FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970780913> ?p ?o ?g. }

• W1970780913 endingPage "204" @default.
• W1970780913 startingPage "195" @default.
• W1970780913 abstract "Dopamine has several important functions in the retina including a possible role in controlling photoreceptor disk shedding to the RPE. While some cells express a transporter for dopamine, the RPE cell does not, leading us to ask whether the newly described catecholamine transport system, the extraneuronal monoamine transporter (uptake(2)) (also known as organic cation transporter 3 (OCT3), is present in RPE and might function as a transporter for dopamine. OCT3 also accepts histamine as a transportable substrate and so we investigated the interaction of this retinal neurotransmitter with OCT3.OCT3 expression in the mouse eye was analyzed by in situ hybridization, Northern blot analysis and RT-PCR. OCT3 function was analyzed in cultured human ARPE-19 cells by monitoring the uptake of 1-methyl-4-phenyl pyridinium (MPP(+)), a neurotoxin, which is a known substrate for OCT3.In situ hybridization analysis showed that OCT3 is expressed in mouse RPE and in several cell types of the neural retina, including photoreceptor, ganglion, amacrine, and horizontal cells. The expression of OCT3 in RPE was confirmed by Northern blot analysis and RT-PCR. The characteristics of MPP( +) uptake in cultured ARPE-19 cells included the stimulation of transport by alkaline pH, high affinity (K(t) = 28 +/- 4 microM), competition with several cationic drugs and monoamine neurotransmitters and sensitivity to steroids. In addition, the uptake of MPP(+) in RPE cells was inhibited by dopamine and histamine with IC(50) values (concentration needed for 50% inhibition) of 637 +/- 84 microM and 150 +/- 20 microM, respectively. CONCLUSIONS. This study provides the first report on the expression and function of an organic cation transporter, OCT3, in the eye and in particular the RPE. The data have physiological and pharmacological relevance as it is likely that OCT3 participates in the clearance of dopamine and histamine from the subretinal space and may also play a key role in the disposition of the retinal neurotoxin MPP(+)." @default.
• W1970780913 created "2016-06-24" @default.
• W1970780913 creator A5018464783 @default.
• W1970780913 creator A5044459542 @default.
• W1970780913 creator A5083966452 @default.
• W1970780913 creator A5085811083 @default.
• W1970780913 creator A5089000611 @default.
• W1970780913 creator A5091451352 @default.
• W1970780913 date "2000-01-01" @default.
• W1970780913 modified "2023-10-14" @default.
• W1970780913 title "Expression of the extraneuronal monoamine transporter in RPE and neural retina" @default.
• W1970780913 cites W1493374490 @default.
• W1970780913 cites W1799479235 @default.
• W1970780913 cites W1854755157 @default.
• W1970780913 cites W1933153961 @default.
• W1970780913 cites W1958166723 @default.
• W1970780913 cites W1965477067 @default.
• W1970780913 cites W1968906516 @default.
• W1970780913 cites W1984777265 @default.
• W1970780913 cites W1991183604 @default.
• W1970780913 cites W2001198599 @default.
• W1970780913 cites W2014916614 @default.
• W1970780913 cites W2021401103 @default.
• W1970780913 cites W2027579967 @default.
• W1970780913 cites W2036409257 @default.
• W1970780913 cites W2045045758 @default.
• W1970780913 cites W2047393488 @default.
• W1970780913 cites W2052726174 @default.
• W1970780913 cites W2054678225 @default.
• W1970780913 cites W2058921129 @default.
• W1970780913 cites W2066902121 @default.
• W1970780913 cites W2077077576 @default.
• W1970780913 cites W2077628890 @default.
• W1970780913 cites W2081064633 @default.
• W1970780913 cites W2088389476 @default.
• W1970780913 cites W2090196720 @default.
• W1970780913 cites W2133485632 @default.
• W1970780913 cites W2298286985 @default.
• W1970780913 cites W2477582447 @default.
• W1970780913 cites W2736389034 @default.
• W1970780913 cites W48947006 @default.
• W1970780913 cites W572849208 @default.
• W1970780913 cites W1590215417 @default.
• W1970780913 cites W2015939159 @default.
• W1970780913 doi "https://doi.org/10.1076/0271-3683(200003)2031-9ft195" @default.
• W1970780913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10694895" @default.
• W1970780913 hasPublicationYear "2000" @default.
• W1970780913 type Work @default.
• W1970780913 sameAs 1970780913 @default.
• W1970780913 citedByCount "50" @default.
• W1970780913 countsByYear W19707809132012 @default.
• W1970780913 countsByYear W19707809132013 @default.
• W1970780913 countsByYear W19707809132015 @default.
• W1970780913 countsByYear W19707809132016 @default.
• W1970780913 countsByYear W19707809132017 @default.
• W1970780913 countsByYear W19707809132018 @default.
• W1970780913 countsByYear W19707809132019 @default.
• W1970780913 countsByYear W19707809132020 @default.
• W1970780913 countsByYear W19707809132022 @default.
• W1970780913 countsByYear W19707809132023 @default.
• W1970780913 crossrefType "journal-article" @default.
• W1970780913 hasAuthorship W1970780913A5018464783 @default.
• W1970780913 hasAuthorship W1970780913A5044459542 @default.
• W1970780913 hasAuthorship W1970780913A5083966452 @default.
• W1970780913 hasAuthorship W1970780913A5085811083 @default.
• W1970780913 hasAuthorship W1970780913A5089000611 @default.
• W1970780913 hasAuthorship W1970780913A5091451352 @default.
• W1970780913 hasConcept C104317684 @default.
• W1970780913 hasConcept C126322002 @default.
• W1970780913 hasConcept C134018914 @default.
• W1970780913 hasConcept C137183658 @default.
• W1970780913 hasConcept C149011108 @default.
• W1970780913 hasConcept C150194340 @default.
• W1970780913 hasConcept C169760540 @default.
• W1970780913 hasConcept C170493617 @default.
• W1970780913 hasConcept C185592680 @default.
• W1970780913 hasConcept C187714386 @default.
• W1970780913 hasConcept C189613389 @default.
• W1970780913 hasConcept C2775864247 @default.
• W1970780913 hasConcept C2775894120 @default.
• W1970780913 hasConcept C2776755682 @default.
• W1970780913 hasConcept C2777093970 @default.
• W1970780913 hasConcept C2778406628 @default.
• W1970780913 hasConcept C2781334511 @default.
• W1970780913 hasConcept C513476851 @default.
• W1970780913 hasConcept C55493867 @default.
• W1970780913 hasConcept C71924100 @default.
• W1970780913 hasConcept C81439078 @default.
• W1970780913 hasConcept C86803240 @default.
• W1970780913 hasConcept C95444343 @default.
• W1970780913 hasConceptScore W1970780913C104317684 @default.
• W1970780913 hasConceptScore W1970780913C126322002 @default.
• W1970780913 hasConceptScore W1970780913C134018914 @default.
• W1970780913 hasConceptScore W1970780913C137183658 @default.
• W1970780913 hasConceptScore W1970780913C149011108 @default.
• W1970780913 hasConceptScore W1970780913C150194340 @default.
• W1970780913 hasConceptScore W1970780913C169760540 @default.
• W1970780913 hasConceptScore W1970780913C170493617 @default.

• next