Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970746171> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1970746171 endingPage "416" @default.
- W1970746171 startingPage "405" @default.
- W1970746171 abstract "Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This presents a novel perspective for circadian oscillation occurring due to interactions between clock proteins. Using mathematical models, the authors investigated the mechanism for the transcription-less KaiC phosphorylation cycle. They developed a simple model based on the possible KaiC behavior, which is experimentally suggested by Kitayama et al. (2003, EMBO J, 22:2127–2134). They hypothesized that the KaiC-KaiA complex formation, followed by a decrease in free KaiA molecules, may attenuate the KaiC phosphorylation rate, and it acts as negative feedback in the system. However, this model was shown not to be adequate to generate the KaiC phosphorylation cycle. The authors developed the general version of the model and determined the necessary condition to generate the KaiC phosphorylation cycle. Linear stability analysis revealed that oscillations can occur when the distance of feedback between the recipient reaction and the effector is far enough. Furthermore, they classified negative feedback regulations in the closed system into 2 types: destabilizing inhibition and stabilizing inhibition. Based on this result, the authors predicted that, in addition to the identified states of KaiC, another unknown state must be present between KaiC phosphorylation and the complex formation. By incorporating the unknown state into the previous model, they realized the periodic pattern reminiscent of the KaiC phosphorylation cycle in computer simulation. This result implies that the KaiC-KaiA complex formation requires more than 1 step of posttranslational modification, including phosphorylation or conformational change of KaiC." @default.
- W1970746171 created "2016-06-24" @default.
- W1970746171 creator A5013530666 @default.
- W1970746171 creator A5079886500 @default.
- W1970746171 date "2006-10-01" @default.
- W1970746171 modified "2023-09-24" @default.
- W1970746171 title "Predicting Regulation of the Phosphorylation Cycle of KaiC Clock Protein Using Mathematical Analysis" @default.
- W1970746171 cites W1963684521 @default.
- W1970746171 cites W1968764046 @default.
- W1970746171 cites W1971327350 @default.
- W1970746171 cites W1993390469 @default.
- W1970746171 cites W1997557777 @default.
- W1970746171 cites W2038763999 @default.
- W1970746171 cites W2047697718 @default.
- W1970746171 cites W2054585632 @default.
- W1970746171 cites W2064397441 @default.
- W1970746171 cites W2078461833 @default.
- W1970746171 cites W2081664912 @default.
- W1970746171 cites W2084829143 @default.
- W1970746171 cites W2103238897 @default.
- W1970746171 cites W2137244330 @default.
- W1970746171 cites W2146600670 @default.
- W1970746171 cites W417404130 @default.
- W1970746171 cites W4237997615 @default.
- W1970746171 cites W44043821 @default.
- W1970746171 doi "https://doi.org/10.1177/0748730406291329" @default.
- W1970746171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16998160" @default.
- W1970746171 hasPublicationYear "2006" @default.
- W1970746171 type Work @default.
- W1970746171 sameAs 1970746171 @default.
- W1970746171 citedByCount "34" @default.
- W1970746171 countsByYear W19707461712012 @default.
- W1970746171 countsByYear W19707461712015 @default.
- W1970746171 countsByYear W19707461712017 @default.
- W1970746171 countsByYear W19707461712018 @default.
- W1970746171 countsByYear W19707461712019 @default.
- W1970746171 countsByYear W19707461712020 @default.
- W1970746171 countsByYear W19707461712021 @default.
- W1970746171 countsByYear W19707461712022 @default.
- W1970746171 crossrefType "journal-article" @default.
- W1970746171 hasAuthorship W1970746171A5013530666 @default.
- W1970746171 hasAuthorship W1970746171A5079886500 @default.
- W1970746171 hasConcept C11960822 @default.
- W1970746171 hasConcept C121446783 @default.
- W1970746171 hasConcept C12554922 @default.
- W1970746171 hasConcept C130679736 @default.
- W1970746171 hasConcept C138885662 @default.
- W1970746171 hasConcept C169760540 @default.
- W1970746171 hasConcept C179926584 @default.
- W1970746171 hasConcept C38606739 @default.
- W1970746171 hasConcept C41895202 @default.
- W1970746171 hasConcept C86803240 @default.
- W1970746171 hasConcept C87325107 @default.
- W1970746171 hasConcept C95444343 @default.
- W1970746171 hasConcept C97029542 @default.
- W1970746171 hasConceptScore W1970746171C11960822 @default.
- W1970746171 hasConceptScore W1970746171C121446783 @default.
- W1970746171 hasConceptScore W1970746171C12554922 @default.
- W1970746171 hasConceptScore W1970746171C130679736 @default.
- W1970746171 hasConceptScore W1970746171C138885662 @default.
- W1970746171 hasConceptScore W1970746171C169760540 @default.
- W1970746171 hasConceptScore W1970746171C179926584 @default.
- W1970746171 hasConceptScore W1970746171C38606739 @default.
- W1970746171 hasConceptScore W1970746171C41895202 @default.
- W1970746171 hasConceptScore W1970746171C86803240 @default.
- W1970746171 hasConceptScore W1970746171C87325107 @default.
- W1970746171 hasConceptScore W1970746171C95444343 @default.
- W1970746171 hasConceptScore W1970746171C97029542 @default.
- W1970746171 hasIssue "5" @default.
- W1970746171 hasLocation W19707461711 @default.
- W1970746171 hasLocation W19707461712 @default.
- W1970746171 hasOpenAccess W1970746171 @default.
- W1970746171 hasPrimaryLocation W19707461711 @default.
- W1970746171 hasRelatedWork W1974532162 @default.
- W1970746171 hasRelatedWork W1986944619 @default.
- W1970746171 hasRelatedWork W2015822783 @default.
- W1970746171 hasRelatedWork W2040297364 @default.
- W1970746171 hasRelatedWork W2040457857 @default.
- W1970746171 hasRelatedWork W2064706781 @default.
- W1970746171 hasRelatedWork W2089422320 @default.
- W1970746171 hasRelatedWork W2091481994 @default.
- W1970746171 hasRelatedWork W2766000134 @default.
- W1970746171 hasRelatedWork W3174969338 @default.
- W1970746171 hasVolume "21" @default.
- W1970746171 isParatext "false" @default.
- W1970746171 isRetracted "false" @default.
- W1970746171 magId "1970746171" @default.
- W1970746171 workType "article" @default.