FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970765475> ?p ?o ?g. }

• W1970765475 endingPage "10" @default.
• W1970765475 startingPage "1" @default.
• W1970765475 abstract "Most of the studies evaluating rash in HIV-positive patients have focused on nonnucleoside reverse transcriptase inhibitors (NNRTI), particularly nevirapine, and little is known about the occurrence of rash and the risk factors for its development in patients receiving regimens not based on NNRTI.We evaluated all cases of rash observed during a 48-week randomized multicentre trial in 1251 nucleoside-experienced patients who started treatment with protease inhibitors (ritonavir or indinavir) at CD4 counts below 50 cells/microL. Incidence rates for rash were calculated according to gender, clinical status, age, use of highly active antiretroviral therapy (HAART), Pneumocystis carinii pneumonia (PCP) prophylaxis and use of individual antiretroviral drugs at enrollment. Differences between groups defined according to the above characteristics were tested for statistical significance using the log-rank test in a Kaplan-Meier survival analysis. All factors that gave results in the univariate analyses below the significance level of 0.05 were included in a multivariate analysis using a Cox regression model.During a follow-up period of 9690 person-months, 66 patients (5.3%) developed rash (0.68 events/100 person-months). In the univariate analyses, risk of rash did not differ with trial treatment (indinavir or ritonavir), clinical status, PCP prophylaxis, or age. During follow-up, rash was observed in 7.5% of enrolled women and in 4.5% of enrolled men (P=0.03). Serious rash occurred in 4.5% of enrolled women and in 1.6% of enrolled men (P=0.003). Use of HAART (P<0.001) and inclusion of zidovudine and of zalcitabine in the prescribed regimen (P=0.02) appeared to be associated with a lower risk of rash. In the multivariate analysis, the variables that remained significantly predictive of rash were gender (risk for women compared to men: 1.65, 95% confidence interval (CI): 1.00-2.72, P=0.048) and use of a non-HAART regimen (risk for non-HAART patients compared to HAART: 2.73, 95% CI: 1.49-5.02, P=0.001).In our study, about 5% of HIV-positive patients who started treatment with protease inhibitors at very low CD4 counts developed rash, generally in the first few weeks after treatment. Risk was significantly higher in women and in patients who did not receive a HAART regimen. Our data indicate that women have a higher risk of rash than men, also with regimens that do not include NNRTI." @default.
• W1970765475 created "2016-06-24" @default.
• W1970765475 creator A5017481279 @default.
• W1970765475 creator A5025787660 @default.
• W1970765475 creator A5027457337 @default.
• W1970765475 creator A5036142555 @default.
• W1970765475 creator A5047777094 @default.
• W1970765475 creator A5048907372 @default.
• W1970765475 creator A5049170322 @default.
• W1970765475 creator A5050535428 @default.
• W1970765475 creator A5054422574 @default.
• W1970765475 creator A5058642476 @default.
• W1970765475 creator A5075956703 @default.
• W1970765475 date "2004-01-01" @default.
• W1970765475 modified "2023-09-26" @default.
• W1970765475 title "Risk factors and occurrence of rash in HIV-positive patients not receiving nonnucleoside reverse transcriptase inhibitor: data from a randomized study evaluating use of protease inhibitors in nucleoside-experienced patients with very low CD4 levels (<50 cells/mmuL)" @default.
• W1970765475 cites W1985646480 @default.
• W1970765475 cites W2000111244 @default.
• W1970765475 cites W2005668317 @default.
• W1970765475 cites W2006774171 @default.
• W1970765475 cites W2018158288 @default.
• W1970765475 cites W2070933534 @default.
• W1970765475 cites W2135950944 @default.
• W1970765475 cites W2152293167 @default.
• W1970765475 cites W2159944585 @default.
• W1970765475 cites W2172715429 @default.
• W1970765475 cites W2315299016 @default.
• W1970765475 doi "https://doi.org/10.1111/j.1468-1293.2004.00177.x" @default.
• W1970765475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14731162" @default.
• W1970765475 hasPublicationYear "2004" @default.
• W1970765475 type Work @default.
• W1970765475 sameAs 1970765475 @default.
• W1970765475 citedByCount "19" @default.
• W1970765475 countsByYear W19707654752012 @default.
• W1970765475 countsByYear W19707654752013 @default.
• W1970765475 countsByYear W19707654752019 @default.
• W1970765475 crossrefType "journal-article" @default.
• W1970765475 hasAuthorship W1970765475A5017481279 @default.
• W1970765475 hasAuthorship W1970765475A5025787660 @default.
• W1970765475 hasAuthorship W1970765475A5027457337 @default.
• W1970765475 hasAuthorship W1970765475A5036142555 @default.
• W1970765475 hasAuthorship W1970765475A5047777094 @default.
• W1970765475 hasAuthorship W1970765475A5048907372 @default.
• W1970765475 hasAuthorship W1970765475A5049170322 @default.
• W1970765475 hasAuthorship W1970765475A5050535428 @default.
• W1970765475 hasAuthorship W1970765475A5054422574 @default.
• W1970765475 hasAuthorship W1970765475A5058642476 @default.
• W1970765475 hasAuthorship W1970765475A5075956703 @default.
• W1970765475 hasConcept C126322002 @default.
• W1970765475 hasConcept C142462285 @default.
• W1970765475 hasConcept C203014093 @default.
• W1970765475 hasConcept C2776452011 @default.
• W1970765475 hasConcept C2777210460 @default.
• W1970765475 hasConcept C2777351918 @default.
• W1970765475 hasConcept C2778570526 @default.
• W1970765475 hasConcept C2779130552 @default.
• W1970765475 hasConcept C2779298103 @default.
• W1970765475 hasConcept C2780727368 @default.
• W1970765475 hasConcept C2993143319 @default.
• W1970765475 hasConcept C3013748606 @default.
• W1970765475 hasConcept C50382708 @default.
• W1970765475 hasConcept C71924100 @default.
• W1970765475 hasConceptScore W1970765475C126322002 @default.
• W1970765475 hasConceptScore W1970765475C142462285 @default.
• W1970765475 hasConceptScore W1970765475C203014093 @default.
• W1970765475 hasConceptScore W1970765475C2776452011 @default.
• W1970765475 hasConceptScore W1970765475C2777210460 @default.
• W1970765475 hasConceptScore W1970765475C2777351918 @default.
• W1970765475 hasConceptScore W1970765475C2778570526 @default.
• W1970765475 hasConceptScore W1970765475C2779130552 @default.
• W1970765475 hasConceptScore W1970765475C2779298103 @default.
• W1970765475 hasConceptScore W1970765475C2780727368 @default.
• W1970765475 hasConceptScore W1970765475C2993143319 @default.
• W1970765475 hasConceptScore W1970765475C3013748606 @default.
• W1970765475 hasConceptScore W1970765475C50382708 @default.
• W1970765475 hasConceptScore W1970765475C71924100 @default.
• W1970765475 hasIssue "1" @default.
• W1970765475 hasLocation W19707654751 @default.
• W1970765475 hasLocation W19707654752 @default.
• W1970765475 hasOpenAccess W1970765475 @default.
• W1970765475 hasPrimaryLocation W19707654751 @default.
• W1970765475 hasRelatedWork W1558093882 @default.
• W1970765475 hasRelatedWork W156181957 @default.
• W1970765475 hasRelatedWork W1970765475 @default.
• W1970765475 hasRelatedWork W1983745989 @default.
• W1970765475 hasRelatedWork W2049738456 @default.
• W1970765475 hasRelatedWork W2083192082 @default.
• W1970765475 hasRelatedWork W2110177975 @default.
• W1970765475 hasRelatedWork W2365525355 @default.
• W1970765475 hasRelatedWork W4229505502 @default.
• W1970765475 hasRelatedWork W4300836247 @default.
• W1970765475 hasVolume "5" @default.
• W1970765475 isParatext "false" @default.
• W1970765475 isRetracted "false" @default.
• W1970765475 magId "1970765475" @default.
• W1970765475 workType "article" @default.