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- W1970781500 abstract "Quenching of 33258 Hoechst fluorescence by 5-bromodeoxyuridine incorporated into chromosomal DNA (S.A. Latt, P.N.A.S. 70:3395, 1973) allows micro-fluorometric differentiation between sister chromatids, documenting the semiconservative distribution of newly replicated DNA. Sister chromatid exchanges are sharply demarcated and can be localized relative to quinacrine banding patterns. While the incidence of exchanges is approximately proportional to meta-phase chromosome length, the majority occur either in interband regions or very near the band-interband junction. Sites of frequent exchange often compare with the locations of radiation-induced breaks and with break points of spontaneous chromosome translocations reported in the literature. Sister chromatid exchanges, analyzed microfluorometrically, are at least 200 times more frequent than breaks and appear to be very sensitive indicators of chromosome damage by the drug mitomycin C. These exchanges might similarly serve to gauge damage due to other chemical agents or radiation, as well as reflect increased susceptibility of chromosome regions to breakage as in Bloom's Syndrome or Fanconi's Anemia." @default.
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- W1970781500 date "1974-04-01" @default.
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- W1970781500 title "MICROFLUOROMETRIC ANALYSIS OF SISTER CHROMATID EXCHANGES, INDICES OF CHROMOSOME FRAGILITY" @default.
- W1970781500 doi "https://doi.org/10.1203/00006450-197404000-00304" @default.
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