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• W1970783450 abstract "Cultures of smooth muscle cells were prepared from the basilar artery of adult guinea pigs. Passaged cultures (10–30 passages) that expressed serotonin receptors were studied using [ 3 H]thymidine incorporation. When tested in quiescent medium, serotonin potently stimulated [ 3 H]thymidine incorporation (EC 50 of 31 n M) by as much as 400% at 24 h. The number of cells was not significantly increased at 24 or 48 h. At concentrations of 10 −8 –10 −5 M 5-HT, [ 3 H]thymidine uptake was reduced 40–50% by the dihydropyridine Ca 2+ channel blocker, nifedipine (1 μ M). To demonstrate a possible mechanism for the sensitivity to nifedipine, Ca 2+ currents were measured using the whole cell patch clamp technique. The cells expressed dihydropyridine-sensitive L-type Ca 2+ channels, but not other subtypes of Ca 2+ channels, as indicated by the kinetic and voltage-dependent characteristics of the current and by the stimulatory effect of Bay K 8644. The magnitude of the Ca 2+ currents was related exponentially to the membrane surface area, measured as cell capacitance. These data support the association of dihydropyridine-sensitive Ca 2+ channels with mitogenesis in vascular smooth muscle, and suggest an alternate mechanism of action for the beneficial effect of dihydropyridines in prophylaxis of cerebral vasospasm." @default.
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• W1970783450 date "1992-01-01" @default.
• W1970783450 modified "2023-09-24" @default.
• W1970783450 title "Calcium Channels and Nifedipine Inhibition of Serotonin-Induced [3H]Thymidine Incorporation in Cultured Cerebral Smooth Muscle Cells" @default.
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• W1970783450 doi "https://doi.org/10.1038/jcbfm.1992.17" @default.
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