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• W1970784425 abstract "Maintaining relevant information for later use is a critical aspect of working memory (WM). The lateral prefrontal cortex (PFC) and posterior sensory cortical areas appear to be important in supporting maintenance. However, the relative and unique contributions of these areas remain unclear. We have designed a WM paradigm with distraction to probe the contents of maintenance representations in these regions. During delayed recognition trials of faces, selective interference was evident behaviorally with face distraction leading to significantly worse performance than with scene distraction. Event-related fMRI of the human brain showed that maintenance activity in the lateral PFC, but not in visual association cortex (VAC), was selectively disrupted by face distraction. Additionally, the functional connectivity between the lateral PFC and the VAC was perturbed during these trials. We propose a hierarchical and distributed model of active maintenance in which the lateral PFC codes for abstracted mnemonic information, while sensory areas represent specific features of the memoranda. Furthermore, persistent coactivation between the PFC and sensory areas may be a mechanism by which information is actively maintained." @default.
• W1970784425 created "2016-06-24" @default.
• W1970784425 creator A5037953943 @default.
• W1970784425 creator A5046805836 @default.
• W1970784425 creator A5075867931 @default.
• W1970784425 date "2006-02-01" @default.
• W1970784425 modified "2023-10-07" @default.
• W1970784425 title "Differential effects of distraction during working memory on delay-period activity in the prefrontal cortex and the visual association cortex" @default.
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• W1970784425 doi "https://doi.org/10.1016/j.neuroimage.2005.08.024" @default.
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• W1970784425 hasPublicationYear "2006" @default.
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