fe2+ in a concentration-dependent manner. These results suggest that G-CYPMPO attenuates 6-OHDA-induced dopaminergic neurodegeneration in a rat model of PD, and is a useful tool for biological research." @default.
• W1970642081 created "2016-06-24" @default.
• W1970642081 creator A5008610426 @default.
• W1970642081 creator A5010952206 @default.
• W1970642081 creator A5024903237 @default.
• W1970642081 creator A5026275950 @default.
• W1970642081 creator A5032064265 @default.
• W1970642081 creator A5061628159 @default.
• W1970642081 creator A5063790948 @default.
• W1970642081 creator A5081384952 @default.
• W1970642081 creator A5084764393 @default.
• W1970642081 date "2011-05-01" @default.
• W1970642081 modified "2023-09-27" @default.
• W1970642081 title "Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper" @default.
• W1970642081 cites W1964517676 @default.
• W1970642081 cites W1967282017 @default.
• W1970642081 cites W1967922486 @default.
• W1970642081 cites W1974924674 @default.
• W1970642081 cites W1979054164 @default.
• W1970642081 cites W1981425049 @default.
• W1970642081 cites W1984693449 @default.
• W1970642081 cites W1985613988 @default.
• W1970642081 cites W1986623863 @default.
• W1970642081 cites W1987740832 @default.
• W1970642081 cites W1991691896 @default.
• W1970642081 cites W2002965542 @default.
• W1970642081 cites W2003674452 @default.
• W1970642081 cites W2009583207 @default.
• W1970642081 cites W2011850283 @default.
• W1970642081 cites W2013712742 @default.
• W1970642081 cites W2024921655 @default.
• W1970642081 cites W2041337712 @default.
• W1970642081 cites W2055439774 @default.
• W1970642081 cites W2066113689 @default.
• W1970642081 cites W2068712507 @default.
• W1970642081 cites W2075708068 @default.
• W1970642081 cites W2079231229 @default.
• W1970642081 cites W2092485952 @default.
• W1970642081 cites W2097862184 @default.
• W1970642081 cites W2109759840 @default.
• W1970642081 cites W2145664571 @default.
• W1970642081 cites W2161325655 @default.
• W1970642081 doi "https://doi.org/10.1016/j.neuint.2011.02.013" @default.
• W1970642081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21333707" @default.
• W1970642081 hasPublicationYear "2011" @default.
• W1970642081 type Work @default.
• W1970642081 sameAs 1970642081 @default.
• W1970642081 citedByCount "5" @default.
• W1970642081 countsByYear W19706420812012 @default.
• W1970642081 countsByYear W19706420812018 @default.
• W1970642081 countsByYear W19706420812019 @default.
• W1970642081 crossrefType "journal-article" @default.
• W1970642081 hasAuthorship W1970642081A5008610426 @default.
• W1970642081 hasAuthorship W1970642081A5010952206 @default.
• W1970642081 hasAuthorship W1970642081A5024903237 @default.
• W1970642081 hasAuthorship W1970642081A5026275950 @default.
• W1970642081 hasAuthorship W1970642081A5032064265 @default.
• W1970642081 hasAuthorship W1970642081A5061628159 @default.
• W1970642081 hasAuthorship W1970642081A5063790948 @default.
• W1970642081 hasAuthorship W1970642081A5081384952 @default.
• W1970642081 hasAuthorship W1970642081A5084764393 @default.
• W1970642081 hasConcept C126322002 @default.
• W1970642081 hasConcept C134018914 @default.
• W1970642081 hasConcept C137183658 @default.
• W1970642081 hasConcept C159167319 @default.
• W1970642081 hasConcept C178790620 @default.
• W1970642081 hasConcept C181199279 @default.
• W1970642081 hasConcept C185592680 @default.
• W1970642081 hasConcept C204232928 @default.
• W1970642081 hasConcept C25498285 @default.
• W1970642081 hasConcept C2776773494 @default.
• W1970642081 hasConcept C2776925932 @default.
• W1970642081 hasConcept C2778674702 @default.
• W1970642081 hasConcept C2779134260 @default.
• W1970642081 hasConcept C2779491297 @default.
• W1970642081 hasConcept C2780495277 @default.
• W1970642081 hasConcept C2780938664 @default.
• W1970642081 hasConcept C2911016594 @default.
• W1970642081 hasConcept C29730261 @default.
• W1970642081 hasConcept C513476851 @default.
• W1970642081 hasConcept C55493867 @default.
• W1970642081 hasConcept C71924100 @default.
• W1970642081 hasConcept C86803240 @default.
• W1970642081 hasConceptScore W1970642081C126322002 @default.
• W1970642081 hasConceptScore W1970642081C134018914 @default.
• W1970642081 hasConceptScore W1970642081C137183658 @default.
• W1970642081 hasConceptScore W1970642081C159167319 @default.
• W1970642081 hasConceptScore W1970642081C178790620 @default.
• W1970642081 hasConceptScore W1970642081C181199279 @default.
• W1970642081 hasConceptScore W1970642081C185592680 @default.
• W1970642081 hasConceptScore W1970642081C204232928 @default.
• W1970642081 hasConceptScore W1970642081C25498285 @default.
• W1970642081 hasConceptScore W1970642081C2776773494 @default.
• W1970642081 hasConceptScore W1970642081C2776925932 @default.
• W1970642081 hasConceptScore W1970642081C2778674702 @default.
• W1970642081 hasConceptScore W1970642081C2779134260 @default.
• W1970642081 hasConceptScore W1970642081C2779491297 @default.
• W1970642081 hasConceptScore W1970642081C2780495277 @default.

• next