FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970759178> ?p ?o ?g. }

• W1970759178 abstract "The faithful positioning and growth of cells during embryonic development is essential. In this study Seifertet al. demonstrate that inactivation of Sonic Hedgehogduring development of the genital tubercle results in a prolonged G1 phase and a slower rate of growth. During embryonic development, cells are instructed which position to occupy, they interpret these cues as differentiation programmes, and expand these patterns by growth. Sonic hedgehog (Shh) specifies positional identity in many organs; however, its role in growth is not well understood. In this study, we show that inactivation of Shh in external genitalia extends the cell cycle from 8.5 to 14.4 h, and genital growth is reduced by ∼75%. Transient Shh signalling establishes pattern in the genital tubercle; however, transcriptional levels of G1 cell cycle regulators are reduced. Consequently, G1 length is extended, leading to fewer progenitor cells entering S-phase. Cell cycle genes responded similarly to Shh inactivation in genitalia and limbs, suggesting that Shh may regulate growth by similar mechanisms in different organ systems. The finding that Shh regulates cell number by controlling the length of specific cell cycle phases identifies a novel mechanism by which Shh elaborates pattern during appendage development." @default.
• W1970759178 created "2016-06-24" @default.
• W1970759178 creator A5022988545 @default.
• W1970759178 creator A5023919063 @default.
• W1970759178 creator A5063109286 @default.
• W1970759178 creator A5066766859 @default.
• W1970759178 date "2010-06-01" @default.
• W1970759178 modified "2023-10-18" @default.
• W1970759178 title "Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics" @default.
• W1970759178 cites W1616179369 @default.
• W1970759178 cites W1768274470 @default.
• W1970759178 cites W1978281222 @default.
• W1970759178 cites W1991375451 @default.
• W1970759178 cites W1993035406 @default.
• W1970759178 cites W1995867068 @default.
• W1970759178 cites W1997905438 @default.
• W1970759178 cites W2009811048 @default.
• W1970759178 cites W2014254246 @default.
• W1970759178 cites W2015079800 @default.
• W1970759178 cites W2020766548 @default.
• W1970759178 cites W2029714118 @default.
• W1970759178 cites W2030199762 @default.
• W1970759178 cites W2048109276 @default.
• W1970759178 cites W2049941486 @default.
• W1970759178 cites W2053047725 @default.
• W1970759178 cites W2053825702 @default.
• W1970759178 cites W2059614045 @default.
• W1970759178 cites W2072673889 @default.
• W1970759178 cites W2076840943 @default.
• W1970759178 cites W2091752803 @default.
• W1970759178 cites W2094303121 @default.
• W1970759178 cites W2095607199 @default.
• W1970759178 cites W2096747557 @default.
• W1970759178 cites W2098067206 @default.
• W1970759178 cites W2105382539 @default.
• W1970759178 cites W2111197864 @default.
• W1970759178 cites W2116005622 @default.
• W1970759178 cites W2118937247 @default.
• W1970759178 cites W2120665189 @default.
• W1970759178 cites W2126002586 @default.
• W1970759178 cites W2139481908 @default.
• W1970759178 cites W2141078839 @default.
• W1970759178 cites W2141275674 @default.
• W1970759178 cites W2145424250 @default.
• W1970759178 cites W2149879796 @default.
• W1970759178 cites W2154160956 @default.
• W1970759178 cites W2157332716 @default.
• W1970759178 cites W2157461735 @default.
• W1970759178 cites W2158859599 @default.
• W1970759178 cites W2159969199 @default.
• W1970759178 cites W2161282017 @default.
• W1970759178 doi "https://doi.org/10.1038/ncomms1020" @default.
• W1970759178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2964453" @default.
• W1970759178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20975695" @default.
• W1970759178 hasPublicationYear "2010" @default.
• W1970759178 type Work @default.
• W1970759178 sameAs 1970759178 @default.
• W1970759178 citedByCount "67" @default.
• W1970759178 countsByYear W19707591782012 @default.
• W1970759178 countsByYear W19707591782013 @default.
• W1970759178 countsByYear W19707591782014 @default.
• W1970759178 countsByYear W19707591782015 @default.
• W1970759178 countsByYear W19707591782016 @default.
• W1970759178 countsByYear W19707591782017 @default.
• W1970759178 countsByYear W19707591782018 @default.
• W1970759178 countsByYear W19707591782019 @default.
• W1970759178 countsByYear W19707591782020 @default.
• W1970759178 countsByYear W19707591782021 @default.
• W1970759178 countsByYear W19707591782022 @default.
• W1970759178 countsByYear W19707591782023 @default.
• W1970759178 crossrefType "journal-article" @default.
• W1970759178 hasAuthorship W1970759178A5022988545 @default.
• W1970759178 hasAuthorship W1970759178A5023919063 @default.
• W1970759178 hasAuthorship W1970759178A5063109286 @default.
• W1970759178 hasAuthorship W1970759178A5066766859 @default.
• W1970759178 hasBestOaLocation W19707591781 @default.
• W1970759178 hasConcept C104317684 @default.
• W1970759178 hasConcept C145103041 @default.
• W1970759178 hasConcept C1491633281 @default.
• W1970759178 hasConcept C163952510 @default.
• W1970759178 hasConcept C201750760 @default.
• W1970759178 hasConcept C2776637008 @default.
• W1970759178 hasConcept C2778539099 @default.
• W1970759178 hasConcept C28328180 @default.
• W1970759178 hasConcept C29537977 @default.
• W1970759178 hasConcept C54355233 @default.
• W1970759178 hasConcept C62112901 @default.
• W1970759178 hasConcept C62478195 @default.
• W1970759178 hasConcept C86339819 @default.
• W1970759178 hasConcept C86803240 @default.
• W1970759178 hasConcept C95444343 @default.
• W1970759178 hasConceptScore W1970759178C104317684 @default.
• W1970759178 hasConceptScore W1970759178C145103041 @default.
• W1970759178 hasConceptScore W1970759178C1491633281 @default.
• W1970759178 hasConceptScore W1970759178C163952510 @default.
• W1970759178 hasConceptScore W1970759178C201750760 @default.
• W1970759178 hasConceptScore W1970759178C2776637008 @default.
• W1970759178 hasConceptScore W1970759178C2778539099 @default.
• W1970759178 hasConceptScore W1970759178C28328180 @default.
• W1970759178 hasConceptScore W1970759178C29537977 @default.

• next