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• W1970684480 abstract "No AccessJournal of UrologyClinical Urology: Original Articles1 Nov 1997TREATMENT OF CONDYLOMATA ACUMINATA WITH ORAL ISOTRETINOIN D. Tsambaos, S. Georgiou, A. Monastirli, Th. Sakkis, A. Sagriotis, and G. Goerz D. TsambaosD. Tsambaos More articles by this author , S. GeorgiouS. Georgiou More articles by this author , A. MonastirliA. Monastirli More articles by this author , Th. SakkisTh. Sakkis More articles by this author , A. SagriotisA. Sagriotis More articles by this author , and G. GoerzG. Goerz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64136-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The aim of our study was to evaluate the efficacy and safety of oral isotretinoin in the treatment of condylomata acuminata. Materials and Methods: A total of 56 male patients with a history of condylomata acuminata refractory to at least 1 standard therapeutic regimen was treated orally with isotretinoin (1 mg./kg. daily) during a 3-month period. Results: At the end of treatment 21 of the 53 evaluated patients (39.6%) had complete response, 7 (13.2%) had partial response and 25 (47.1%) had no response. A statistically significant inverse relationship was found between age and area of treated lesions and response to medication. Two complete responders (9.5%) revealed recurrence during the 1-year followup. Conclusions: Oral isotretinoin may be regarded as an effective, fairly well tolerated and noninvasive alternative form of therapy for immature and small condylomata acuminata. References 1 : Therapy of genital human papillomavirus infection. II: methods of treatment. Int. J. Dermatol.1992; 31: 769. 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In: Retinoids: Advances in Basic Research and Therapy. Edited by . New York: Springer-Verlag1981: 407. Google Scholar 8 : Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells. E.M.B.O. J.1992; 11: 2283. Google Scholar 9 : Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells. Proc. Natl. Acad. Sci. U.S.A.1991; 88: 4582. Google Scholar 10 : Retinoid receptors. Recent Prog. Horm. Res.1993; 48: 99. Google Scholar 11 : In vitro modulation of human laryngeal papilloma cell differentiation by retinoic acid. Otolaryngol. Head Neck Surg.1991; 105: 528. Google Scholar 12 : Treatment of extensive virus warts with etretinate (Tigason) in a patient with sarcoidosis. Clin. Exp. Dermatol.1983; 8: 33. Google Scholar 13 : Isotretinoin treatment of recalcitrant warts in an immunosuppressed man. Arch. Dermatol.1986; 122: 19. Google Scholar 14 : Follow-up of patients with epidermodysplasia verruciformis treated with etretinate. Dermatologica1986; 173: 196. Google Scholar 15 : Comparative study of systemic interferon alfa-n1 and isotretinoin in the treatment of resistant condylomata acuminata. J. Amer. Acad. Dermatol.1989; 20: 1023. Google Scholar 16 : Comparative study of systemic interferon alfa-2a plus isotretinoin versus isotretinoin in the treatment of recurrent condyloma acuminatum in men. Urology1995; 45: 857. Google Scholar 17 : An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. Brit. J. Dermatol.1976; 94: 667. Google Scholar 18 : Interferon therapy for condylomata acuminata. New Engl. J. Med.1986; 315: 1059. Google Scholar 19 : Intralesional recombinant alpha-2 interferon for the treatment of patients with condyloma acuminatum or verruca plantaris. Arch. Dermatol.1986; 122: 272. Google Scholar From the Departments of Dermatology, University of Patras, Greece, and Heinrich-Heine University, Dusseldorf, Germany.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBOHLE A, DOEHN C, KAUSCH I and JOCHAM D (2018) TREATMENT OF RECURRENT PENILE CONDYLOMATA ACUMINATA WITH EXTERNAL APPLICATION AND INTRAURETHRAL INSTILLATION OF BACILLUS CALMETTE-GUERINJournal of Urology, VOL. 160, NO. 2, (394-396), Online publication date: 1-Aug-1998. Volume 158Issue 5November 1997Page: 1810-1812 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information D. Tsambaos More articles by this author S. Georgiou More articles by this author A. Monastirli More articles by this author Th. Sakkis More articles by this author A. Sagriotis More articles by this author G. Goerz More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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