FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970698977> ?p ?o ?g. }

• W1970698977 endingPage "13" @default.
• W1970698977 startingPage "1" @default.
• W1970698977 abstract "Misincorporation of non-complementary bases by DNA polymerases is a major source of the occurrence of promutagenic base-pairing errors during DNA replication or repair. Base–base mismatches or loops of extra bases can arise which, if left unrepaired, will generate point or frameshift mutations respectively. To counteract this mutagenic potential, organisms have developed a number of elaborate surveillance and repair strategies which co-operate to maintain the integrity of their genomes. An important replication-associated correction function is provided by the post-replicative mismatch repair system. This system is highly conserved among species and appears to be the major pathway for strand-specific elimination of base–base mispairs and short insertion/deletion loops (IDLs), not only during DNA replication, but also in intermediates of homologous recombination. The efficiency of repair of different base-pairing errors in the DNA varies, and appears to depend on multiple factors, such as the physical structure of the mismatch and sequence context effects. These structural aspects of mismatch repair are poorly understood. In contrast, remarkable progress in understanding the biochemical role of error-recognition proteins has been made in the recent past. In eukaryotes, two heterodimers consisting of MutS-homologous proteins have been shown to share the function of mismatch recognition in vivo and in vitro. A first MutS homologue, MSH2, is present in both heterodimers, and the specificity for mismatch recognition is dictated by its association with either of two other MutS homologues: MSH6 for recognition of base–base mismatches and small IDLs, or MSH3 for recognition of IDLs only. Mismatch repair deficiency in cells can arise through mutation, transcriptional silencing or as a result of imbalanced expression of these genes." @default.
• W1970698977 created "2016-06-24" @default.
• W1970698977 creator A5008715067 @default.
• W1970698977 creator A5023899260 @default.
• W1970698977 date "1999-02-08" @default.
• W1970698977 modified "2023-10-18" @default.
• W1970698977 title "Recognition of DNA alterations by the mismatch repair system" @default.
• W1970698977 cites W1482306189 @default.
• W1970698977 cites W1496112877 @default.
• W1970698977 cites W1506709601 @default.
• W1970698977 cites W1512601207 @default.
• W1970698977 cites W1533214975 @default.
• W1970698977 cites W1546766865 @default.
• W1970698977 cites W1549582007 @default.
• W1970698977 cites W1556127367 @default.
• W1970698977 cites W1561143138 @default.
• W1970698977 cites W1569389754 @default.
• W1970698977 cites W1577360400 @default.
• W1970698977 cites W1577713059 @default.
• W1970698977 cites W1580349966 @default.
• W1970698977 cites W1582040861 @default.
• W1970698977 cites W1589402586 @default.
• W1970698977 cites W1589739980 @default.
• W1970698977 cites W159335997 @default.
• W1970698977 cites W1593968937 @default.
• W1970698977 cites W1605671609 @default.
• W1970698977 cites W1607369454 @default.
• W1970698977 cites W1607454584 @default.
• W1970698977 cites W1619192225 @default.
• W1970698977 cites W1671215381 @default.
• W1970698977 cites W1791809201 @default.
• W1970698977 cites W1862994794 @default.
• W1970698977 cites W1863799659 @default.
• W1970698977 cites W1917300465 @default.
• W1970698977 cites W1934997579 @default.
• W1970698977 cites W1935459338 @default.
• W1970698977 cites W1963581476 @default.
• W1970698977 cites W1965186484 @default.
• W1970698977 cites W1970153568 @default.
• W1970698977 cites W1972221070 @default.
• W1970698977 cites W1976775167 @default.
• W1970698977 cites W1977261259 @default.
• W1970698977 cites W1977284533 @default.
• W1970698977 cites W1977492313 @default.
• W1970698977 cites W1979612448 @default.
• W1970698977 cites W1980462742 @default.
• W1970698977 cites W1982640212 @default.
• W1970698977 cites W1983811214 @default.
• W1970698977 cites W1984661923 @default.
• W1970698977 cites W1984665941 @default.
• W1970698977 cites W1984728878 @default.
• W1970698977 cites W1985882391 @default.
• W1970698977 cites W1986550053 @default.
• W1970698977 cites W1986937402 @default.
• W1970698977 cites W1988094074 @default.
• W1970698977 cites W1988134858 @default.
• W1970698977 cites W1995819860 @default.
• W1970698977 cites W2001585521 @default.
• W1970698977 cites W2005065014 @default.
• W1970698977 cites W2005428197 @default.
• W1970698977 cites W2006974151 @default.
• W1970698977 cites W2007973565 @default.
• W1970698977 cites W2010194741 @default.
• W1970698977 cites W2010752599 @default.
• W1970698977 cites W2012867725 @default.
• W1970698977 cites W2013590008 @default.
• W1970698977 cites W2014571977 @default.
• W1970698977 cites W2014734846 @default.
• W1970698977 cites W2016286342 @default.
• W1970698977 cites W2019288084 @default.
• W1970698977 cites W2019932549 @default.
• W1970698977 cites W2020964893 @default.
• W1970698977 cites W2021281024 @default.
• W1970698977 cites W2026234469 @default.
• W1970698977 cites W2026327431 @default.
• W1970698977 cites W2026388436 @default.
• W1970698977 cites W2028412641 @default.
• W1970698977 cites W2031249741 @default.
• W1970698977 cites W2037223192 @default.
• W1970698977 cites W2037685690 @default.
• W1970698977 cites W2042785161 @default.
• W1970698977 cites W2042932259 @default.
• W1970698977 cites W2043792457 @default.
• W1970698977 cites W2043835251 @default.
• W1970698977 cites W2044198642 @default.
• W1970698977 cites W2044643325 @default.
• W1970698977 cites W2045388444 @default.
• W1970698977 cites W2045630690 @default.
• W1970698977 cites W2051909059 @default.
• W1970698977 cites W2052085780 @default.
• W1970698977 cites W2054046690 @default.
• W1970698977 cites W2055993339 @default.
• W1970698977 cites W2057215523 @default.
• W1970698977 cites W2057767241 @default.
• W1970698977 cites W2062001904 @default.
• W1970698977 cites W2062269069 @default.
• W1970698977 cites W2063858982 @default.
• W1970698977 cites W2064700784 @default.

• next