FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970780198> ?p ?o ?g. }

• W1970780198 endingPage "e13174" @default.
• W1970780198 startingPage "e13174" @default.
• W1970780198 abstract "A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack, but may at the same time develop NK cell sensitivity, due to failure to express inhibitory ligands for Ly49 receptors. The extent of MHC class I downregulation needed on normal cells to trigger NK cell effector functions is not known.In this study, we show that cells expressing MHC class I to levels well below half of the host level are tolerated in an in vivo assay in mice. Hemizygous expression (expression from only one allele) of MHC class I was sufficient to induce Ly49 receptor downmodulation on NK cells to a similar degree as homozygous expression, despite a strongly reduced cell surface level of MHC class I. Co-expression of weaker MHC class I ligands in the host did not have any further effect on the degree of Ly49 downmodulation. Furthermore, a single MHC class I allele could downmodulate up to three Ly49 receptors on individual NK cells. Only when NK cells simultaneously expressed several Ly49 receptors and hemizygous MHC class I levels, a putative threshold for Ly49 downmodulation was reached.Collectively, our findings suggest that in interactions between NK cells and normal untransformed cells, MHC class I molecules are in most cases expressed in excess compared to what is functionally needed to ensure self tolerance and to induce maximal Ly49 downmodulation. We speculate that the reason for this is to maintain a safety margin for otherwise normal, autologous cells over a range of MHC class I expression levels, in order to ensure robustness in NK cell tolerance." @default.
• W1970780198 created "2016-06-24" @default.
• W1970780198 creator A5002674606 @default.
• W1970780198 creator A5022625213 @default.
• W1970780198 creator A5026055000 @default.
• W1970780198 creator A5037568604 @default.
• W1970780198 creator A5040973657 @default.
• W1970780198 creator A5041719537 @default.
• W1970780198 creator A5042572710 @default.
• W1970780198 creator A5049645038 @default.
• W1970780198 creator A5076200740 @default.
• W1970780198 creator A5081586079 @default.
• W1970780198 date "2010-10-04" @default.
• W1970780198 modified "2023-10-17" @default.
• W1970780198 title "Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice" @default.
• W1970780198 cites W1603913234 @default.
• W1970780198 cites W1853085945 @default.
• W1970780198 cites W1915834039 @default.
• W1970780198 cites W1942151581 @default.
• W1970780198 cites W1965386484 @default.
• W1970780198 cites W1969950463 @default.
• W1970780198 cites W1972450532 @default.
• W1970780198 cites W1974308995 @default.
• W1970780198 cites W1975922811 @default.
• W1970780198 cites W1976911150 @default.
• W1970780198 cites W1980344216 @default.
• W1970780198 cites W1988547097 @default.
• W1970780198 cites W1989712520 @default.
• W1970780198 cites W1991650736 @default.
• W1970780198 cites W1993319836 @default.
• W1970780198 cites W1994182910 @default.
• W1970780198 cites W1994888826 @default.
• W1970780198 cites W2004923604 @default.
• W1970780198 cites W2006080840 @default.
• W1970780198 cites W2009365255 @default.
• W1970780198 cites W2010789119 @default.
• W1970780198 cites W2017651916 @default.
• W1970780198 cites W2020846586 @default.
• W1970780198 cites W2030019925 @default.
• W1970780198 cites W2039638023 @default.
• W1970780198 cites W2043586257 @default.
• W1970780198 cites W2048245039 @default.
• W1970780198 cites W2054047951 @default.
• W1970780198 cites W2061990213 @default.
• W1970780198 cites W2062851166 @default.
• W1970780198 cites W2066023902 @default.
• W1970780198 cites W2068176895 @default.
• W1970780198 cites W2068517086 @default.
• W1970780198 cites W2070551124 @default.
• W1970780198 cites W2080683076 @default.
• W1970780198 cites W2088513299 @default.
• W1970780198 cites W2093116728 @default.
• W1970780198 cites W2093315368 @default.
• W1970780198 cites W2099153373 @default.
• W1970780198 cites W2106756955 @default.
• W1970780198 cites W2108900633 @default.
• W1970780198 cites W2109081619 @default.
• W1970780198 cites W2111253548 @default.
• W1970780198 cites W2113586042 @default.
• W1970780198 cites W2120988862 @default.
• W1970780198 cites W2131371327 @default.
• W1970780198 cites W2134179828 @default.
• W1970780198 cites W2136516692 @default.
• W1970780198 cites W2137698660 @default.
• W1970780198 cites W2138205821 @default.
• W1970780198 cites W2140917449 @default.
• W1970780198 cites W2150433660 @default.
• W1970780198 cites W2157863714 @default.
• W1970780198 cites W2160174030 @default.
• W1970780198 doi "https://doi.org/10.1371/journal.pone.0013174" @default.
• W1970780198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2949391" @default.
• W1970780198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20957233" @default.
• W1970780198 hasPublicationYear "2010" @default.
• W1970780198 type Work @default.
• W1970780198 sameAs 1970780198 @default.
• W1970780198 citedByCount "22" @default.
• W1970780198 countsByYear W19707801982013 @default.
• W1970780198 countsByYear W19707801982014 @default.
• W1970780198 countsByYear W19707801982015 @default.
• W1970780198 countsByYear W19707801982016 @default.
• W1970780198 countsByYear W19707801982017 @default.
• W1970780198 countsByYear W19707801982018 @default.
• W1970780198 countsByYear W19707801982019 @default.
• W1970780198 countsByYear W19707801982020 @default.
• W1970780198 countsByYear W19707801982021 @default.
• W1970780198 countsByYear W19707801982022 @default.
• W1970780198 crossrefType "journal-article" @default.
• W1970780198 hasAuthorship W1970780198A5002674606 @default.
• W1970780198 hasAuthorship W1970780198A5022625213 @default.
• W1970780198 hasAuthorship W1970780198A5026055000 @default.
• W1970780198 hasAuthorship W1970780198A5037568604 @default.
• W1970780198 hasAuthorship W1970780198A5040973657 @default.
• W1970780198 hasAuthorship W1970780198A5041719537 @default.
• W1970780198 hasAuthorship W1970780198A5042572710 @default.
• W1970780198 hasAuthorship W1970780198A5049645038 @default.
• W1970780198 hasAuthorship W1970780198A5076200740 @default.
• W1970780198 hasAuthorship W1970780198A5081586079 @default.
• W1970780198 hasBestOaLocation W19707801981 @default.

• next