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- W1970781217 abstract "To investigate the genetic mechanisms involved in morphological transformation of Syrian hamster embryo (SHE) cells, we have studied the transforming potential of 3-aminobenzamide (3-AB). It was found that prolonged exposure to 3-AB induced morphological transformation of SHE cells as well as C3H10T1½2 cells. At similar doses, 3-AB induced SCEs and chromosomal alterations (gaps, breaks and exchanges) in SHE cells, but no mutations at the hypoxanthine-guanine phosphoribosyl transferase locus. These data strongly suggest morphological transformation can result from genetic alterations other than gene mutations. The possible nature of these genetic alterations involved will be discussed." @default.
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- W1970781217 date "1989-01-01" @default.
- W1970781217 modified "2023-10-01" @default.
- W1970781217 title "Prolonged in vitro exposure of Syrian hamster embryo cells to 3-aminobenzamide induces transformation and chromosomal alterations but not gene mutations" @default.
- W1970781217 doi "https://doi.org/10.1093/carcin/10.2.237" @default.
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