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- W1970742017 abstract "B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions." @default.
- W1970742017 created "2016-06-24" @default.
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- W1970742017 date "2002-02-01" @default.
- W1970742017 modified "2023-10-18" @default.
- W1970742017 title "Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation" @default.
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- W1970742017 doi "https://doi.org/10.1016/s1074-7613(02)00274-1" @default.
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