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- W1970783483 abstract "The polyamine metabolism is pathologically changed in tumor tissues, and especially putrescine and spermidine demonstrate abnormally high values in kidney, bladder, and prostate cancer. The inductive processes which activate the biosynthetic polyamine enzymes in cancer are completely unknown. Of therapeutic interest is the fact that increased enzyme activities through irreversible inhibitors become significantly reduced, which consequently slows the tumor growth. Experimental therapy, especially in transplantable bladder and prostate cancer, displayed a 50% tumor destruction. In clinical studies using inhibitors of the polyamine biosynthesis, the dose had to be significantly reduced because of expressed toxicity. Additional investigations which tried a combination of reversible and irreversible inhibitors proved a similar antitumor activity, but less severe side effects." @default.
- W1970783483 created "2016-06-24" @default.
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- W1970783483 date "1985-01-01" @default.
- W1970783483 modified "2023-10-18" @default.
- W1970783483 title "Polyamine, Polyaminantimetaboliten und urogenitale Tumoren" @default.
- W1970783483 doi "https://doi.org/10.1159/000281092" @default.
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