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• W1970786563 abstract "Atmospheric microsized particles producing reactive oxygen species can pose a serious health risk for city residents. We studied the responses of organisms to microparticles in 255 healthy volunteers living in areas with different levels of microparticle air pollution. We analyzed the distribution of microparticles in snow samples by size and content. ELISA and flow cytometry methods were employed to determine the parameters of the thiol-disulfide metabolism, peroxidation and antioxidant, genotoxicity, and energy state of the leukocytes. We found that, in the park areas, microparticles with a size of 800 μ m or more were predominant (96%), while in the industrial areas, they tended to be less than 50 μ m (93%), including size 200–300 nm (7%). In the industrial areas, we determined the oxidative modification of proteins (21% compared to the park areas,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.05</mml:mn></mml:math>) and DNA (12%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.05</mml:mn></mml:math>), as well as changes in leukocytes’ energy potential (53%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.05</mml:mn></mml:math>). An increase in total antioxidant activity (82%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.01</mml:mn></mml:math>) and thiol-disulfide system response (thioredoxin increasing by 33%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.01</mml:mn></mml:math>; glutathione, 30%,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>≤</mml:mo><mml:mn>0.01</mml:mn></mml:math>with stable reductases levels) maintains a balance of peroxidation-antioxidant processes, protecting cellular and subcellular structures from significant oxidative damage." @default.
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• W1970786563 date "2015-01-01" @default.
• W1970786563 modified "2023-10-16" @default.
• W1970786563 title "Impact of Atmospheric Microparticles on the Development of Oxidative Stress in Healthy City/Industrial Seaport Residents" @default.
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• W1970786563 doi "https://doi.org/10.1155/2015/412173" @default.
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