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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970737981> ?p ?o ?g. }

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• W1970737981 abstract "A di-walled molecular umbrella (1a) has been synthesized by acylation of the terminal amino groups of spermidine with cholic acid, followed by condensation with bis(3-O-[N-1,2,3-benzotriazin-4(3H)-one]yl)-5,5'-dithiobis-2-nitrobenzoate (BDTNB), and displacement with glutathione (gamma-Glu-Cys-Gly, GSH). Replacement of the sterol hydroxyls with sulfate groups, prior to displacement with GSH, afforded a hexasulfate analogue 1b. Both conjugates have been found to enter large unilamellar vesicles (200 nm diameter, extrusion) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and to react with entrapped GSH to form oxidized glutathione (GSSG). Evidence for vesicular entry has come from the formation of oxidized glutathione (GSSG) within the interior of the vesicle, the appearance of the thiol form of the umbrella (USH), and the absence of release of GSH into the external aqueous phase. Results that have been obtained from monolayer experiments, together with the fact that the heavily sulfated conjugate is able to cross the phospholipid bilayer, have yielded strong inferential evidence for an umbrella-like action of these molecules as they cross the lipid bilayer." @default.
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• W1970737981 date "2001-05-18" @default.
• W1970737981 modified "2023-09-23" @default.
• W1970737981 title "Molecular Umbrella-Assisted Transport of Glutathione Across a Phospholipid Membrane" @default.
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• W1970737981 doi "https://doi.org/10.1021/ja010124r" @default.
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