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- W1970670902 abstract "The Cantoblanco Workshop on the Initiation of Antigen Receptor Signaling took place between 20 and 22 October 2008, in Cantoblanco, Madrid, Spain, and was organized by B. Alarcon, M. Davis & A. Weiss.![][1] See Glossary for abbreviations used in this articleIn the back of our minds, we all know how antigen receptors trigger the activation of T‐ and B‐lymphocytes; it seems relatively well worked out. The binding of an antigen to the T‐cell receptor (TCR) and the B‐cell receptor (BCR) results in the phosphorylation of the cytoplasmic domains of these receptors, and off the cells go. Yet how exactly does that happen?For a group of researchers gathered in Madrid, Spain, in the autumn of 2008, that was the question. How does antigen binding to the ectodomains of the TCR and the BCR change the receptors so as to initiate intracellular signalling? Since the discovery of the TCR and the BCR, immunologists have learned a tremendous amount about the signalling cascades that are triggered by antigen binding and ultimately lead to T‐cell and B‐cell activation. However, the mechanisms that translate antigen binding into intracellular signalling remain among the real mysteries of adaptive immunity. How can that be if the mechanisms underlying the activation of a range of receptors—such as growth factor receptors—have been well worked out? In contrast to these conventional receptors, several unique characteristics of antigen receptors suggest that their inner workings are more complicated, including the enormous variability of their antigen‐binding domains and the need to learn to discriminate self from non‐self. How do the numerous unique interactions of antigens with the TCRs and BCRs expressed by each lymphocyte converge on a common change in the intracellular domains of the receptors that is sensitive to foreign antigens, but not self?To foster a discussion of antigen‐receptor activation, … [1]: /embed/graphic-1.gif" @default.
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- W1970670902 date "2009-03-13" @default.
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- W1970670902 title "Change we can believe in—of the conformational type" @default.
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- W1970670902 doi "https://doi.org/10.1038/embor.2009.26" @default.
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!["The Cantoblanco Workshop on the Initiation of Antigen Receptor Signaling took place between 20 and 22 October 2008, in Cantoblanco, Madrid, Spain, and was organized by B. Alarcon, M. Davis & A. Weiss.![][1] See Glossary for abbreviations used in this articleIn the back of our minds, we all know how antigen receptors trigger the activation of T‐ and B‐lymphocytes; it seems relatively well worked out. The binding of an antigen to the T‐cell receptor (TCR) and the B‐cell receptor (BCR) results in the phosphorylation of the cytoplasmic domains of these receptors, and off the cells go. Yet how exactly does that happen?For a group of researchers gathered in Madrid, Spain, in the autumn of 2008, that was the question. How does antigen binding to the ectodomains of the TCR and the BCR change the receptors so as to initiate intracellular signalling? Since the discovery of the TCR and the BCR, immunologists have learned a tremendous amount about the signalling cascades that are triggered by antigen binding and ultimately lead to T‐cell and B‐cell activation. However, the mechanisms that translate antigen binding into intracellular signalling remain among the real mysteries of adaptive immunity. How can that be if the mechanisms underlying the activation of a range of receptors—such as growth factor receptors—have been well worked out? In contrast to these conventional receptors, several unique characteristics of antigen receptors suggest that their inner workings are more complicated, including the enormous variability of their antigen‐binding domains and the need to learn to discriminate self from non‐self. How do the numerous unique interactions of antigens with the TCRs and BCRs expressed by each lymphocyte converge on a common change in the intracellular domains of the receptors that is sensitive to foreign antigens, but not self?To foster a discussion of antigen‐receptor activation, … [1]: /embed/graphic-1.gif"](?object=%22The%20Cantoblanco%20Workshop%20on%20the%20Initiation%20of%20Antigen%20Receptor%20Signaling%20took%20place%20between%2020%20and%2022%20October%202008%2C%20in%20Cantoblanco%2C%20Madrid%2C%20Spain%2C%20and%20was%20organized%20by%20B.%20Alarcon%2C%20M.%20Davis%20%26%20A.%20Weiss.!%5B%5D%5B1%5D%20See%20Glossary%20for%20abbreviations%20used%20in%20this%20articleIn%20the%20back%20of%20our%20minds%2C%20we%20all%20know%20how%20antigen%20receptors%20trigger%20the%20activation%20of%20T%E2%80%90%20and%20B%E2%80%90lymphocytes%3B%20it%20seems%20relatively%20well%20worked%20out.%20The%20binding%20of%20an%20antigen%20to%20the%20T%E2%80%90cell%20receptor%20(TCR)%20and%20the%20B%E2%80%90cell%20receptor%20(BCR)%20results%20in%20the%20phosphorylation%20of%20the%20cytoplasmic%20domains%20of%20these%20receptors%2C%20and%20off%20the%20cells%20go.%20Yet%20how%20exactly%20does%20that%20happen%3FFor%20a%20group%20of%20researchers%20gathered%20in%20Madrid%2C%20Spain%2C%20in%20the%20autumn%20of%202008%2C%20that%20was%20the%20question.%20How%20does%20antigen%20binding%20to%20the%20ectodomains%20of%20the%20TCR%20and%20the%20BCR%20change%20the%20receptors%20so%20as%20to%20initiate%20intracellular%20signalling%3F%20Since%20the%20discovery%20of%20the%20TCR%20and%20the%20BCR%2C%20immunologists%20have%20learned%20a%20tremendous%20amount%20about%20the%20signalling%20cascades%20that%20are%20triggered%20by%20antigen%20binding%20and%20ultimately%20lead%20to%20T%E2%80%90cell%20and%20B%E2%80%90cell%20activation.%20However%2C%20the%20mechanisms%20that%20translate%20antigen%20binding%20into%20intracellular%20signalling%20remain%20among%20the%20real%20mysteries%20of%20adaptive%20immunity.%20How%20can%20that%20be%20if%20the%20mechanisms%20underlying%20the%20activation%20of%20a%20range%20of%20receptors%E2%80%94such%20as%20growth%20factor%20receptors%E2%80%94have%20been%20well%20worked%20out%3F%20In%20contrast%20to%20these%20conventional%20receptors%2C%20several%20unique%20characteristics%20of%20antigen%20receptors%20suggest%20that%20their%20inner%20workings%20are%20more%20complicated%2C%20including%20the%20enormous%20variability%20of%20their%20antigen%E2%80%90binding%20domains%20and%20the%20need%20to%20learn%20to%20discriminate%20self%20from%20non%E2%80%90self.%20How%20do%20the%20numerous%20unique%20interactions%20of%20antigens%20with%20the%20TCRs%20and%20BCRs%20expressed%20by%20each%20lymphocyte%20converge%20on%20a%20common%20change%20in%20the%20intracellular%20domains%20of%20the%20receptors%20that%20is%20sensitive%20to%20foreign%20antigens%2C%20but%20not%20self%3FTo%20foster%20a%20discussion%20of%20antigen%E2%80%90receptor%20activation%2C%20%E2%80%A6%20%5B1%5D%3A%20%2Fembed%2Fgraphic-1.gif%22){kind=link}