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• W1970785780 abstract "The enantioselective binding of [Fe(4,7-dmp)(3)](2+) (dmp: 4,7-dimethyl-1,10-phenantroline) and [Fe(3,4,7,8-tmp)(3)](2+) (tmp: 3,4,7,8-tetramethyl-1,10-phenanthroline) to calf-thymus DNA (ct-DNA) has been systematically studied by monitoring the circular dichroism (CD) spectral profile of the iron(II) complexes in the absence and presence of ct-DNA. The effect of salt concentration and temperature on the degree of enantioselectivity of the ct-DNA binding of the iron(II) complexes, i.e. the molar ratio of Delta- to Lambda-enantiomer in the solution or vice versa has been rigorously evaluated. It is noticeable that Delta-[Fe(4,7-dmp)(3)](2+) and Lambda-[Fe(3,4,7,8-tmp)(3)](2+) are preferentially bound to ct-DNA as reflected in their opposite CD spectral profiles. The preferential binding of the Lambda-enantiomer of [Fe(3,4,7,8-tmp)(3)](2+) to ct-DNA compared to that of the Delta-enantiomer is associated with the bulkiness of the ancillary ligands due to substitution of four hydrogen atoms in 1,10-phenanthroline for four methyl groups. The determination of enantiomeric inversion constant (K(inv)) at various salt concentrations has revealed that the degree of enantioselectivity is salt concentration dependent, indicating that electrostatic interaction is involved in the enantioselective binding of the iron(II) complexes to ct-DNA. Although [Fe(4,7-dmp)(3)](2+) and [Fe(3,4,7,8-tmp)(3)](2+) exhibit an opposite pattern in the CD spectra, the degree of their enantioselectivity (K(inv)) is not different from each other significantly. A thermodynamic study on the enantioselective binding of [Fe(4,7-dmp)(3)](2+) to ct-DNA using the van't Hoff plot of In K(inv) versus 1/T has demonstrated that the enthalpy change (Delta H degrees ) in the inversion process from the Lambda- to Delta-enantiomer of [Fe(4,7-dmp)(3)](2+) ct-DNA is positive, indicating that the process is endothermic and thus entropically driven." @default.
• W1970785780 created "2016-06-24" @default.
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• W1970785780 date "2008-08-01" @default.
• W1970785780 modified "2023-10-16" @default.
• W1970785780 title "Enantioselective DNA binding of iron(II) complexes of methyl-substituted phenanthroline" @default.
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• W1970785780 doi "https://doi.org/10.1016/j.jinorgbio.2008.03.003" @default.
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