FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970783645> ?p ?o ?g. }

• W1970783645 endingPage "540" @default.
• W1970783645 startingPage "532" @default.
• W1970783645 abstract "Although fasting decreases insulin-mediated glucose uptake (IMGU), its effect on noninsulin-mediated glucose uptake (NIMGU) is not known. To examine this issue we studied seven obese men [mean (+/- SD) age, 36 +/- 5 yr; weight, 91 +/- 13 kg] after an overnight fast (day 0) and 3 days (day 4) and 9 days (day 10) of total fasting and six normal weight men (age, 32 +/- 4 yr; weight, 73 +/- 6 kg) after an overnight and 3 days of fasting. To study NIMGU, somatostatin (0.16 micrograms/kg.min) was infused to create severe insulin deficiency and [3H]3-glucose to measure glucose disappearance (Rd), while serum glucose was sequentially clamped at a level of about 4.7 mmol/L for 180 min and about 11 mmol/L for an additional 100 min. The results from the last 60 min of each glycemic plateau were used for analysis. Under these conditions insulin action is absent and Rd = NIMGU. Since under conditions of euglycemic insulinopenia, NIMGU into noncentral nervous system tissues is negligible, and central nervous system (CNS) glucose uptake saturates at physiological glucose concentrations, it follows that at a glucose level of about 4.7 mmol/L, NIMGU reflects CNS glucose uptake and at about 11 mmol/L, NIMGU reflect CNS plus non-CNS tissues. Thus, non-CNS NIMGU = NIMGU at 11 mmol/L - NIMGU at about 4.7 mmol/L. The obese subjects' mean weight fell to 88 +/- 5 kg on day 4 and 85 +/- 5 kg on day 10 (P less than 0.001 between all values). The mean basal serum glucose level fell from 5.3 +/- 0.1 on day 0 to 4.2 +/- 0.2 and 3.8 +/- 0.2 mmol/L on days 4 and 10, respectively (P less than 0.01 between all values). During insulinopenia plasma FFA and serum beta-hydroxybutyrate levels on day 10 were 3- and 30-fold higher than the basal prefast levels, respectively. Noninsulin-mediated glucose clearance at about 4.7 mmol/L did not change during fasting [0.0016 +/- 0.0001 (day 0) vs. 0.0016 +/- 0.0001 (day 4) and 0.0014 +/- 0.0001 L/kg.min (day 10); P = NS between all values]; at about 11 mmol/L noninsulin-mediated glucose clearance fell from 0.0016 +/- 0.0001 on day 0 to 0.0001 +/- 0.0001 dL/kg.min on day 10 (P less than 0.001). Results in the lean group were similar to those in the obese group after a 3-day fast.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W1970783645 created "2016-06-24" @default.
• W1970783645 creator A5036743289 @default.
• W1970783645 creator A5052545633 @default.
• W1970783645 creator A5052697398 @default.
• W1970783645 creator A5061381663 @default.
• W1970783645 date "1988-09-01" @default.
• W1970783645 modified "2023-09-23" @default.
• W1970783645 title "Fasting Decreases Rates of Noninsulin-Mediated Glucose Uptake in Man*" @default.
• W1970783645 cites W1951442280 @default.
• W1970783645 cites W1969572070 @default.
• W1970783645 cites W1974540301 @default.
• W1970783645 cites W1979491933 @default.
• W1970783645 cites W1993480864 @default.
• W1970783645 cites W2003781513 @default.
• W1970783645 cites W2014306439 @default.
• W1970783645 cites W2040057688 @default.
• W1970783645 cites W2051976607 @default.
• W1970783645 cites W2053607970 @default.
• W1970783645 cites W2055909792 @default.
• W1970783645 cites W2060593308 @default.
• W1970783645 cites W2065544193 @default.
• W1970783645 cites W2093484764 @default.
• W1970783645 cites W2098578065 @default.
• W1970783645 cites W2104938317 @default.
• W1970783645 cites W2113413704 @default.
• W1970783645 cites W2113637996 @default.
• W1970783645 cites W2121016515 @default.
• W1970783645 cites W2124070488 @default.
• W1970783645 cites W2124232607 @default.
• W1970783645 cites W2130200187 @default.
• W1970783645 cites W2131984640 @default.
• W1970783645 cites W2132411825 @default.
• W1970783645 cites W2143557124 @default.
• W1970783645 cites W2160978530 @default.
• W1970783645 cites W2161992213 @default.
• W1970783645 cites W2164519184 @default.
• W1970783645 cites W2164884154 @default.
• W1970783645 cites W2169401893 @default.
• W1970783645 cites W2289466277 @default.
• W1970783645 cites W2462738922 @default.
• W1970783645 cites W57499052 @default.
• W1970783645 cites W2072208752 @default.
• W1970783645 doi "https://doi.org/10.1210/jcem-67-3-532" @default.
• W1970783645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3045143" @default.
• W1970783645 hasPublicationYear "1988" @default.
• W1970783645 type Work @default.
• W1970783645 sameAs 1970783645 @default.
• W1970783645 citedByCount "15" @default.
• W1970783645 countsByYear W19707836452012 @default.
• W1970783645 countsByYear W19707836452016 @default.
• W1970783645 countsByYear W19707836452022 @default.
• W1970783645 crossrefType "journal-article" @default.
• W1970783645 hasAuthorship W1970783645A5036743289 @default.
• W1970783645 hasAuthorship W1970783645A5052545633 @default.
• W1970783645 hasAuthorship W1970783645A5052697398 @default.
• W1970783645 hasAuthorship W1970783645A5061381663 @default.
• W1970783645 hasConcept C126322002 @default.
• W1970783645 hasConcept C134018914 @default.
• W1970783645 hasConcept C17093226 @default.
• W1970783645 hasConcept C185592680 @default.
• W1970783645 hasConcept C2776297358 @default.
• W1970783645 hasConcept C2777866211 @default.
• W1970783645 hasConcept C2779306644 @default.
• W1970783645 hasConcept C2780473172 @default.
• W1970783645 hasConcept C2993808720 @default.
• W1970783645 hasConcept C529278444 @default.
• W1970783645 hasConcept C71924100 @default.
• W1970783645 hasConceptScore W1970783645C126322002 @default.
• W1970783645 hasConceptScore W1970783645C134018914 @default.
• W1970783645 hasConceptScore W1970783645C17093226 @default.
• W1970783645 hasConceptScore W1970783645C185592680 @default.
• W1970783645 hasConceptScore W1970783645C2776297358 @default.
• W1970783645 hasConceptScore W1970783645C2777866211 @default.
• W1970783645 hasConceptScore W1970783645C2779306644 @default.
• W1970783645 hasConceptScore W1970783645C2780473172 @default.
• W1970783645 hasConceptScore W1970783645C2993808720 @default.
• W1970783645 hasConceptScore W1970783645C529278444 @default.
• W1970783645 hasConceptScore W1970783645C71924100 @default.
• W1970783645 hasIssue "3" @default.
• W1970783645 hasLocation W19707836451 @default.
• W1970783645 hasLocation W19707836452 @default.
• W1970783645 hasOpenAccess W1970783645 @default.
• W1970783645 hasPrimaryLocation W19707836451 @default.
• W1970783645 hasRelatedWork W1983912401 @default.
• W1970783645 hasRelatedWork W2006513370 @default.
• W1970783645 hasRelatedWork W2054690921 @default.
• W1970783645 hasRelatedWork W2057002167 @default.
• W1970783645 hasRelatedWork W2080438079 @default.
• W1970783645 hasRelatedWork W2081817671 @default.
• W1970783645 hasRelatedWork W2096420073 @default.
• W1970783645 hasRelatedWork W2180861891 @default.
• W1970783645 hasRelatedWork W2295090947 @default.
• W1970783645 hasRelatedWork W2338711046 @default.
• W1970783645 hasVolume "67" @default.
• W1970783645 isParatext "false" @default.
• W1970783645 isRetracted "false" @default.
• W1970783645 magId "1970783645" @default.

• next