FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970744943> ?p ?o ?g. }

• W1970744943 endingPage "869" @default.
• W1970744943 startingPage "859" @default.
• W1970744943 abstract "Background: HIV-specific cytotoxic T-cell (CTL) responses are defective in HIV-infected patients undergoing antiretroviral therapy (ART). This defect has been attributed to the decreased antigenic burden secondary to ART-associated suppression of HIV-replication, and is responsible for the rebounds of viraemia that occur when patients interrupt therapy. CTL are stimulated by type 1 cytokines and can kill targets via granule-dependent (perforin and granzymes) and -independent (tumour necrosis factor-α, CD95) mechanisms. Methods: Granule-dependent and granule-independent mechanisms of CTL killing, as well as type 1 cytokine production by CD4 T cells, were analysed in 57 chronically HIV-infected ART-treated or ART-untreated individuals. Results: The results can be summarized as follows: the frequency of gp160 (env)-specific interferon-γ-secreting CD8 T lymphocytes correlates positively with HIV viraemia in ART-treated and -untreated patients; Env-specific perforin- and granzymes-expressing CD8 T lymphocytes, and Env-stimulated perforin and granzymes mRNA, are reduced in ART-treated patients independently of HIV viral load and of type 1 cytokine production; tumour necrosis factor-α production is increased in ART-treated individuals; and Env-specific immature CD8+28+27+ cells are only marginally augmented in ART-treated patients, Similar results are observed in cytomegalovirus-specific CD8 T cells and peripheral blood mononuclear cells. Conclusions: A defect of CTL function that selectively affects the granule-dependent mechanisms of lysis is observed in ART-treated individuals. Because interferon-γ production is higher in these patients, this could be a defect primarily involving CTL. These data suggest an independence of CD8 T-cell numbers and their lytic ability in HIV-infected, ART-receiving patients. Immunomodulants are needed to successfully treat HIV infection." @default.
• W1970744943 created "2016-06-24" @default.
• W1970744943 creator A5001173474 @default.
• W1970744943 creator A5004374605 @default.
• W1970744943 creator A5007153512 @default.
• W1970744943 creator A5014801178 @default.
• W1970744943 creator A5017320611 @default.
• W1970744943 creator A5028125287 @default.
• W1970744943 creator A5031288440 @default.
• W1970744943 creator A5064666261 @default.
• W1970744943 creator A5074537783 @default.
• W1970744943 creator A5082117767 @default.
• W1970744943 creator A5084772443 @default.
• W1970744943 date "2004-04-01" @default.
• W1970744943 modified "2023-10-10" @default.
• W1970744943 title "Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals" @default.
• W1970744943 cites W1481708591 @default.
• W1970744943 cites W1517682435 @default.
• W1970744943 cites W1525840776 @default.
• W1970744943 cites W1544655082 @default.
• W1970744943 cites W1555983429 @default.
• W1970744943 cites W1568150013 @default.
• W1970744943 cites W1655510925 @default.
• W1970744943 cites W1829099663 @default.
• W1970744943 cites W1967682437 @default.
• W1970744943 cites W1977876194 @default.
• W1970744943 cites W1982448824 @default.
• W1970744943 cites W2037343680 @default.
• W1970744943 cites W2039751597 @default.
• W1970744943 cites W2054697232 @default.
• W1970744943 cites W2067069532 @default.
• W1970744943 cites W2072056970 @default.
• W1970744943 cites W2077107867 @default.
• W1970744943 cites W2091320091 @default.
• W1970744943 cites W2103182811 @default.
• W1970744943 cites W2119232577 @default.
• W1970744943 cites W2123402662 @default.
• W1970744943 cites W2125582018 @default.
• W1970744943 cites W2129114331 @default.
• W1970744943 cites W2131341516 @default.
• W1970744943 cites W2132207342 @default.
• W1970744943 cites W2138573611 @default.
• W1970744943 cites W2144882745 @default.
• W1970744943 cites W2151303894 @default.
• W1970744943 cites W2151838794 @default.
• W1970744943 cites W2161207924 @default.
• W1970744943 cites W95077935 @default.
• W1970744943 doi "https://doi.org/10.1097/00002030-200404090-00003" @default.
• W1970744943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15060433" @default.
• W1970744943 hasPublicationYear "2004" @default.
• W1970744943 type Work @default.
• W1970744943 sameAs 1970744943 @default.
• W1970744943 citedByCount "39" @default.
• W1970744943 countsByYear W19707449432012 @default.
• W1970744943 countsByYear W19707449432014 @default.
• W1970744943 countsByYear W19707449432015 @default.
• W1970744943 countsByYear W19707449432016 @default.
• W1970744943 countsByYear W19707449432017 @default.
• W1970744943 countsByYear W19707449432018 @default.
• W1970744943 countsByYear W19707449432019 @default.
• W1970744943 countsByYear W19707449432023 @default.
• W1970744943 crossrefType "journal-article" @default.
• W1970744943 hasAuthorship W1970744943A5001173474 @default.
• W1970744943 hasAuthorship W1970744943A5004374605 @default.
• W1970744943 hasAuthorship W1970744943A5007153512 @default.
• W1970744943 hasAuthorship W1970744943A5014801178 @default.
• W1970744943 hasAuthorship W1970744943A5017320611 @default.
• W1970744943 hasAuthorship W1970744943A5028125287 @default.
• W1970744943 hasAuthorship W1970744943A5031288440 @default.
• W1970744943 hasAuthorship W1970744943A5064666261 @default.
• W1970744943 hasAuthorship W1970744943A5074537783 @default.
• W1970744943 hasAuthorship W1970744943A5082117767 @default.
• W1970744943 hasAuthorship W1970744943A5084772443 @default.
• W1970744943 hasBestOaLocation W19707449431 @default.
• W1970744943 hasConcept C147969180 @default.
• W1970744943 hasConcept C154317977 @default.
• W1970744943 hasConcept C159047783 @default.
• W1970744943 hasConcept C167672396 @default.
• W1970744943 hasConcept C183193105 @default.
• W1970744943 hasConcept C202751555 @default.
• W1970744943 hasConcept C203014093 @default.
• W1970744943 hasConcept C2776062744 @default.
• W1970744943 hasConcept C2778690821 @default.
• W1970744943 hasConcept C2779968557 @default.
• W1970744943 hasConcept C2780380082 @default.
• W1970744943 hasConcept C3017875465 @default.
• W1970744943 hasConcept C55493867 @default.
• W1970744943 hasConcept C71924100 @default.
• W1970744943 hasConcept C86803240 @default.
• W1970744943 hasConcept C8891405 @default.
• W1970744943 hasConceptScore W1970744943C147969180 @default.
• W1970744943 hasConceptScore W1970744943C154317977 @default.
• W1970744943 hasConceptScore W1970744943C159047783 @default.
• W1970744943 hasConceptScore W1970744943C167672396 @default.
• W1970744943 hasConceptScore W1970744943C183193105 @default.
• W1970744943 hasConceptScore W1970744943C202751555 @default.
• W1970744943 hasConceptScore W1970744943C203014093 @default.
• W1970744943 hasConceptScore W1970744943C2776062744 @default.

• next