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• W1970642176 endingPage "e79416" @default.
• W1970642176 startingPage "e79416" @default.
• W1970642176 abstract "Neuroinflammation contributes to many neurologic disorders including Alzheimer's disease, multiple sclerosis, and stroke. Microglia is brain resident myeloid cells and have emerged as a key driver of the neuroinflammatory responses. MicroRNAs (miRNAs) provide a novel layer of gene regulation and play a critical role in regulating the inflammatory response of peripheral macrophages. However, little is known about the miRNA in inflammatory activation of microglia. To elucidate the role that miRNAs have on microglial phenotypes under classical (M1) or alternative (M2) activation under lipopolysaccharide ('M1'-skewing) and interleukin-4 ('M2a'-skewing) stimulation conditions, we performed microarray expression profiling and bioinformatics analysis of both mRNA and miRNA using primary cultured murine microglia. miR-689, miR-124, and miR-155 were the most strongly associated miRNAs predicted to mediate pro-inflammatory pathways and M1-like activation phenotype. miR-155, the most strongly up-regulated miRNA, regulates the signal transducer and activator of transcription 3 signaling pathway enabling the late phase response to M1-skewing stimulation. Reduced expression in miR-689 and miR-124 are associated with dis-inhibition of many canonical inflammatory pathways. miR-124, miR-711, miR-145 are the strongly associated miRNAs predicted to mediate anti-inflammatory pathways and M2-like activation phenotype. Reductions in miR-711 and miR-124 may regulate inflammatory signaling pathways and peroxisome proliferator-activated receptor-gamma pathway. miR-145 potentially regulate peripheral monocyte/macrophage differentiation and faciliate the M2-skewing phenotype. Overall, through combined miRNA and mRNA expression profiling and bioinformatics analysis we have identified six miRNAs and their putative roles in M1 and M2-skewing of microglial activation through different signaling pathways." @default.
• W1970642176 created "2016-06-24" @default.
• W1970642176 creator A5008524903 @default.
• W1970642176 creator A5036717247 @default.
• W1970642176 creator A5078645107 @default.
• W1970642176 date "2013-11-11" @default.
• W1970642176 modified "2023-09-30" @default.
• W1970642176 title "Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia" @default.
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• W1970642176 cites W1605085109 @default.
• W1970642176 cites W1653545152 @default.
• W1970642176 cites W1923917571 @default.
• W1970642176 cites W1962869168 @default.
• W1970642176 cites W1967725460 @default.
• W1970642176 cites W1968008181 @default.
• W1970642176 cites W1969948192 @default.
• W1970642176 cites W1971913084 @default.
• W1970642176 cites W1983382984 @default.
• W1970642176 cites W1987015752 @default.
• W1970642176 cites W1987052134 @default.
• W1970642176 cites W1989553234 @default.
• W1970642176 cites W1994910241 @default.
• W1970642176 cites W1995082021 @default.
• W1970642176 cites W2001713238 @default.
• W1970642176 cites W2001717792 @default.
• W1970642176 cites W2003458001 @default.
• W1970642176 cites W2004492484 @default.
• W1970642176 cites W2006505402 @default.
• W1970642176 cites W2007222211 @default.
• W1970642176 cites W2010037905 @default.
• W1970642176 cites W2012894610 @default.
• W1970642176 cites W2014510815 @default.
• W1970642176 cites W2014652130 @default.
• W1970642176 cites W2020744745 @default.
• W1970642176 cites W2021786299 @default.
• W1970642176 cites W2023741270 @default.
• W1970642176 cites W2026122111 @default.
• W1970642176 cites W2026141598 @default.
• W1970642176 cites W2031084334 @default.
• W1970642176 cites W2031471804 @default.
• W1970642176 cites W2033369082 @default.
• W1970642176 cites W2033561829 @default.
• W1970642176 cites W2034959869 @default.
• W1970642176 cites W2035908500 @default.
• W1970642176 cites W2038164903 @default.
• W1970642176 cites W2038180405 @default.
• W1970642176 cites W2039692123 @default.
• W1970642176 cites W2042422934 @default.
• W1970642176 cites W2043174118 @default.
• W1970642176 cites W2044832480 @default.
• W1970642176 cites W2045262404 @default.
• W1970642176 cites W2049772720 @default.
• W1970642176 cites W2049804522 @default.
• W1970642176 cites W2061123122 @default.
• W1970642176 cites W2067267561 @default.
• W1970642176 cites W2072999024 @default.
• W1970642176 cites W2073387289 @default.
• W1970642176 cites W2073531000 @default.
• W1970642176 cites W2075860675 @default.
• W1970642176 cites W2077783001 @default.
• W1970642176 cites W2080067668 @default.
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• W1970642176 cites W2097314370 @default.
• W1970642176 cites W2099300133 @default.
• W1970642176 cites W2100770448 @default.
• W1970642176 cites W2103146402 @default.
• W1970642176 cites W2106251332 @default.
• W1970642176 cites W2107997122 @default.
• W1970642176 cites W2116197526 @default.
• W1970642176 cites W2122000781 @default.
• W1970642176 cites W2124050695 @default.
• W1970642176 cites W2124957695 @default.
• W1970642176 cites W2128194105 @default.
• W1970642176 cites W2136384877 @default.
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• W1970642176 cites W2144160997 @default.
• W1970642176 cites W2146336916 @default.
• W1970642176 cites W2156023352 @default.
• W1970642176 cites W2157393124 @default.
• W1970642176 cites W2158232675 @default.
• W1970642176 cites W2163737661 @default.
• W1970642176 cites W2167485774 @default.
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• W1970642176 doi "https://doi.org/10.1371/journal.pone.0079416" @default.
• W1970642176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823621" @default.
• W1970642176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24244499" @default.
• W1970642176 hasPublicationYear "2013" @default.
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