FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970667271> ?p ?o ?g. }

• W1970667271 endingPage "e24593" @default.
• W1970667271 startingPage "e24593" @default.
• W1970667271 abstract "Background Postoperative ventricular dysfunction (VnD) occurs in 9–20% of coronary artery bypass graft (CABG) surgical patients and is associated with increased postoperative morbidity and mortality. Understanding genetic causes of postoperative VnD should enhance patient risk stratification and improve treatment and prevention strategies. We aimed to determine if genetic variants associate with occurrence of in-hospital VnD after CABG surgery. Methods A genome-wide association study identified single nucleotide polymorphisms (SNPs) associated with postoperative VnD in male subjects of European ancestry undergoing isolated primary CABG surgery with cardiopulmonary bypass. VnD was defined as the need for ≥2 inotropes or mechanical ventricular support after CABG surgery. Validated SNPs were assessed further in two replication CABG cohorts and meta-analysis was performed. Results Over 100 SNPs were associated with VnD (P<10−4), with one SNP (rs17691914) encoded at 3p22.3 reaching genome-wide significance (Padditive model = 2.14×10−8). Meta-analysis of validation and replication study data for 17 SNPs identified three SNPs associated with increased risk for developing postoperative VnD after adjusting for clinical risk factors. These SNPs are located at 3p22.3 (rs17691914, ORadditive model = 2.01, P = 0.0002), 3p14.2 (rs17061085, ORadditive model = 1.70, P = 0.0001) and 11q23.2 (rs12279572, ORrecessive model = 2.19, P = 0.001). Conclusions No SNPs were consistently associated with strong risk (ORadditive model>2.1) of developing in-hospital VnD after CABG surgery. However, three genetic loci identified by meta-analysis were more modestly associated with development of postoperative VnD. Studies of larger cohorts to assess these loci as well as to define other genetic mechanisms and related biology that link genetic variants to postoperative ventricular dysfunction are warranted." @default.
• W1970667271 created "2016-06-24" @default.
• W1970667271 creator A5003221869 @default.
• W1970667271 creator A5004216670 @default.
• W1970667271 creator A5005091829 @default.
• W1970667271 creator A5011778868 @default.
• W1970667271 creator A5021544196 @default.
• W1970667271 creator A5021979803 @default.
• W1970667271 creator A5030984711 @default.
• W1970667271 creator A5040452268 @default.
• W1970667271 creator A5045246740 @default.
• W1970667271 creator A5046535273 @default.
• W1970667271 creator A5049324919 @default.
• W1970667271 creator A5058070931 @default.
• W1970667271 creator A5058141203 @default.
• W1970667271 creator A5063843642 @default.
• W1970667271 creator A5077078280 @default.
• W1970667271 creator A5085813802 @default.
• W1970667271 creator A5088899338 @default.
• W1970667271 date "2011-09-30" @default.
• W1970667271 modified "2023-09-26" @default.
• W1970667271 title "Genome-Wide Assessment for Genetic Variants Associated with Ventricular Dysfunction after Primary Coronary Artery Bypass Graft Surgery" @default.
• W1970667271 cites W1893505981 @default.
• W1970667271 cites W1976644985 @default.
• W1970667271 cites W1993680619 @default.
• W1970667271 cites W2009832528 @default.
• W1970667271 cites W2012244452 @default.
• W1970667271 cites W2016198268 @default.
• W1970667271 cites W2016805904 @default.
• W1970667271 cites W2018822649 @default.
• W1970667271 cites W2024020853 @default.
• W1970667271 cites W2025142408 @default.
• W1970667271 cites W2046640084 @default.
• W1970667271 cites W2051192868 @default.
• W1970667271 cites W2054153086 @default.
• W1970667271 cites W2055012964 @default.
• W1970667271 cites W2068459121 @default.
• W1970667271 cites W2072841444 @default.
• W1970667271 cites W2098192568 @default.
• W1970667271 cites W2120451046 @default.
• W1970667271 cites W2134783591 @default.
• W1970667271 cites W2141561295 @default.
• W1970667271 cites W2152164721 @default.
• W1970667271 cites W2161633633 @default.
• W1970667271 cites W2614781785 @default.
• W1970667271 doi "https://doi.org/10.1371/journal.pone.0024593" @default.
• W1970667271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3184087" @default.
• W1970667271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21980348" @default.
• W1970667271 hasPublicationYear "2011" @default.
• W1970667271 type Work @default.
• W1970667271 sameAs 1970667271 @default.
• W1970667271 citedByCount "5" @default.
• W1970667271 countsByYear W19706672712013 @default.
• W1970667271 countsByYear W19706672712014 @default.
• W1970667271 countsByYear W19706672712017 @default.
• W1970667271 countsByYear W19706672712018 @default.
• W1970667271 crossrefType "journal-article" @default.
• W1970667271 hasAuthorship W1970667271A5003221869 @default.
• W1970667271 hasAuthorship W1970667271A5004216670 @default.
• W1970667271 hasAuthorship W1970667271A5005091829 @default.
• W1970667271 hasAuthorship W1970667271A5011778868 @default.
• W1970667271 hasAuthorship W1970667271A5021544196 @default.
• W1970667271 hasAuthorship W1970667271A5021979803 @default.
• W1970667271 hasAuthorship W1970667271A5030984711 @default.
• W1970667271 hasAuthorship W1970667271A5040452268 @default.
• W1970667271 hasAuthorship W1970667271A5045246740 @default.
• W1970667271 hasAuthorship W1970667271A5046535273 @default.
• W1970667271 hasAuthorship W1970667271A5049324919 @default.
• W1970667271 hasAuthorship W1970667271A5058070931 @default.
• W1970667271 hasAuthorship W1970667271A5058141203 @default.
• W1970667271 hasAuthorship W1970667271A5063843642 @default.
• W1970667271 hasAuthorship W1970667271A5077078280 @default.
• W1970667271 hasAuthorship W1970667271A5085813802 @default.
• W1970667271 hasAuthorship W1970667271A5088899338 @default.
• W1970667271 hasBestOaLocation W19706672711 @default.
• W1970667271 hasConcept C104317684 @default.
• W1970667271 hasConcept C126322002 @default.
• W1970667271 hasConcept C135763542 @default.
• W1970667271 hasConcept C139275648 @default.
• W1970667271 hasConcept C141071460 @default.
• W1970667271 hasConcept C153209595 @default.
• W1970667271 hasConcept C164705383 @default.
• W1970667271 hasConcept C2775901492 @default.
• W1970667271 hasConcept C2776820930 @default.
• W1970667271 hasConcept C2778881276 @default.
• W1970667271 hasConcept C2992519594 @default.
• W1970667271 hasConcept C54355233 @default.
• W1970667271 hasConcept C71924100 @default.
• W1970667271 hasConcept C86803240 @default.
• W1970667271 hasConceptScore W1970667271C104317684 @default.
• W1970667271 hasConceptScore W1970667271C126322002 @default.
• W1970667271 hasConceptScore W1970667271C135763542 @default.
• W1970667271 hasConceptScore W1970667271C139275648 @default.
• W1970667271 hasConceptScore W1970667271C141071460 @default.
• W1970667271 hasConceptScore W1970667271C153209595 @default.
• W1970667271 hasConceptScore W1970667271C164705383 @default.
• W1970667271 hasConceptScore W1970667271C2775901492 @default.
• W1970667271 hasConceptScore W1970667271C2776820930 @default.

• next