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- W1970701059 abstract "We investigated response bias (defined as the decision rule subjects adopt when uncertain) in two experiments using a variant of Signal Detection Theory (SDT) with the discrimination measure d'L and the bias measure CL, under which it is possible to independently evaluate discrimination and response bias. In the first experiment, manics, depressed subjects, and matched psychiatrically normal controls were tested with a recognition memory task with easier and more difficult components before and after 1 month of appropriate pharmacological treatment. This experiment showed that abnormally conservative bias was characteristic of depression and liberal (yea-saying) bias was found in mania regardless of severity of illness; discrimination deficits were found only when symptoms were severe. After treatment, aspects of discrimination worsened in both hypomanic and depressed nonresponders whereas response bias remained unchanged in these patients. In both groups of responders, improvements in response bias were more dramatic than improvements in discrimination. In the second experiment, psychiatrically normal hypertensives were tested with a Stenberg short-term memory scanning task on and off treatment with the centrally active β-blocker propranolol. This experiments showed that treatment with propranolol modeled the bias deficit of depression; that is, bias became more conservative. Both sets of result suggest that disorders of decision may be modulated by β-adrenergic function." @default.
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- W1970701059 date "1990-04-01" @default.
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- W1970701059 title "Disorders of decision in affective disease: An effect of β-adrenergic dysfunction?" @default.
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- W1970701059 doi "https://doi.org/10.1016/0006-3223(90)90463-c" @default.
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