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- W1970673282 abstract "Chronic granulomatous disease (CGD) is an inherited disorder, characterized by defects in superoxide-generating NADPH oxidase of phagocytes. The genetic defects in CGD induce failure to activate the respiratory burst in the phagocytes, leading to severe recurrent infections and unexplained prolonged inflammatory reactions that may produce granulomatous lesions. A noble advance in curative therapy for CGD is hematopoietic stem cell transplantation. Since the most common site of involvement in CGD is the lung, the pulmonologists (pediatrics or adult) may be among the first to recognize the pattern of infection, inflammation and granuloma formation, leading to diagnosis of CGD. Pulmonologists need to be aware of different lung manifestations of CGD." @default.
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- W1970673282 date "2013-02-01" @default.
- W1970673282 modified "2023-10-14" @default.
- W1970673282 title "Pulmonary manifestations of chronic granulomatous disease" @default.
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- W1970673282 doi "https://doi.org/10.1586/eci.12.98" @default.
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