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- W1970700520 abstract "Background: Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are diseases that share common risk factors. It has been reported that more than half of the patients diagnosed with LC also suffer from COPD. Although COPD is a well known risk factor for LC, the relationship between impaired lung function (LF) and the incidence and progression of pre‐malignant lesions (PMLs) in the central airways is still unclear. Methods: The study included 217 high‐risk patients from a hospital‐based lung cancer surveillance cohort who underwent bronchoscopy with endobronchial biopsy of suspicious lesions, at the Roswell Park Cancer Institute, Buffalo, New York. All patients had lung function measurement within 6 months preceding their baseline biopsy. Baseline histopathology diagnoses included 91squamous metaplasia (SM), 25 squamous dysplasia (SD), 1 in‐situ carcinoma and 5 invasive bronchial carcinoma. Follow‐up bronchoscopy and biopsy were performed on 69 patients. Sixteen patients had a progression of the baseline lesion to a higher grade. The relationship between the baseline LF measures and the incidence and progression of PMLs were examined using regression models. Results: Patients with forced expiratory volume in 1 second percent predicted (FEV1%) of Conclusion: Impaired LF can be a good predictor of occurrence and progression of PMLs in central airways of high risk patients. Spirometric measurement of lung function can be used as an additional tool for identifying target populations in need of more aggressive LC surveillance. Citation Information: Cancer Prev Res 2010;3(1 Suppl):A22." @default.
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- W1970700520 date "2010-01-07" @default.
- W1970700520 modified "2023-09-26" @default.
- W1970700520 title "Abstract A22: Spirometric surveillance for premalignant and malignant bronchial lesions" @default.
- W1970700520 doi "https://doi.org/10.1158/1940-6207.prev-09-a22" @default.
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