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• W1970783550 abstract "Retinal cones are photoreceptors for daylight vision. For lower vertebrates, cones are known to give monophasic, hyperpolarizing responses to light flashes. For primate cones, however, they have been reported to give strongly biphasic flash responses, with an initial hyperpolarization followed by a depolarization beyond the dark level, now a textbook dogma. We have reexamined this primate-cone observation and, surprisingly, found predominantly monophasic cone responses. Correspondingly, we found that primate cones began to adapt to steady light at much lower intensities than previously reported, explainable by a larger steady response to background light for a monophasic than for a biphasic response. Similarly, we have found a monophasic cone response for several other mammalian species. Thus, a monophasic flash response may in fact be the norm for primate and other mammalian cones as for lower-vertebrate cones. This revised information is important for ultimately understanding human retinal signal processing and correlating with psychophysical data." @default.
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• W1970783550 date "2014-02-03" @default.
• W1970783550 modified "2023-10-17" @default.
• W1970783550 title "Light responses of primate and other mammalian cones" @default.
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• W1970783550 doi "https://doi.org/10.1073/pnas.1400268111" @default.
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