Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970782214> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1970782214 endingPage "290" @default.
- W1970782214 startingPage "284" @default.
- W1970782214 abstract "In order to determine the involvement of denervation in endothelium-independent, nitric oxide (NO)-dependent smooth muscle vasodilation, we have measured vascular endothelial and smooth muscle function in three groups of age- and sex-matched patients: 8 patients with non-insulin-dependent (Type 2) diabetes mellitus (NIDDM) with neuropathy; 7 NIDDM patients without neuropathy; and 10 non-diabetic control subjects. Laser Doppler probes were used to measure blood flow in the dorsum of the left foot. Vascular endothelial response was assessed by measuring vasodilatory responses to iontophoretic application of acetylcholine to the dorsum of the foot. Vascular smooth muscle activity was assessed by the response to iontophoresis of sodium nitroprusside (SNP)-a NO donor and direct vasodilator. The vasodilator response to acetylcholine, expressed as the ratio of peak to basal blood flow, was significantly reduced in both diabetic groups when compared to non-diabetic controls (geometric mean x/divided by anti-logged SD 9.81 x/divided by 1.65 versus patients with neuropathy 3.50 x/divided by 2.03, p < 0.005 and diabetic non-neuropathic subjects 3.49 x/divided by 1.67, p < 0.005). The difference between the two groups of diabetic patients was not significant. In contrast, the vasodilatation to nitroprusside was significantly reduced only in the diabetic neuropathic patients, significantly lower than in either the non-neuropathic diabetic controls or the non-diabetic controls (2.1 x/divided by 2.0 versus 6.42 x/divided by 1.56 and 7.02 x/divided by 2.05, p < 0.005). This indicates that neuropathy is important in abnormalities of endothelium-independent vasodilatation." @default.
- W1970782214 created "2016-06-24" @default.
- W1970782214 creator A5014670582 @default.
- W1970782214 creator A5040714094 @default.
- W1970782214 creator A5088469880 @default.
- W1970782214 date "1997-04-01" @default.
- W1970782214 modified "2023-10-10" @default.
- W1970782214 title "NO-dependent Smooth Muscle Vasodilatation is Reduced in NIDDM Patients with Peripheral Sensory Neuropathy" @default.
- W1970782214 doi "https://doi.org/10.1002/(sici)1096-9136(199704)14:4<284::aid-dia348>3.0.co;2-0" @default.
- W1970782214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9113481" @default.
- W1970782214 hasPublicationYear "1997" @default.
- W1970782214 type Work @default.
- W1970782214 sameAs 1970782214 @default.
- W1970782214 citedByCount "54" @default.
- W1970782214 countsByYear W19707822142013 @default.
- W1970782214 countsByYear W19707822142014 @default.
- W1970782214 countsByYear W19707822142015 @default.
- W1970782214 countsByYear W19707822142016 @default.
- W1970782214 countsByYear W19707822142017 @default.
- W1970782214 countsByYear W19707822142023 @default.
- W1970782214 crossrefType "journal-article" @default.
- W1970782214 hasAuthorship W1970782214A5014670582 @default.
- W1970782214 hasAuthorship W1970782214A5040714094 @default.
- W1970782214 hasAuthorship W1970782214A5088469880 @default.
- W1970782214 hasConcept C120770815 @default.
- W1970782214 hasConcept C126322002 @default.
- W1970782214 hasConcept C134018914 @default.
- W1970782214 hasConcept C2779178840 @default.
- W1970782214 hasConcept C2779610285 @default.
- W1970782214 hasConcept C2779901536 @default.
- W1970782214 hasConcept C42219234 @default.
- W1970782214 hasConcept C519581460 @default.
- W1970782214 hasConcept C555293320 @default.
- W1970782214 hasConcept C71924100 @default.
- W1970782214 hasConceptScore W1970782214C120770815 @default.
- W1970782214 hasConceptScore W1970782214C126322002 @default.
- W1970782214 hasConceptScore W1970782214C134018914 @default.
- W1970782214 hasConceptScore W1970782214C2779178840 @default.
- W1970782214 hasConceptScore W1970782214C2779610285 @default.
- W1970782214 hasConceptScore W1970782214C2779901536 @default.
- W1970782214 hasConceptScore W1970782214C42219234 @default.
- W1970782214 hasConceptScore W1970782214C519581460 @default.
- W1970782214 hasConceptScore W1970782214C555293320 @default.
- W1970782214 hasConceptScore W1970782214C71924100 @default.
- W1970782214 hasIssue "4" @default.
- W1970782214 hasLocation W19707822141 @default.
- W1970782214 hasLocation W19707822142 @default.
- W1970782214 hasOpenAccess W1970782214 @default.
- W1970782214 hasPrimaryLocation W19707822141 @default.
- W1970782214 hasRelatedWork W2017697286 @default.
- W1970782214 hasRelatedWork W2052966837 @default.
- W1970782214 hasRelatedWork W2066194374 @default.
- W1970782214 hasRelatedWork W2075050344 @default.
- W1970782214 hasRelatedWork W2082071452 @default.
- W1970782214 hasRelatedWork W2092287856 @default.
- W1970782214 hasRelatedWork W2171813959 @default.
- W1970782214 hasRelatedWork W2462451718 @default.
- W1970782214 hasRelatedWork W2552414330 @default.
- W1970782214 hasRelatedWork W2404905586 @default.
- W1970782214 hasVolume "14" @default.
- W1970782214 isParatext "false" @default.
- W1970782214 isRetracted "false" @default.
- W1970782214 magId "1970782214" @default.
- W1970782214 workType "article" @default.